Characteristics of medullary breast carcinoma compared with invasive ductal carcinoma.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 20-20
Author(s):  
Inhye Park ◽  
Jiyoung Kim ◽  
Se-Kyung Lee ◽  
Min-Young Choi ◽  
Su Yeon Bae ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Invasive Ductal Carcinoma ◽  
Tumor Size ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
Clinicopathologic Features ◽  
Node Metastasis

20 Background: Medullary carcinoma (MC) represents a rare breast cancer subtype associated with a rather favorable prognosis compared with invasive ductal carcinoma (IDC). It is characterized by the high-grade structure and lymphocytic infiltration, hemorrhagic necrosis. The purpose of this study is to compare the clinicopathologic characteristics and outcome of MC to IDC. Methods: We retrospectively reviewed the medical records of patients with invasive breast cancer managed with operation at Samsung Medical Center in Korea from January 1995 to June 2010 except patients diagnosed with ductal carcinoma in situ, patients with distant metastasis at diagnosis or neoadjuvant chemotherapy. 52 cases were identified with MC; 5,716 patients with IDC. The clinicopathologic features, disease-free survival (DFS) and overall survival (OS) for patients with MC were compared with those of the IDC patients. Results: The medullary group presented at younger age (43.9 ± 8.8 vs 47.7 ± 9.9, p=0.006). Also the medullary group was significantly associated with higher histological grade (poor; 80.0 vs 38.3%, p=0.003) and nuclear grade (grade3; 82.8 vs 41.7%, p<0.001) as well as negative ER (84.8 vs 31.0%, p<0.001) and PR status (91.3 vs 38.8%, p<0.001) regarded as poor prognostic factors. But lymphatic invasion was rare (0.0 vs 29.8%, p<0.001) and N stage was low (N0; 86.5 vs 58.4%, p<0.001). The DFS and OS were not significantly different between the medullary and IDC groups. (5-yr DFS : 88.0 vs 89.2 %, p=0.917, 5-yr OS : 94.4 vs 93.4%, p=0.502) In multivariable analysis, factors associated with DFS and OS included nuclear grade, histological grade, tumor size, lymph node metastasis, ER/PR/C-erbB2 status, chemotherapy and hormone therapy. When adjusting for other factors, histological type itself did not show significant difference from IDC in DFS and OS. Conclusions: Despite MC present specific clinicopathologic features, prognosis is not different from IDC and determined by already known prognostic factors such as tumor size, lymph node metastasis. Therefore, the patients with MC also need aggressive treatment like IDC.

scholarly journals Process of Lymph Node Metastasis in Invasive Breast Cancer with Squamous Cell Differentiation: A Case Report

2021 ◽  
Author(s):  
MAYU AOKI ◽  
Takaaki Fujii ◽  
CHIKAKO HONDA ◽  
YUKO NAKAZAWA ◽  
MISATO OGINO ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Cell Differentiation ◽  
Lymph Node Metastasis ◽  
Invasive Ductal Carcinoma ◽  
Squamous Cell ◽  
Ductal Carcinoma ◽  
Squamous Differentiation ◽  
Node Metastasis

Abstract BackgroundBreast cancer with squamous differentiation is a relatively rare condition. Clinically, lymph node metastasis is uncommon in metaplastic carcinoma We treated a patient with lymph node metastasis of the ductal carcinoma component of invasive ductal carcinoma with squamous cell differentiation. Case Report: An 84-year-old postmenopausal Japanese woman had a left-breast mass with an enlarged lymph node in the left axilla. A biopsy revealed an invasive ductal carcinoma with squamous cell differentiation. A left mastectomy with axillary lymph node dissection was performed. The Histological evaluation revealed invasive ductal carcinoma with squamous cell differentiation. One lymph node was positive for metastasis consisting of ductal carcinoma without squamous cell differentiation.Conclusion: This case suggests that lymph node metastasis in ductal carcinoma with squamous differentiation may first involve the ductal carcinoma component and then differentiation may occur in the in volved lymph nodes. This is an interesting case highlighting the process of the progression of lymph node metastasis in cases with breast cancer with squamous cell differentiation.

scholarly journals Estrogen Receptors, Progesterone Receptors and their Correlation with respect to HER-2/neu Status, Histological Grade, Size of Lesion, Lymph node Metastasis, Lymphovascular Involvement and Age in Breast Cancer patients in a hospital in north India

2016 ◽  
Vol 7 (3) ◽  
pp. 28-34 ◽  
Author(s):  
Mushood G. Nabi ◽  
Andleeb Ahangar ◽  
Subiya Kaneez
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Hormone Receptor ◽  
Histological Grade ◽  
Low Grade ◽  
Inverse Association ◽  
Node Metastasis ◽  
Her 2

