Chronic co-exposure to chlorpyrifos and deltamethrin pesticides induces alterations in serum lipids and oxidative stress in Wistar rats: mitigating role of alpha-lipoic acid

2018 ◽  
Vol 25 (20) ◽  
pp. 19605-19611 ◽  
Author(s):  
Chidiebere Uchendu ◽  
Suleiman Folorunsho Ambali ◽  
Joseph Olusegun Ayo ◽  
King Akpofure Nelson Esievo
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Wistar Rats ◽  
Serum Lipids ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

scholarly journals AMELIORATIVE ROLE OF ALPHA LIPOIC ACID ON PARACETAMOL INDUCED RENAL TOXICITY AND OXIDATIVE STRESS IN RATS

2019 ◽  
Vol 19 (1) ◽  
pp. 87-106
Author(s):  
Sara kasem ◽  
maha Hilal ◽  
Reda Elsayed ◽  
sheren mahmoud ◽  
amany abdallah
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Renal Toxicity ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs

2016 ◽  
Vol 80 ◽  
pp. 63-72 ◽  
Author(s):  
Huimin Hu ◽  
Changyuan Wang ◽  
Yue Jin ◽  
Qiang Meng ◽  
Qi Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

scholarly journals The role of oxidative stress and effect of alpha-lipoic acid in reexpansion pulmonary edema – an experimental study

2010 ◽  
Vol 6 ◽  
pp. 848-853 ◽  
Author(s):  
Seyfettin Gumus ◽  
Orhan Yucel ◽  
Mehmet Gamsizkan ◽  
Ayse Eken ◽  
Omer Deniz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Study ◽  
Pulmonary Edema ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Reexpansion Pulmonary Edema

scholarly journals The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Biology ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 239
Author(s):  
Fatma M. Ghoneim ◽  
Hani Alrefai ◽  
Ayman Z. Elsamanoudy ◽  
Salwa M. Abo El-khair ◽  
Hanaa A. Khalaf
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Lipoic Acid ◽  
Caspase 3 ◽  
Protective Role ◽  
Alpha Lipoic Acid ◽  
Group Iii ◽  
Rat Offspring ◽  
Group I

Background: Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration of VPA on the pancreas of rat offspring and assess the potential protective role of ALA co-administration during pregnancy. Methods: Twenty-eight pregnant female albino rats were divided into four groups: group I (negative control), group II (positive control, ALA treated), group III (VPA-treated), and group IV (VPA-ALA-treated). The pancreases of the rat offspring were removed at the fourth week postpartum and prepared for histological, immune-histochemical, morphometric, molecular, and oxidative stress marker studies. Results: In group III, there were pyknotic nuclei, vacuolated cytoplasm with ballooning of acinar, α, and β cells of the pancreas. Ultrastructural degeneration of cytoplasmic organelles was detected. Additionally, there was a significant increase in oxidative stress, a decrease in insulin-positive cell percentage, and an increase in glucagon positive cells in comparison to control groups. Moreover, VPA increased the gene expression of an apoptotic marker, caspase-3, with a decrease in anti-apoptotic Bcl2 and nuclear factor erythroid 2-related factor 2 (Nrf2) transcriptional factor. Conversely, ALA improved oxidative stress and apoptosis in group VI, and a consequent improvement of the histological and ultrastructure picture was detected. Conclusion: ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2. Administration of α-lipoic acid has a protective effect against VPA-induced pancreatic oxidative damage via its cytoprotective antioxidant effect.

scholarly journals Alpha - Lipoic Acid Decreases DNA Damage and Oxidative Stress Induced by Alcohol in the Developing Hippocampus and Cerebellum of Rat

2008 ◽  
Vol 22 (5-6) ◽  
pp. 769-776 ◽  
Author(s):  
Alireza Shirpoor ◽  
Syranush Minassian ◽  
Siamak Salami ◽  
Mohammad Hassan Khadem-Ansari ◽  
Marine Yeghiazaryan
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid

2018 ◽  
Vol 449 (1-2) ◽  
pp. 267-276 ◽  
Author(s):  
Navid Nobakht-Haghighi ◽  
Mahban Rahimifard ◽  
Maryam Baeeri ◽  
Mohammad Amin Rezvanfar ◽  
Shermineh Moini Nodeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Islets ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress
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