The impact of metabolic syndrome on mental health-related quality of life and depressive symptoms

e18232 Background: Few studies have evaluated the impacts of depressive symptoms and mental health on patients diagnosed with multiple myeloma (MM). The aim of this study was to examine associations between depressive symptoms and poor mental health-related quality of life in relation to survival in a cohort of older MM patients. Methods: We conducted an analysis using a prospective cohort from the Surveillance, Epidemiology, and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) of patients aged 65 years and older diagnosed with first primary MM between 1998 and 2014. Subjects were required to have completed at least 1 pre-diagnosis survey and depressive symptoms were determined based on positive responses to at least 1 of 3 depression screening questions. Veterans-RAND-12 mental component scores (MCS) were also analyzed to evaluate mental health-related quality of life. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between pre-diagnosis depressive symptoms and risks of all-cause and cancer-specific mortality. Secondary analyses examined mortality risks in relation to pre-diagnosis MCS. Results: Of 522 multiple myeloma patients, the mean (SD) age at diagnosis was 76.9 (6.1) years and 158 (30%) self-reported positive depressive symptoms. Patients with depressive symptoms had a higher number of comorbid conditions and nearly all (84%) scored below the median MCS. Pre-diagnosis depressive symptoms were not associated with all-cause (HR 1.01, 95% CI: 0.79-1.29) or cancer-specific mortality (HR 0.94, 95% CI: 0.69-1.28). Myeloma patients scoring in the second MCS tertile (versus the highest tertile) had a modestly increased risk of all-cause (HR 1.19, 95% CI 0.91-1.55) and cancer-specific mortality (HR 1.17, 95% CI 0.86-1.60), but these estimates were not statistically significant. Conclusions: Pre-diagnosis depressive symptoms and lower mental health-related quality of life are not associated with survival for MM. Nevertheless, the considerably high prevalence of depressive symptoms and poor mental health status among older patients with multiple myeloma deserves clinical attention.

Download Full-text

Health-Related Quality of Life and Mental Health in Primary Aldosteronism: A Systematic Review

Hormone and Metabolic Research ◽

10.1055/s-0043-121706 ◽

2017 ◽

Vol 49 (12) ◽

pp. 943-950 ◽

Cited By ~ 8

Author(s):

Marieke Velema ◽

Aline de Nooijer ◽

Vivian Burgers ◽

Ad. Hermus ◽

Henri Timmers ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

General Population ◽

Primary Aldosteronism ◽

Health Related Quality ◽

Inclusion Criteria ◽

Related Quality ◽

Health Related ◽

The Impact

AbstractThe aim of this review was to determine the impact of primary aldosteronism on health-related quality of life (HRQoL) and mental health. We performed a systematic literature search up to July 2017 in six electronic databases. First, we screened the articles derived from this search based on title and abstract. Second, the selected studies were systematically reviewed and checked for our predefined inclusion criteria. The search yielded 753 articles, of which 15 studies met our inclusion criteria. Untreated patients with primary aldosteronism showed an impaired physical and mental HRQoL as compared to the general population. Multiple domains of HRQoL were affected. This applied to patients with both an aldosterone-producing adenoma and bilateral adrenal hyperplasia. Adrenalectomy improves HRQoL. Conflicting results have been reported on the extent of this improvement, the improvement after initiation of medical treatment, and whether there is a difference in HRQoL after both treatments. Similarly, psychopathological symptoms of anxiety, demoralization, stress, depression and nervousness were more frequently reported in untreated patients with primary aldosteronism than in the general population and patients with hypertension. Also an impaired sleep quality has been reported. Improvement of these symptoms was observed after treatment with both adrenalectomy and mineralocorticoid receptor antagonists. This review shows that HRQoL is impaired and psychopathology is more frequently reported in patients with primary aldosteronism. This seems to be at least partly reversible after treatment but the extent of improvement remains unknown. To assess HRQoL in these patients more precisely a primary aldosteronism-specific HRQoL questionnaire is required.

