Diagnostic efficacy and influence factors of urinary protein/creatinine ratio replacing 24-h urine protein as an evaluator of proteinuria in children

2021 ◽  
Author(s):  
Panpan Zhai ◽  
Yanjie Huang ◽  
Shangsai Yue ◽  
Xiaoqing Yang ◽  
Jinghui Luo ◽  
...  
Keyword(s):  
Influence Factors ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Diagnostic Efficacy

scholarly journals Comparative study of 24-hour urinary protein and spot urine protein creatinine ratio in pre-eclamptic women

2021 ◽  
Vol 10 (7) ◽  
pp. 2734
Author(s):  
Rupakala B. M. ◽  
Akshata S. Hiremath
Keyword(s):  
Predictive Value ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Spearman Correlation ◽  
Urine Protein ◽  
Spot Urine ◽  
Medical College ◽  
Urine Protein Excretion ◽  
Protein Excretion ◽  
Urine Specimens

Background: The aim of the study was to evaluate the ability of the random urine P/C ratio to predict significant proteinuria, as well as to introduce a diagnostic test for pre-eclampsia which will avoid the inconvenience and time consumption of 24-hour urine protein collection. The objective of this study was to compare spot urine protein- creatinine ratio with 24-hour urine protein for estimation of proteinuria in pre-eclampsia.Methods: A total of 50 pregnant women with pre-eclampsia were prospectively studied for proteinuria in Rajarajeswari medical college and Hospital Bangalore for a period of 9 months from September 2018 to May 2019. Spot urine specimens for measuring P/C ratio were obtained immediately before 24-hour urine collection. The correlation between the spot urine P/C ratio and urinary protein excretion in the 24-hour collections was examined using the Spearman correlation test.Results: PCR at a cut off value 0.15 g/mmol had sensitivity and specificity of 96.6% and 55% respectively. In prediction of proteinuria of 300 mg/24 hr positive predictive value and negative predictive value 76.3% and 91.6% respectively.Conclusions: We found that there was a strong correlation between 24-hour urine protein excretion and spot urine protein creatinine ratio in pre-eclamptic women. Spot PCR can be used as a reasonable alternative to 24-hour urine protein test which is a cumbersome.

scholarly journals Assessment of Proteinuria in Nephrotic Syndrome in Children by Using Spot Urinary Protein/Creatinine Ratio

2018 ◽  
Vol 42 (3) ◽  
pp. 108-111
Author(s):  
Delowar Hossain ◽  
Zahiruddin ◽  
Monimul Hoque
Keyword(s):  
Nephrotic Syndrome ◽  
Total Protein ◽  
Mean Value ◽  
Urinary Protein ◽  
Urine Collection ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Spot Urine ◽  
Protein Excretion ◽  
The Mean

Background: Quantification of proteinuria is usually predicted upon 24-hour urine collection. Multiple factors influence urine collection and the rate of protein and creatinine excretion. A spot urine protein-creatinine (P-C) ratio has been shown over the years to be a reliable alternative to the 24-hour collection for detection and follow up of proteinuria. The objective of the study was to evaluate the accuracy of urine protein creatinine ratio (UP/UC) in a spot sample for quantitative measurement of proteinuria in comparison with 24 hours urinary protein excretion in children of nephrotic syndrome having normal Glomerular Filtration Rate (GFR). Methodology: This was a prospective study conducted in the department of paediatrics, Sir Salimullah Medical College & Mitford Hospital Dhaka over a period of six months from January 2003. Fifty cases of Nephrotic syndrome were included who were on initial attack and relapse cases noted down into the proforma with respect to history, examination and investigation. All the patients were advised regarding 24 hours urine collection. They were asked to give a 24 hours urine sample starting at 9.00 am for total protein excretion rate. A spot urine sample was obtained and urine protein/creatinine ratio was calculated. The data was analyzed by linear regression and by calculating the correlation coefficient between urinary protein/ creatinine ratio and 24-hour urinary protein. Results: Sample size was fifty. Urine total protein in a timed 24-hour sample of nephrotic syndrome patients was in the range of 300-3150mg/m2/hour with the mean value of 1725 mg/m2/hour. While as U(Pr/Cr) ratio ranged from 3.1-27.5 with the mean value of 15.2. A significant correlation was found between timed 24-hour urinary protein and UP/UC ratio (r=0.622, p=<.001.) Conclusions: Spot urine protein-creatinine ratio is highly reliable and rapid test for quantification of proteinuria in children with nephrotic syndrome. Bangladesh J Child Health 2018; VOL 42 (3) :108-111

scholarly journals A study of spot urine protein: creatinine ratio as an alternative to 24 hours proteinuria for the diagnosis of pre-eclampsia

2019 ◽  
Vol 9 (1) ◽  
pp. 140
Author(s):  
Ruma Sarkar ◽  
Shilpi Rawat ◽  
Neela Rai Sharma ◽  
Harish Chandra Tiwari
Keyword(s):  
Blood Pressure ◽  
Urine Sample ◽  
Blood Pressure Level ◽  
Protein Detection ◽  
Pressure Level ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Systolic Blood Pressure Level ◽  
Spot Urine

