Correction to: Prognostic factors for lymph node metastasis from upper gingival carcinomas

Abstract Background : This study analyzed the effects of four candidate prognostic factors on length of hospital stay among inpatients following thyroid cancer resection; specifically, age ≥ 45 years, cervical lymph node metastasis, impaired calcium metabolism, and postoperative hypothyroidism.Methods : This was a retrospective study reviewing 434 patients’ medical and claim records (n=434; male 21.0%/female 79.0%, age: 57.31±13.52). Results : Patients who met one of the four prognostic criteria were more likely to have a longer hospital stay using acute-care beds than corresponding cases negative for these criteria. Regression analysis indicated that patient’s length of hospital stay was increased with each factor by the following rates: 1) 14.57% if 45 years or older, 2) 26.24% if positive for cervical lymph node metastasis, 3) 28.79% if positive for impaired calcium metabolism, and 4) 29.95% if positive for postoperative hypothyroidism. Moreover, estimations of cumulative probability of length of hospital stay indicate that: 1) 26.6% of the age≥45 patient group is expected to be discharged by the 7 th day in contrast to 42.9% of age<45 patient group (91.0%,97.4% at 14 th day); 2) 16.1% of the cervical lymph node metastasis patient group is expected to be discharged by the 7 th day in contrast with 30.5% of non-patient group (83.9%,92.8% at 14 th day); 3) 14.8% of the impaired calcium metabolism patient group is expected to be discharged by the 7 th day in contrast with 30.5% of non-patient group (70.4%,93.6% at 14 th day), and 4) 21.4% of the postoperative hypothyroidism patient group is expected to be discharged by the 7 th day in contrast with 29.8% of non-patient group (71.4%,92.9% at 14 th day). Conclusions : Disorders of calcium metabolism and postoperative hypothyroidism were the most likely postoperative complications to occur, yet these are not identified as prognostic factors in the Diagnosis Procedure Combination / Per-Diem Payment System (DPC/PDPS) framework in Japan. The findings suggest that patients with these two conditions should receive care in beds of a lower, sub-acute category, and they should be quickly transferred to such beds or, if possible, to outpatient care.

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Prognostic Factors and Lymph Node Metastasis Patterns of Primary Duodenal Cancer

World Journal of Surgery ◽

10.1007/s00268-021-06339-2 ◽

2021 ◽

Author(s):

Kohei Nishio ◽

Kenjiro Kimura ◽

Shimpei Eguchi ◽

Daisuke Shirai ◽

Jun Tauchi ◽

...

Keyword(s):

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Duodenal Cancer ◽

Node Metastasis ◽

Metastasis Patterns

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Prognostic Factors in Canine Mammary Carcinomas and HER2 Expression Relationship

Acta Scientiae Veterinariae ◽

10.22456/1679-9216.79791 ◽

2017 ◽

Vol 45 (1) ◽

pp. 9 ◽

Cited By ~ 1

Author(s):

Nicolle Pereira Soares ◽

Alessandra Aparecida Medeiros ◽

Igor De Paula Castro ◽

Taís Meziara Wilson ◽

Taís De Almeida Moreira ◽

...

Keyword(s):

