Traditionally, flood management has concentrated on providing protection against floods using technical measures, but there is currently an international shift towards a more integrated system of flood risk management, whereby flood risk is defined as the probability of flooding multiplied by the potential consequences. Climate change is a great challenge to sustainable development and the Millennium Development Goals (MDGs) in Thailand. The main purpose of this paper is to highlight the challenges associated with the current situation and projected impacts of climate change on the disasters and the human environment in Thailand, to review and explore the potential of Strategic Environmental Assessment (SEA), and to propose SEA in making informed decisions relevant to the implementation of the new adaptation framework in a flood management plan. Thus, current measures on how Thailand is responding to the recent impacts of climate change in river basin planning are presented. It is imperative that an appropriate environmental assessment tool, such as SEA be employed in making rational decisions regarding adaptation frameworks. SEA offers a structured and proactive environmental tool for integrating of climate change adaption into formulating Policies, Plans, and Programs (PPPs) among relevant sectors.