Background: Preeclampsia is defined as systolic blood pressure level of 140 mmHg or higher or a diastolic blood pressure level of 90 mmHg or higher that occurs after 20 weeks of gestation with proteinuria. Objective of this study was to study the role of spot urine protein: creatinine ratio as an alternative to 24 hours proteinuria for the diagnosis of pre-eclampsiaMethods: This is a prospective observational study conducted in the department of obstetrics and gynaecology, BRD Medical College Gorakhpur, since October 2016 to September 2017 included 120 pregnant women with hypertension of gestational age more than 20 weeks. Ramdom urine sample of all the patient was taken before 12 noon after first voiding. For 24 hours urine sample patient was asked to collect all her urine she voids during 24 hours. The creatinine was estimated by the alkaline picrate method (Jaffe's Reaction) modified by the Bonsnes and Taussky, 1945. Creatinine in a protein free solution reacts with the alkaline picrate and produces red colour complex which is measured colorimeterically. Urinary protein was estimated in all the subjects by the Turbidimetric method. Urinary protein was precipitated by 3% sulphosalicylic acid and turbidity so produced was measured colorimetrically.Results: Protein: creatinine ratio in a random urine sample is better than random urine protein detection by dipstick method in cases of emergency when there is no time for detection of 24 hours urine protein.Conclusions: If cut-off level for urine protein: creatinine ratio in random urine sample is taken as 0.25 or more then sensitivity and specificity become same as 24 hours urine protein.                                 

scholarly journals Comparison of urine protein creatinine ratio and 24 hours urine protein in detecting preeclampsia

2019 ◽  
Vol 14 (2) ◽  
pp. 49-53
Author(s):  
Nesuma Sedhain ◽  
Jageshwor Gautam ◽  
Gehanath Baral
Keyword(s):  
Area Under The Curve ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
Protein Determination ◽  
Cross Sectional ◽  
Spot Urine ◽  
Urine Protein Excretion ◽  
Protein Excretion

Aim: To assess the diagnostic accuracy of spot urine protein-creatinine ratio for detection of proteinuria in Preeclampsia. Methods: Cross Sectional Descriptive Study was conducted in a total of 38 pregnant women in Paropakar Maternity and Women’s Hospital in study period of 3 month. The correlation between protein- creatinine ratio in spot urine samples and urinary protein excretion in 24-hour collections were analyzed. Results: Comparison of 24 hours urinary protein and protein- creatinine ratio in women with preeclampsia shows a significant correlation (r=0.911, p<0.0001). The cut-off protein-creatinine ratios which gave maximum area under the curve for 300mg protein for 24hrs was 0.27 (sensitivity: 94.6%, specificity: 100%, PPV: 100%, NPV: 33.3%); 2000 mg urine protein excretion was 2.1 (sensitivity and specificity of 100%); 3000mg protein excreted for 24hours was 3.0 (sensitivity: 83.3%, specificity: 92.3%, PPV: 83.3%, NPV: 93.3%. Area under the ROC for 24hours urine total protein of >300mg, >2000mg and >3000mg/day were 0.946 (95%CI 0.873-1.019), 1 (95% CI 1.00-1.00) and 0.957 (95%CI 0.897- 1.016) respectively. Conclusions: Spot urine protein-creatinine ratio is as accurate as to 24 hours urine protein determination of proteinuria in Preeclampsia.

scholarly journals Estimation of Protein / Creatinine Ration in Pre Eclampsia with Single Voided Urine Sample Compare with 24 Hours Urine Protein

2021 ◽  
Vol 11 (3-S) ◽  
pp. 35-47
Author(s):  
Tarannum Khatun ◽  
Kritanjali Ghimire ◽  
Shahid Alam
Keyword(s):  
Characteristic Curve ◽  
College Teaching ◽  
Receiver Operator Characteristic Curve ◽  
Urinary Protein ◽  
Ratio Test ◽  
Creatinine Ratio ◽  
Pregnant Mother ◽  
Validity And Reliability ◽  
Urine Protein ◽  
Cross Sectional

Background: Preeclampsia is characterized by hypertension and proteinuria with the onset after 20 weeks of gestation. Globally 14.5% of maternal death is due to preeclampsia with fetal complications. National Record of Family Health Division Nepal shows prevalence rate of preeclampsia as 8.5%. The gold standard 24 hours urine protein evaluation test is time consuming for the diagnosis of preeclampsia and can increase complications to mother and fetus. Instant diagnosis and prompt management is needed. Objective of this study was to determine the accuracy of urinary protein/creatinine (P/C) ratio test and correlate random urinary (P/C) ratio with twenty-four hours urinary protein in detecting preeclampsia. Methods: A cross sectional study was carried out conveniently selecting 130 samples of preeclampsia from Obstetrics and Gynaecology Department of National Medical College Teaching Hospital, Birgunj, Nepal. Out of 130 samples all met the inclusion criteria. Both twenty-four hours urine protein and P/C ratio were performed for each case. Correlation between two tests and accuracy of the test was performed using SPSS V 16. Results:  This study showed protein creatinine ratio is as capable as 24 hours protein urine to diagnose pregnant mother with preeclampsia. Spot P/C ratio provides effortless result with high validity and reliability. Conclusion: This study showed protein creatinine ratio is as capable as 24 hours protein urine to diagnose pregnant mother with preeclampsia. Spot P/C ratio provides effortless result with high validity and reliability. Keywords: Preeclampsia, 24 hours urinary protein, Receiver Operator characteristic curve (ROC), Area under the curve (AUC)

Comparison of 8-h urine protein and random urinary protein-to-creatinine ratio with 24-h urine protein in pregnancy

2011 ◽  
Vol 25 (2) ◽  
pp. 138-140 ◽  
Author(s):  
Soghra Khazardoost ◽  
Maryamnoorzadeh ◽  
Ali Abdollahi ◽  
Masoumeh Shafaat
Keyword(s):  
Urinary Protein ◽  
Creatinine Ratio ◽  
Urine Protein ◽  
In Pregnancy
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