Synthesis and Biological Evaluation of Cyclic [99mTc]-HYNIC-CGPRPPC as a Fibrin-Binding Peptide for Molecular Imaging of Thrombosis and Its Comparison with [99mTc]-HYNIC-GPRPP

2016 ◽  
Vol 19 (2) ◽  
pp. 256-264 ◽  
Author(s):  
Sedigheh Rezaeianpour ◽  
Atefeh Hajiagha Bozorgi ◽  
Abolghasem Moghimi ◽  
Ameneh Almasi ◽  
Saeed Balalaie ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Biological Evaluation ◽  
Binding Peptide ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy

2021 ◽  
Author(s):  
Koichi Sasaki ◽  
Kyohei Muguruma ◽  
Rento Osawa ◽  
Akane Fukuda ◽  
Atsuhiko Taniguchi ◽  
...  
Keyword(s):  
Immune Response ◽  
Cancer Cells ◽  
Nk Cell ◽  
Folate Receptor ◽  
Biological Evaluation ◽  
Binding Peptide ◽  
Simple Preparation ◽  
Cell Mediated Immune Response ◽  
Binding Antibody ◽  
Synthesis And Biological Evaluation

A monocyclic Fc-binding peptide “15-Lys8Leu” enables simple preparation of a Fc-binding antibody-recruiting molecule (Fc-ARM), which induces potent cytotoxicity against folate receptor positive cancer cells via NK cell-mediated immune response.

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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