scholarly journals Parallel multi-objective optimization approaches for protein encoding

Author(s):  
Belen Gonzalez-Sanchez ◽  
Miguel A. Vega-Rodríguez ◽  
Sergio Santander-Jiménez

AbstractOne of the main challenges in synthetic biology lies in maximizing the expression levels of a protein by encoding it with multiple copies of the same gene. This task is often conducted under conflicting evaluation criteria, which motivates the formulation of protein encoding as a multi-objective optimization problem. Recent research reported significant results when adapting the artificial bee colony algorithm to address this problem. However, the length of proteins and the number of copies have a noticeable impact in the computational costs required to attain satisfying solutions. This work is aimed at proposing parallel bioinspired designs to tackle protein encoding in multiprocessor systems, considering different thread orchestration schemes to accelerate the optimization process while preserving the quality of results. Comparisons of solution quality with other approaches under three multi-objective quality metrics show that the proposed parallel method reaches significant quality in the encoded proteins. In addition, experimentation on six real-world proteins gives account of the benefits of applying asynchronous shared-memory schemes, attaining efficiencies of 92.11% in the most difficult stages of the algorithm and mean speedups of 33.28x on a 64-core server-grade system.

2020 ◽  
Vol 40 (4) ◽  
pp. 360-371
Author(s):  
Yanli Cao ◽  
Xiying Fan ◽  
Yonghuan Guo ◽  
Sai Li ◽  
Haiyue Huang

AbstractThe qualities of injection-molded parts are affected by process parameters. Warpage and volume shrinkage are two typical defects. Moreover, insufficient or excessively large clamping force also affects the quality of parts and the cost of the process. An experiment based on the orthogonal design was conducted to minimize the above defects. Moldflow software was used to simulate the injection process of each experiment. The entropy weight was used to determine the weight of each index, the comprehensive evaluation value was calculated, and multi-objective optimization was transformed into single-objective optimization. A regression model was established by the random forest (RF) algorithm. To further illustrate the reliability and accuracy of the model, back-propagation neural network and kriging models were taken as comparative algorithms. The results showed that the error of RF was the smallest and its performance was the best. Finally, genetic algorithm was used to search for the minimum of the regression model established by RF. The optimal parameters were found to improve the quality of plastic parts and reduce the energy consumption. The plastic parts manufactured by the optimal process parameters showed good quality and met the requirements of production.


2021 ◽  
pp. 1-21
Author(s):  
Xin Li ◽  
Xiaoli Li ◽  
Kang Wang

The key characteristic of multi-objective evolutionary algorithm is that it can find a good approximate multi-objective optimal solution set when solving multi-objective optimization problems(MOPs). However, most multi-objective evolutionary algorithms perform well on regular multi-objective optimization problems, but their performance on irregular fronts deteriorates. In order to remedy this issue, this paper studies the existing algorithms and proposes a multi-objective evolutionary based on niche selection to deal with irregular Pareto fronts. In this paper, the crowding degree is calculated by the niche method in the process of selecting parents when the non-dominated solutions converge to the first front, which improves the the quality of offspring solutions and which is beneficial to local search. In addition, niche selection is adopted into the process of environmental selection through considering the number and the location of the individuals in its niche radius, which improve the diversity of population. Finally, experimental results on 23 benchmark problems including MaF and IMOP show that the proposed algorithm exhibits better performance than the compared MOEAs.


2020 ◽  
Author(s):  
Tomohiro Harada ◽  
Misaki Kaidan ◽  
Ruck Thawonmas

Abstract This paper investigates the integration of a surrogate-assisted multi-objective evolutionary algorithm (MOEA) and a parallel computation scheme to reduce the computing time until obtaining the optimal solutions in evolutionary algorithms (EAs). A surrogate-assisted MOEA solves multi-objective optimization problems while estimating the evaluation of solutions with a surrogate function. A surrogate function is produced by a machine learning model. This paper uses an extreme learning surrogate-assisted MOEA/D (ELMOEA/D), which utilizes one of the well-known MOEA algorithms, MOEA/D, and a machine learning technique, extreme learning machine (ELM). A parallelization of MOEA, on the other hand, evaluates solutions in parallel on multiple computing nodes to accelerate the optimization process. We consider a synchronous and an asynchronous parallel MOEA as a master-slave parallelization scheme for ELMOEA/D. We carry out an experiment with multi-objective optimization problems to compare the synchronous parallel ELMOEA/D with the asynchronous parallel ELMOEA/D. In the experiment, we simulate two settings of the evaluation time of solutions. One determines the evaluation time of solutions by the normal distribution with different variances. On the other hand, another evaluation time correlates to the objective function value. We compare the quality of solutions obtained by the parallel ELMOEA/D variants within a particular computing time. The experimental results show that the parallelization of ELMOEA/D significantly reduces the computational time. In addition, the integration of ELMOEA/D with the asynchronous parallelization scheme obtains higher quality of solutions quicker than the synchronous parallel ELMOEA/D.