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Histological Grade ◽

Her2 Expression ◽

Mammary Carcinomas ◽

Node Metastasis ◽

In Situ Carcinoma ◽

Grade Iii

Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histological grade of 97 carcinoma samples was attributed, except in situ carcinoma, 37 (38.14%) of the neoplasms were grade I, 50 (51.55%) grade II and only 10 (10.31%) tumors were classified as grade III. Forty bitches were submitted to clinical staging (TNM) and 42.50% of the bitches received staging in grade I and, 25% of the bitches staged in grade IV and V, with metastases. The HER2 expression, 13/99 samples (13.13%) received score +2, 19/99 (19.19%) score +1 and absence of marking (score 0) was identified in 67 samples (67.80 %). Immunostaining in hyperplastic or normal epithelial cells was evidenced, often in association with weak or moderate cytoplasmic labeling. Of the samples expressing +2 score for HER2 (n = 13), eight samples (17.39%) were complex carcinoma and five (9.80%) simple carcinomas. There was no relationship between HER2 immunostaining with age, tumor size, TNM, histological type, histological gradation, lymph node metastasis and distance. Animals with lymph node metastasis, as well as those diagnosed with distant metastasis, did not present HER2 expression in the tumors.Discussion: The simple carcinoma seems to be the most frequent type histological diagnosed in canine mammary carcinomas, followed by carcinoma in mixed tumor and complex carcinoma. Tubulopapillary carcinomas are more invasive in the female dogs as well as in the woman. Carcinomas grade I and II are more frequent and present a better prognosis for the dog. However, bitches with grade III carcinoma survived for a shorter time when compared to dogs with grade I or II tumors. A factor that may have contributed to the lower number of bitches at worst prognostic stage (EC IV and V) is the current owners’ awareness that they have sought veterinary help earlier, as soon as they detect small nodules in mammary gland. Overexpression of HER2 in women breast cancer is diagnosed in 20-30% of cases, whereas in bitches, this expression is variable. Also the different percentages of canine HER2 immunostaining are due to the lack of standardization for the analysis of the immunostaining, the immunohistochemical techniques employed and the non-specificity of the HER2 antibody. In canine mammary carcinomas the HER2 expression in low and this immunostaining is not related to other established prognostic factors. This study reinforces the hypothesis put forward by other authors that in the bitch the expression of HER2 may not be related to malignancy and tumor progression.

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Prognostic factors associated with radiotherapy for cervical cancer with computed tomography-detected para-aortic lymph node metastasis

Journal of Radiation Research ◽

10.1093/jrr/rrt086 ◽

2013 ◽

Vol 55 (1) ◽

pp. 129-138 ◽

Cited By ~ 7

Author(s):

S.-Y. Wu ◽

E.-Y. Huang ◽

C.-C. Chanchien ◽

H. Lin ◽

C.-J. Wang ◽

...

Keyword(s):

Computed Tomography ◽

Cervical Cancer ◽

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Factors Associated ◽

Node Metastasis ◽

Aortic Lymph Node

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Primary Treatment and Prognostic Factors of Carcinosarcoma of the Ovary, Fallopian Tube, and Peritoneum: A Taiwanese Gynecologic Oncology Group Study

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000000083 ◽

2014 ◽

Vol 24 (3) ◽

pp. 506-512 ◽

Cited By ~ 8

Author(s):

Chien-Hsing Lu ◽

I-Hui Chen ◽

Yi-Jen Chen ◽

Kung-Liahng Wang ◽

Jian-Tai Timothy Qiu ◽

...

Keyword(s):

Overall Survival ◽

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Fallopian Tube ◽

Gynecologic Oncology ◽

Gynecologic Oncology Group ◽

Oncology Group ◽

Node Metastasis ◽

The Mean

ObjectiveThis study aimed to determine the clinical prognostic factors involved in carcinosarcoma of the ovary, fallopian tube, and peritoneum.Materials and MethodsThis retrospective study was undertaken by the Taiwanese Gynecologic Oncology Group. The retrieved clinical data included demographic characteristics, medical disease, tumor status, extent of surgery, and adjuvant chemotherapy.ResultsIn total, 63 patients with carcinosarcoma of the ovary, fallopian tube, and peritoneum were identified. Sixty-one patients with complete data were enrolled for further data analysis. The mean follow-up period was 1.0 year, and the mean overall survival was 15.4 months. By log-rank tests, age, menopausal status, parity, hypertension, diabetes, primary tumor size, para-aortic lymph node metastasis, pretreatment CA-125, preceding diagnostic surgery, hysterectomy, lymphadenectomy, other surgeries, and paclitaxel use were not predictive of overall survival.Omentectomy, no gross residual implants after surgery, platinum treatment, and no pelvic lymph node metastasis had a trend toward better survival. Early diagnosis at stage I and cisplatin/ifosfamide regimen were significant associated with a better overall survival in log-rank and simple Cox regression tests. Bilateral ovarian tumors and metastatic tumors larger than 2 cm were significantly associated with a poorer overall survival.ConclusionsEarly diagnosis at stage I, unilateral ovarian tumor, metastatic tumors less than 2 cm, and cisplatin/ifosfamide regimen were predictive of a better survival.Omentectomy and complete debulking surgery also showed a trend toward better survival. Thus, these treatment strategies should be applied in patients with carcinosarcoma of the ovary, fallopian tube, and peritoneum.

