<p>By analyzing the seismicity in the new time domain termed natural time [1],&#160; the entropy changes of seismicity before major earthquakes have been studied. It was found [2-5] that the key quantity is the entropy change &#916;S under time reversal, which is minimized a few months before major earthquakes such as the M9.0 Tohoku earthquake [2] on 11 March 2011 and the M8.2 Chiapas earthquake [3] in Mexico on 7 September 2017; accompanied by an abrupt increase of its fluctuations [4,5]. Here we discuss how these fluctuations may lead to a procedure through which the occurrence time of an impending mainshock can be estimated [6].</p><p>References</p><p>1. Varotsos P.A., Sarlis N.V. and Skordas E.S., <em>Natural Time Analysis: The new view of time. Precursory Seismic Electric Signals, Earthquakes and other Complex Time-Series</em> (Springer-Verlag, Berlin Heidelberg) 2011.</p><p>2. N. V. Sarlis, E. S. Skordas, and P. A. Varotsos, "A remarkable change of the entropy of seismicity in natural time under time reversal before the super-giant M9 Tohoku earthquake on 11 March 2011", EPL (Europhysics Letters), 124 (2018), 29001.</p><p>3. N. V. Sarlis, E. S. Skordas P. A. Varotsos, A. Ram&#237;rez-Rojas, E. L. Flores-M&#225;rquez, "Natural time analysis: On the deadly Mexico M8.2 earthquake on 7 September 2017", Physica A 506 (2018), 625-634.</p><p>4. P. A. Varotsos, N. V. Sarlis and E. S. Skordas, "Tsallis Entropy Index q and the Complexity Measure of Seismicity in Natural Time under Time Reversal before the M9 Tohoku Earthquake in 2011", Entropy 20 (2018), 757.</p><p>5. A. Ram&#237;rez-Rojas, E. L. Flores-M&#225;rquez, N. V. Sarlis and P. A. Varotsos, "The Complexity Measures Associated with the Fluctuations of the Entropy in Natural Time before the Deadly M&#233;xico M8.2 Earthquake on 7 September 2017", Entropy 20 (2018), 477.</p><p>6. E. S. Skordas, N. V. Sarlis and P. A. Varotsos &#8220;Identifying the occurrence time of an impending major earthquake by means of the fluctuations of the entropy change under time reversal&#8221;, EPL (Europhysics Letters), <em>in press</em>.</p>