Background: Breast cancer is the second most common cancer overall (1.4 million cases, 10.9%) and ranks 5th as cause of death (458,000. 6.1%).The present study was aimed to find the pattern of expression of ER, PR, HER-2/neu and to correlate ER, PR status with respect to various clinicopathlogical factors like HER-2/neu over expression, histological grade, tumor size, lymphnode metastasis, lymphovascular invasion and age of the patient.Materials and Methods: Data from 139 patients was collected and correlation of ER, PR status with various clinicopathological factors was analysed.Results: Mean age at diagnosis was 48.5 years, 56.8% cases being ?50years of age. Tumor size ranged from 1 to 12 cm. Most lesions (57.5%) were>2 to 5 cm in size. The predominant morphology was Infiltrating Duct carcinoma-NOS (90.6%). Majority of cases presented as grade II(46.7%) lesions and lymph node involvement was seen in 66.9%. 49.6% cases were ER+, 49.6% cases were PR+, and HER-2/neu was positive (3+) in 15.8% cases. Older patients were mostly ER+PR+. Low grade tumors were mostly ER+PR+ as compared to high grade tumors. HER-2/neu status revealed an inverse association with hormone receptor positivity. No correlation was found between hormone receptor positivity and lymph node metastasis. Lymphovascular involvement was noted more in hormone negative ER-PR- tumors.Conclusion:  ER and PR expression in our patients was found to be comparable to the studies done in Indian subcontinent, but lower than studies done in west, but triple negative breast cancer prevalence was relatively higher in our study (34.5%).Asian Journal of Medical Sciences Vol. 7(3) 2016 28-34

scholarly journals The role of microvessel density, lymph node metastasis, and tumor size as prognostic factors of distant metastasis in colorectal cancer

2017 ◽  
Vol 13 (6) ◽  
pp. 4327-4333 ◽  
Author(s):  
Tomonari Cho ◽  
Eisuke Shiozawa ◽  
Fumihiko Urushibara ◽  
Nana Arai ◽  
Toshitaka Funaki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Microvessel Density ◽  
Tumor Size ◽  
Node Metastasis

scholarly journals Prognostic Factors in Canine Mammary Carcinomas and HER2 Expression Relationship

2017 ◽  
Vol 45 (1) ◽  
pp. 9 ◽  
Author(s):  
Nicolle Pereira Soares ◽  
Alessandra Aparecida Medeiros ◽  
Igor De Paula Castro ◽  
Taís Meziara Wilson ◽  
Taís De Almeida Moreira ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Histological Grade ◽  
Her2 Expression ◽  
Mammary Carcinomas ◽  
Node Metastasis ◽  
In Situ Carcinoma ◽  
Grade Iii

Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histological grade of 97 carcinoma samples was attributed, except in situ carcinoma, 37 (38.14%) of the neoplasms were grade I, 50 (51.55%) grade II and only 10 (10.31%) tumors were classified as grade III. Forty bitches were submitted to clinical staging (TNM) and 42.50% of the bitches received staging in grade I and, 25% of the bitches staged in grade IV and V, with metastases. The HER2 expression, 13/99 samples (13.13%) received score +2, 19/99 (19.19%) score +1 and absence of marking (score 0) was identified in 67 samples (67.80 %). Immunostaining in hyperplastic or normal epithelial cells was evidenced, often in association with weak or moderate cytoplasmic labeling. Of the samples expressing +2 score for HER2 (n = 13), eight samples (17.39%) were complex carcinoma and five (9.80%) simple carcinomas. There was no relationship between HER2 immunostaining with age, tumor size, TNM, histological type, histological gradation, lymph node metastasis and distance. Animals with lymph node metastasis, as well as those diagnosed with distant metastasis, did not present HER2 expression in the tumors.Discussion: The simple carcinoma seems to be the most frequent type histological diagnosed in canine mammary carcinomas, followed by carcinoma in mixed tumor and complex carcinoma. Tubulopapillary carcinomas are more invasive in the female dogs as well as in the woman. Carcinomas grade I and II are more frequent and present a better prognosis for the dog. However, bitches with grade III carcinoma survived for a shorter time when compared to dogs with grade I or II tumors. A factor that may have contributed to the lower number of bitches at worst prognostic stage (EC IV and V) is the current owners’ awareness that they have sought veterinary help earlier, as soon as they detect small nodules in mammary gland. Overexpression of HER2 in women breast cancer is diagnosed in 20-30% of cases, whereas in bitches, this expression is variable. Also the different percentages of canine HER2 immunostaining are due to the lack of standardization for the analysis of the immunostaining, the immunohistochemical techniques employed and the non-specificity of the HER2 antibody. In canine mammary carcinomas the HER2 expression in low and this immunostaining is not related to other established prognostic factors. This study reinforces the hypothesis put forward by other authors that in the bitch the expression of HER2 may not be related to malignancy and tumor progression.

Increased soluble CD44 concentrations are associated with larger tumor size and lymph node metastasis in breast cancer patients

2008 ◽  
Vol 134 (11) ◽  
pp. 1229-1235 ◽  
Author(s):  
Sebastian Mayer ◽  
Axel zur Hausen ◽  
Dirk Otto Watermann ◽  
Stefan Stamm ◽  
Markus Jäger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Tumor Size ◽  
Breast Cancer Patients ◽  
Node Metastasis ◽  
Soluble Cd44
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