Download Full-text

The Impact of a Previous Ankle Injury on Current Health-Related Quality of Life in College Athletes

Journal of Sport Rehabilitation ◽

10.1123/jsr.2018-0249 ◽

2020 ◽

Vol 29 (1) ◽

pp. 43-50

Author(s):

Ashley N. Marshall ◽

Alison R. Snyder Valier ◽

Aubrey Yanda ◽

Kenneth C. Lam

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Ankle Injury ◽

Health Related Quality ◽

Injury Group ◽

Related Quality ◽

Health Related ◽

Main Effects ◽

The Impact

Context: There has been an increased interest in understanding how ankle injuries impact patient outcomes; however, it is unknown how the severity of a previous ankle injury influences health-related quality of life (HRQOL). Objective: To determine the impact of a previous ankle injury on current HRQOL in college athletes. Design: Cross-sectional study. Setting: Athletic training clinics. Participants: A total of 270 participants were grouped by the severity of a previous ankle injury (severe = 62, mild = 65, and no injury = 143). Main Outcome Measures: Participants completed the Foot and Ankle Ability Measure (FAAM) and the Short Form 12 (SF-12). Methods: A 2-way analysis of variance with 2 factors (injury group and sex) was used to identify interaction and main effects for the FAAM and SF-12. Results: No interactions were identified between injury group and sex. Significant main effects were observed for injury group, where the severe injury group scored lower than athletes with mild and no injuries on the FAAM activities of daily living, FAAM Global, and SF-12 mental health subscale scores. In addition, a main effect was present for sex in the SF-12 general health, social functioning, and mental health subscales in which females reported significantly lower scores than males. Conclusions: Our findings suggest that a severe ankle injury impacts HRQOL, even after returning back to full participation. In addition, females tended to report lower scores than males for aspects of the SF-12, suggesting that sex should be considered when evaluating HRQOL postinjury. As a result, clinicians should consider asking athletes about their previous injury history, including how much time was lost due to the injury, and should mindful of returning athletes to play before they are physiologically and psychologically ready, as there could be long-term negative effects on the patients’ region-specific function as well as aspects of their HRQOL.

Download Full-text

Change in depressive symptoms and mental health-related quality of life in northeast Germany between 1997–2001 and 2008–2012

International Journal of Public Health ◽

10.1007/s00038-014-0632-0 ◽

2014 ◽

Vol 60 (1) ◽

pp. 33-39 ◽

Cited By ~ 4

Author(s):

Sebastian E. Baumeister ◽

Georg Schomerus ◽

Carsten-Oliver Schmidt ◽

Franz Möckel ◽

Neeltje van den Berg ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Depressive Symptoms ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Download Full-text

Gender differences in health-related quality of life in multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458509107016 ◽

2009 ◽

Vol 15 (11) ◽

pp. 1339-1346 ◽

Cited By ~ 34

Author(s):

Ilaria Casetta ◽

Trond Riise ◽

Monica Wamme Nortvedt ◽

Nicola Tiberio Economou ◽

Riccardo De Gennaro ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Multiple Sclerosis ◽

Physical Functioning ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

The Impact ◽

Gender Specific

Women have about twice the risk of developing multiple sclerosis (MS) compared with men, a ratio that seems to be increasing. Most studies show that female patients seem to have a more favourable outcome of the disease. We studied the gender-specific impact of MS on health-related quality of life. We surveyed the population prevalence of MS patients in Ferrara, Italy. Data were extracted from the MS registry of the study area. Health-related quality of life was assessed using the MSQOL54 questionnaire. We analysed 370 patients (105 men and 265 women). They had worse scores than the general population in all health-related quality of life dimensions, ranging from 2.5 standard deviations (SD) lower for physical functioning to less than 0.5 standard deviations for mental health. Health-related quality of life scores were inversely correlated with disability scores. The impact of disability on health-related quality of life was higher for men than women regarding physical functioning (p < 0.01), vitality (p < 0.001), social functioning (p < 0.001), emotional wellbeing (p < 0.05) and mental health (p < 0.01). For scales reflecting mental health, a marked reduction with increasing disability was seen for men, while a linear reduction in the range of Expanded Disability Status Scale score 0—5 was reported for women, followed by no clear decrease for higher scores. We conclude that MS affects health-related quality of life in all of its dimensions. The impact of disability seems to be stronger among men, in particular for scales related to mental well-being. This could indicate that interventions should to be gender specific in order to better meet patients’ needs.

