Crystallization of Organic Glasses: Effects of Polymer Additives on Bulk and Surface Crystal Growth in Amorphous Nifedipine

2011 ◽  
Vol 28 (10) ◽  
pp. 2458-2466 ◽  
Author(s):  
Ting Cai ◽  
Lei Zhu ◽  
Lian Yu
Keyword(s):  
Crystal Growth ◽  
Polymer Additives ◽  
Organic Glasses ◽  
Surface Crystal

Crystallization of Organic Glasses: How Does Liquid Flow Damage Surface Crystal Growth?

2016 ◽  
Vol 16 (5) ◽  
pp. 2931-2936 ◽  
Author(s):  
Daniele Musumeci ◽  
Mariko Hasebe ◽  
Lian Yu
Keyword(s):  
Crystal Growth ◽  
Liquid Flow ◽  
Organic Glasses ◽  
Surface Crystal

scholarly journals Fast Surface Crystal Growth on Organic Glasses Studied by High - resolution Microscopy

2013 ◽  
Vol 19 (S2) ◽  
pp. 278-279
Author(s):  
M. Hasebe ◽  
D. Musumeci ◽  
L. Yu
Keyword(s):  
Crystal Growth ◽  
High Resolution ◽  
Organic Glasses ◽  
Surface Crystal ◽  
High Resolution Microscopy

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.

scholarly journals Crystal growth of the core and rotated epitaxial shell of a heterometallic metal-organic framework revealed with atomic force microscopy

2021 ◽  
Author(s):  
Fajar Inggit Pambudi ◽  
Michael William Anderson ◽  
Martin Attfield
Keyword(s):  
Atomic Force Microscopy ◽  
Crystal Growth ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Force Microscopy ◽  
The Core ◽  
Atomic Force ◽  
Metal Organic ◽  
Surface Crystal ◽  
Organic Framework

Atomic force microscopy has been used to determine the surface crystal growth of two isostructural metal-organic frameworks, [Zn2(ndc)2(dabco)] (ndc = 1,4-naphthalene dicarboxylate, dabco = 4-diazabicyclo[2.2.2]octane) (1) and [Cu2(ndc)2(dabco)] (2) from...

scholarly journals Stability of Amorphous Pharmaceutical Solids: Crystal Growth Mechanisms and Effect of Polymer Additives

2012 ◽  
Vol 14 (3) ◽  
pp. 380-388 ◽  
Author(s):  
Ye Sun ◽  
Lei Zhu ◽  
Tian Wu ◽  
Ting Cai ◽  
Erica M. Gunn ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Polymer Additives ◽  
Growth Mechanisms ◽  
Pharmaceutical Solids

Bubble-induced fast crystal growth of indomethacin polymorphs in a supercooled liquid

2021 ◽  
Vol 54 (5) ◽  
Author(s):  
Qin Shi ◽  
Fang Li ◽  
Jia Xu ◽  
Lingling Wu ◽  
Junbo Xin ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Physical Stability ◽  
Pharmaceutical Formulations ◽  
Supercooled Liquid ◽  
Pharmaceutical Solids ◽  
Liquid Bubble ◽  
Different Temperatures ◽  
Surface Crystal

Physical stability is one of the main challenges when developing robust amorphous pharmaceutical formulations. This article reports fast crystal growth behaviors of the γ and α forms of indomethacin (IMC) initiated by bubbles in the interior of a supercooled liquid. Bubble-induced crystal growth of γ-IMC exhibits approximately the same kinetics as its surface crystal growth, supporting the view that bubble-induced crystal growth is a surface-facilitated process. In contrast, the rates of bubble-induced crystal growth of α-IMC are much faster than those of its surface crystal growth. These results indicate that the bubble-induced crystal growth not only depends on the interface created by the bubble but also strongly correlates with the true cavitation of the bubble. Moreover, bubble-induced fast crystal growth of γ- and α-IMC can be terminated at different temperatures by cooling. These outcomes are meaningful for the in-depth understanding of physical stability and pre-formulation study of amorphous pharmaceutical solids showing surface-facilitated crystal growth.

A Simple Method for Estimating the Extent of Surface Crystal Development on Colored Cheddar Cheese

1986 ◽  
Vol 49 (6) ◽  
pp. 421-422 ◽  
Author(s):  
STEPHEN T. DYBING ◽  
STEVEN A. BRUDVIG ◽  
JAMES A. WIEGAND ◽  
EMIL A. HUANG
Keyword(s):  
Crystal Growth ◽  
Shelf Life ◽  
Environmental Conditions ◽  
Cheddar Cheese ◽  
Simple Method ◽  
Flat Surfaces ◽  
White Cheese ◽  
Shelf Life Studies ◽  
Non Destructive ◽  
Surface Crystal

A simple, non-destructive method for estimating the extent of crystal development as white specks on the surface of colored Cheddar cheese is described. This method involves photocopying the surface of the cheese with a photocopier set at an exposure calibrated to clearly show the crystals. The photocopies of the cheese surface are then compared to a series of photocopies showing designated increases in crystal growth. Crystal development was rated as follows: 0 = no crystals, 1= light, 2 = medium, 3 = heavy, and 4 = very heavy to encrusted crystal development. The method does not disrupt or destroy the environmental conditions existing in the cheese package, allowing extended shelf life studies to be done on the same piece of cheese. However, the photocopy technique may not work as well with white cheese or cheeses without flat surfaces.

Fast Crystal Growth from Organic Glasses: Comparison of o-Terphenyl with its Structural Analogs

2014 ◽  
Vol 118 (28) ◽  
pp. 8203-8209 ◽  
Author(s):  
C. Travis Powell ◽  
Keewook Paeng ◽  
Zhen Chen ◽  
Ranko Richert ◽  
Lian Yu ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Organic Glasses
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