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Outcomes and prognostic factors in patients with a single lymph node metastasis at time of radical cystectomy

BJU International ◽

10.1111/j.1464-410x.2012.11356.x ◽

2012 ◽

Vol 111 (1) ◽

pp. 74-84 ◽

Cited By ~ 22

Author(s):

Michael Rink ◽

Jens Hansen ◽

Eugene K. Cha ◽

David A. Green ◽

Marko Babjuk ◽

...

Keyword(s):

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Radical Cystectomy ◽

Node Metastasis

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An Evaluation of Malignancy and Prognostic Factors Based on Mode of Lymph Node Metastasis in Esophageal Carcinoma

Surgery Today ◽

10.1007/s005950050554 ◽

1999 ◽

Vol 29 (11) ◽

pp. 1131-1135 ◽

Cited By ~ 1

Author(s):

Daisuke Tachikawa ◽

Shigemitsu Inada ◽

Tsuyoshi Kotoh ◽

Kitaro Futami ◽

Sumitaka Arima ◽

...

Keyword(s):

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Esophageal Carcinoma ◽

Node Metastasis

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Characteristics of medullary breast carcinoma compared with invasive ductal carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.27_suppl.20 ◽

2012 ◽

Vol 30 (27_suppl) ◽

pp. 20-20

Author(s):

Inhye Park ◽

Jiyoung Kim ◽

Se-Kyung Lee ◽

Min-Young Choi ◽

Su Yeon Bae ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Invasive Ductal Carcinoma ◽

Tumor Size ◽

Ductal Carcinoma ◽

Histological Grade ◽

Clinicopathologic Features ◽

Node Metastasis

20 Background: Medullary carcinoma (MC) represents a rare breast cancer subtype associated with a rather favorable prognosis compared with invasive ductal carcinoma (IDC). It is characterized by the high-grade structure and lymphocytic infiltration, hemorrhagic necrosis. The purpose of this study is to compare the clinicopathologic characteristics and outcome of MC to IDC. Methods: We retrospectively reviewed the medical records of patients with invasive breast cancer managed with operation at Samsung Medical Center in Korea from January 1995 to June 2010 except patients diagnosed with ductal carcinoma in situ, patients with distant metastasis at diagnosis or neoadjuvant chemotherapy. 52 cases were identified with MC; 5,716 patients with IDC. The clinicopathologic features, disease-free survival (DFS) and overall survival (OS) for patients with MC were compared with those of the IDC patients. Results: The medullary group presented at younger age (43.9 ± 8.8 vs 47.7 ± 9.9, p=0.006). Also the medullary group was significantly associated with higher histological grade (poor; 80.0 vs 38.3%, p=0.003) and nuclear grade (grade3; 82.8 vs 41.7%, p<0.001) as well as negative ER (84.8 vs 31.0%, p<0.001) and PR status (91.3 vs 38.8%, p<0.001) regarded as poor prognostic factors. But lymphatic invasion was rare (0.0 vs 29.8%, p<0.001) and N stage was low (N0; 86.5 vs 58.4%, p<0.001). The DFS and OS were not significantly different between the medullary and IDC groups. (5-yr DFS : 88.0 vs 89.2 %, p=0.917, 5-yr OS : 94.4 vs 93.4%, p=0.502) In multivariable analysis, factors associated with DFS and OS included nuclear grade, histological grade, tumor size, lymph node metastasis, ER/PR/C-erbB2 status, chemotherapy and hormone therapy. When adjusting for other factors, histological type itself did not show significant difference from IDC in DFS and OS. Conclusions: Despite MC present specific clinicopathologic features, prognosis is not different from IDC and determined by already known prognostic factors such as tumor size, lymph node metastasis. Therefore, the patients with MC also need aggressive treatment like IDC.

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