Download Full-text

360 Efficacy of CBT-I and its Components on Health-Related Quality of Life Outcomes in Older Adults

SLEEP ◽

10.1093/sleep/zsab072.359 ◽

2021 ◽

Vol 44 (Supplement_2) ◽

pp. A143-A144

Author(s):

Kelly Showen ◽

Kathleen O’Hora ◽

Beatriz Hernandez ◽

Laura Lazzeroni ◽

Jamie Zeitzer ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Older Adults ◽

Health Related Quality ◽

Health Related Qol ◽

Related Quality ◽

Health Related ◽

The Impact ◽

Over Time

Abstract Introduction Insomnia affects 30–48% of older adults and impairs health-related quality of life (HRQoL). Numerous studies report Cognitive Behavioral Therapy (CBT-I) as an effective non-pharmacological treatment for insomnia symptoms, with few examining the impact of CBT-I on mental and physical aspects of HRQoL. While limited research suggests that CBT-I leads to improvements in HRQoL, the impact of the cognitive versus behavioral components of CBT-I on HRQoL is unknown. Methods 128 older adults with insomnia (mean age=69, 66% female, 19% minority) were randomized to receive cognitive therapy (CT), behavior therapy (BT), or CBT-I. The Short Form (36) Health Survey (SF-36) was collected at baseline, post-treatment and six-month follow-up. Split-plot linear mixed models with age and sex as covariates to assess within and between subject changes were used to test intervention, time, and interaction effects on the mental health and physical well-being domains of HRQoL. Significance for all effects was defined as p < 0.05. The effect size (d) was calculated by dividing the difference between means by the root-mean-squared error of the mixed effects model. Results The mental health-related QoL improved over time independent of treatment (Main effect of time: F(2, 202) = 6.51, p < 0.002). The interaction failed to reach significance (Interaction: F(4, 202) = 1.19, p = .31). Simple effects revealed significant improvements among CBT-I participants at six months (p = .02, d = .53) and CT participants at post-treatment (p = .00, d = .79) and six months (p = .03, d = .66), but not among BT participants for either time point (p = .32, d = .24; p = .16, d = .35). Treatment did not improve physical health-related QoL over time (F(2, 202) = 1.01, p = .37) nor was there a significant interaction (F(4, 202) = .46, p = .76). Conclusion These findings suggest that CBT-I, particularly the CT component, may be effective in improving mental health-related QoL outcomes for older adults with insomnia. In contrast, neither CBT-I nor its component treatments were effective in improving physical health-related QoL. Support (if any) NIMHR01MH101468-01; Mental Illness Research, Education, and Clinical Center (MIRECC) at the VAPAHCS

Download Full-text

Changes in metabolic syndrome affect the health-related quality of life of community-dwelling adults

Scientific Reports ◽

10.1038/s41598-021-99767-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yi-Hsuan Lin ◽

Hsiao-Ting Chang ◽

Yen-Han Tseng ◽

Harn-Shen Chen ◽

Shu-Chiung Chiang ◽

...

Keyword(s):

Quality Of Life ◽

Metabolic Syndrome ◽

Community Dwelling ◽

Renal Diseases ◽

Baseline Body Mass Index ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

The Impact

AbstractMetabolic syndrome (MetS) is associated with cardiovascular diseases, type 2 diabetes, chronic renal diseases, and all-cause mortality. Furthermore, MetS is associated with poor health-related quality of life (HRQOL). However, the impact of dynamic changes in MetS on changes in the HRQOL was not previously explored. This was an eight-year, prospective cohort study in which 906 middle-aged adults from Shipai, Taipei in northern Taiwan were enrolled during 2009–2010 (baseline). Of those sampled, 427 participants completed the follow-up investigation after 8 years. The HRQOL was measured using the Short Form Health Survey (SF-36). Other variables including age, sex, marital status, level of education, smoking, alcohol consumption, baseline body mass index, and changes in physical activity were adjusted. Compared with adults who never experienced MetS, adults with persistent MetS had a negative change in mental HRQOL (β − 4.20, 95% CI − 7.54 to − 0.86, p = 0.01). The negative changes of persistent MetS on the HRQOL were in the domains of vitality and mental health (β − 4.42, 95% CI − 8.10 to − 0.73 and β − 3.47, 95% CI − 6.90 to − 0.04, respectively). Women and overweight adults were vulnerable to the detrimental effects of persistent MetS. For better HRQOL, more resources should be devoted to reversing MetS in public health.

Download Full-text