2019 ◽  
Vol 24 (10) ◽  
pp. 7685-7714 ◽  
Author(s):  
Makram Soui ◽  
Mabrouka Chouchane ◽  
Mohamed Wiem Mkaouer ◽  
Marouane Kessentini ◽  
Khaled Ghedira

2017 ◽  
Vol 26 (05) ◽  
pp. 1760016 ◽  
Author(s):  
Shubhashis Kumar Shil ◽  
Samira Sadaoui

This study introduces an advanced Combinatorial Reverse Auction (CRA), multi-units, multiattributes and multi-objective, which is subject to buyer and seller trading constraints. Conflicting objectives may occur since the buyer can maximize some attributes and minimize some others. To address the Winner Determination (WD) problem for this type of CRAs, we propose an optimization approach based on genetic algorithms that we integrate with our variants of diversity and elitism strategies to improve the solution quality. Moreover, by maximizing the buyer’s revenue, our approach is able to return the best solution for our complex WD problem. We conduct a case study as well as simulated testing to illustrate the importance of the diversity and elitism schemes. We also validate the proposed WD method through simulated experiments by generating large instances of our CRA problem. The experimental results demonstrate on one hand the performance of our WD method in terms of several quality measures, like solution quality, run-time complexity and trade-off between convergence and diversity, and on the other hand, it’s significant superiority to well-known heuristic and exact WD techniques that have been implemented for much simpler CRAs.


2018 ◽  
Vol 46 (2) ◽  
pp. 85-97 ◽  
Author(s):  
Hongxing Zhao ◽  
Ruichun He ◽  
Jiangsheng Su

Vehicle delay and stops at intersections are considered targets for optimizing signal timing for an isolated intersection to overcome the limitations of the linear combination and single objective optimization method. A multi-objective optimization model of a fixed-time signal control parameter of unsaturated intersections is proposed under the constraint of the saturation level of approach and signal time range. The signal cycle and green time length of each phase were considered decision variables, and a non-dominated sorting artificial bee colony (ABC) algorithm was used to solve the multi-objective optimization model. A typical intersection in Lanzhou City was used for the case study. Experimental results showed that a single-objective optimization method degrades other objectives when the optimized objective reaches an optimal value. Moreover, a reasonable balance of vehicle delay and stops must be achieved to flexibly adjust the signal cycle in a reasonable range. The convergence is better in the non-dominated sorting ABC algorithm than in non-dominated sorting genetic algorithm II, Webster timing, and weighted combination methods. The proposed algorithm can solve the Pareto front of a multi-objective problem, thereby improving the vehicle delay and stops simultaneously.


2020 ◽  
Vol 41 (1) ◽  
pp. 34-49
Author(s):  
Sandip B. Gunjal ◽  
Padmakar J. Pawar

Magnetic abrasive finishing is a super finishing process in which the magnetic field is applied in the finishing area and the material is removed from the workpiece by magnetic abrasive particles in the form of microchips. The performance of this process is decided by its two important quality characteristics, material removal rate and surface roughness. Significant process variables affecting these two characteristics are rotational speed of tool, working gap, weight of abrasive, and feed rate. However, material removal rate and surface roughness being conflicting in nature, a compromise has to be made between these two objective to improve the overall performance of the process. Hence, a multi-objective optimization using an artificial bee colony algorithm coupled with response surface methodology for mathematical modeling is attempted in this work. The set of Pareto-optimal solutions obtained by multi-objective optimization offers a ready reference to process planners to decide appropriate process parameters for a particular scenario.


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