Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy

Magnesium (Mg) and potassium (K) are the major intracellular cations whose presence in the serum are low, but minor changes of those may show a remarkable change in the various body functions specially in the heart. The study was designed to find out the correlation between serum Mg and K in acute myocardial infarction (AMI), chronic ischemic heart disease (CIHD) and normal healthy volunteers. It was carried out over a period of 18 months in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU) in collaboration with Department of Cardiology, Sir Salimullah Medical College & Mitford Hospital (SSMC & MH) and Atomic Energy Center, Dhaka. A total of 101 subjects were included in which 32 subjects were AMI, 34 CIHD and 35 normal healthy volunteers. Serum glucose and serum creatinine were estimated to exclude diabetes and renal dystrophies. Estimation of serum CK-MB and ECG tracing were done as diagnostic tools of AMI and to categories the subjects into various groups. Serum Mg was estimated by Atomic absorption spectrophotometer and serum K by Ion sensitive electrode. The present study shows that there is a strong positive correlation of serum Mg and K in AMI, CIHD and healthy control subjects (r = 0.566, p<0.01 level). So it is suggested to estimate and supplement both Mg and K in IHD patients for their better management. DOI: http://dx.doi.org/10.3329/bjmb.v3i2.13812 Bangladesh J Med Biochem 2010; 3(2): 50-56

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Impact of chronic ischemic heart disease on severe maternal morbidity during delivery hospitalizations

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2021.11.146 ◽

2022 ◽

Vol 226 (1) ◽

pp. S77

Author(s):

Anna Denoble ◽

Sarah Goldstein ◽

Chad Grotegut ◽

Jerome Federspiel

Keyword(s):

Heart Disease ◽

Ischemic Heart Disease ◽

Maternal Morbidity ◽

Ischemic Heart ◽

Severe Maternal Morbidity ◽

Chronic Ischemic Heart Disease

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Dynamics of clinical picture, morphofunctional parameters of myocardium and adherence to treatment at conservative and surgical treatment of chronic ischemic heart disease

JOURNAL of SIBERIAN MEDICAL SCIENCES ◽

10.31549/2542-1174-2019-3-52-62 ◽

2019 ◽

pp. 52-62

Author(s):

D.А. Yakhontov ◽

◽

A.V. Zvonkova ◽

Keyword(s):

Heart Disease ◽

Surgical Treatment ◽

Ischemic Heart Disease ◽

Clinical Picture ◽

Ischemic Heart ◽

Adherence To Treatment ◽

Chronic Ischemic Heart Disease ◽

Conservative And Surgical Treatment

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Abstract 10958: Identification of Right Ventricular Myocardial Infarction With Late Gadolinium Enhancement in Chronic Ischemic Heart Disease: Comparison With Pathological Findings

Circulation ◽

10.1161/circ.132.suppl_3.10958 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

Yan Chaowu ◽

Li Li ◽

Fang Wei ◽

Li Hua ◽

Wang Yang

Keyword(s):

Myocardial Infarction ◽

Heart Disease ◽

Late Gadolinium Enhancement ◽

Ischemic Heart Disease ◽

Ischemic Heart ◽

Pathological Findings ◽

Chronic Ischemic Heart Disease ◽

Gadolinium Enhancement ◽

Right Ventricular Myocardial Infarction ◽

Replacement Fibrosis

Introduction: Late gadolinium enhancement (LGE) has the potential to become an excellent technique in the diagnosis of right ventricular myocardial infarction (RVMI). However, the gold standard, pathological findings from patients, is still unavailable to validate the true value of LGE. Hypothesis: We hypothesized that LGE might correspond with histological infarction in RVMI. Methods: 36 transplant candidates (35 M /1F) with chronic ischemic heart disease were studied prospectively with LGE. According to the 12-segment-model, the pathological findings of RV were compared with the previous in vivo LGE after heart transplantation. Results: Histological RVMI was detected in 7 patients, and corresponded with all LGE segments (n=23) and 2 non-LGE segments. A generalize linear mix effect model showed non-significant difference (P=0.152) between the results of LGE and histological infraction. In identifying the RV segments with histological infarction, sensitivity and specificity of LGE was 92.0% (95%CI 74.0% to 99.0%) and 100% (95%CI 99.9% to 100.0%), respectively. Furthermore, RV segments without LGE mainly included two pathological patterns: histologically normal myocardium (n=372) or the admixture of viable myocardium and scattered replacement fibrosis (n=35). In the non-LGE RV segments, wall motion abnormality was associated with volume fraction of collagen (11.4±6.5% vs 4.3±2.2%, P<0.001) and the presence of ischemia (96.4% vs 1.7%, P<0.001). Conclusions: The RV segments with LGE corresponded closely with histological infarction in ischemic heart disease. However, RV segments without LGE might be histologically normal myocardium or intermixed with scattered replacement fibrosis. Further studies are required to evaluate the significance of scattered replacement fibrosis in the non-LGE segments.

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Serum Lipids Profiling Perturbances in Patients with Ischemic Heart Disease and Ischemic Cardiomyopathy

10.21203/rs.2.19569/v3 ◽

2020 ◽

Author(s):

Lin Yang ◽

Liang Wang ◽

Yangyang Deng ◽

Lizhe Sun ◽

Bowen Low ◽

...

Keyword(s):

Heart Disease ◽

Ischemic Heart Disease ◽

Ischemic Cardiomyopathy ◽

Serum Lipids ◽

Ischemic Heart ◽

Negative Ion ◽

Serum Samples ◽

Cross Sectional ◽

Negative Ion Mode ◽

Positive Ion

Abstract Background: Ischemic heart disease (IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in these patients. Methods: In this cross-sectional study, we analyzed serum lipids profile in IHD and ICM patients using a lipidomics approach. Consecutive consenting patients admitted to the hospital for IHD and ICM were enrolled. Serum samples were obtained after overnight fasting. Non-targeted metabolomics was applied to demonstrate lipids metabolic profile in control, IHD and ICM patients. Results: A total of 63 and 62 lipids were detected in negative and positive ion mode respectively. Among them, 16:0 Lyso PI, 18:1 Lyso PI in negative ion mode, and 19:0 Lyso PC, 12:0 SM d18:1/12:0, 15:0 Lyso PC, 17:0 PC, 18:1-18:0 PC in positive ion mode were significantly altered both in IHD and ICM as compared to control. 13:0 Lyso PI, 18:0 Lyso PI, 16:0 PE, 14:0 PC DMPC, 16:0 ceramide, 18:0 ceramide in negative ion mode, and 17:0 PE, 19:0 PC, 14:0 Lyso PC, 20:0 Lyso PC, 18:0 PC DSPC, 18:0-22:6 PC in positive ion mode were significantly altered only in ICM as compared to IHD and control. Conclusion: Using non-targeted lipidomics profiling, we have successfully identified a group of circulating lipids that were significantly altered in IHD and ICM. The lipids metabolic signatures shed light on potential new biomarkers and therapeutics for preventing and treating ICM.

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