scholarly journals Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

2009 ◽  
Vol 26 (11) ◽  
pp. 2486-2494 ◽  
Author(s):  
Fancy C. Thomas ◽  
Kunal Taskar ◽  
Vinay Rudraraju ◽  
Satyanarayana Goda ◽  
Helen R. Thorsheim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but notHER2/neu-positive breast cancer

Cancer ◽  
2010 ◽  
Vol 116 (2) ◽  
pp. 302-308 ◽  
Author(s):  
Kan Yonemori ◽  
Koji Tsuta ◽  
Makiko Ono ◽  
Chikako Shimizu ◽  
Akihiro Hirakawa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Blood Brain Barrier ◽  
Triple Negative ◽  
Brain Barrier ◽  
Blood Brain ◽  
Basal Type ◽  
Positive Breast Cancer

Existence of blood brain barrier in brain metastases with breast cancer

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 13513-13513
Author(s):  
M. Ono ◽  
K. Tsuta ◽  
K. Yonemori ◽  
C. Shimizu ◽  
S. Shibui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer

ACS Nano ◽  
2014 ◽  
Vol 8 (10) ◽  
pp. 9925-9940 ◽  
Author(s):  
Jason Li ◽  
Ping Cai ◽  
Alireza Shalviri ◽  
Jeffrey T. Henderson ◽  
Chunsheng He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Imaging Agents ◽  
Blood Brain

scholarly journals Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis

2020 ◽  
Vol 26 (13) ◽  
pp. 1417-1427 ◽  
Author(s):  
Carolin J. Curtaz ◽  
Constanze Schmitt ◽  
Kinga G. Blecharz-Lang ◽  
Norbert Roewer ◽  
Achim Wöckel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Blood Brain Barrier ◽  
Molecular Mechanisms ◽  
Cancer Metastasis ◽  
Brain Barrier ◽  
Target Cells ◽  
Breast Cancer Patients ◽  
Blood Brain ◽  
The Brain

Brain metastases are a major cause of death in breast cancer patients. A key event in the metastatic progression of breast cancer in the brain is the migration of cancer cells across the blood-brain barrier (BBB). The BBB is a natural barrier with specialized functions that protect the brain from harmful substances, including antitumor drugs. Extracellular vesicles (EVs) sequestered by cells are mediators of cell-cell communication. EVs carry cellular components, including microRNAs that affect the cellular processes of target cells. Here, we summarize the knowledge about microRNAs known to play a significant role in breast cancer and/or in the BBB function. In addition, we describe previously established in vitro BBB models, which are a useful tool for studying molecular mechanisms involved in the formation of brain metastases.

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