Effect of chinese herbal medicine for calming Gan (肝) and suppressing hyperactive yang on arterial elasticity function and circadian rhythm of blood pressure in patients with essential hypertension

Background. Chinese herbs are potentially effective for hypertension. Qi Ju Di Huang Wan (QJDHW) is a commonly used Chinese herbal medicine as a monotherapy or in combination with other antihypertensive agents for the treatment of essential hypertension (EH). However, there is no critically appraised evidence such as systematic reviews or meta-analyses on the effectiveness and safety of QJDHW for EH.Methods and Findings. CENTRAL, PubMed, CBM, CNKI, VIP, and online clinical trial registry websites were searched for published and unpublished randomized controlled trials (RCTs) of QJDHW for essential hypertension up to January 2013 with no language restrictions. A total of 10 randomized trials involving 1024 patients were included. Meta-analysis showed that QJDHW combined with antihypertensive drugs was more effective in lowering blood pressure and improving TCM syndrome for the treatment of essential hypertension than antihypertensive drugs used alone. No trials reported severe adverse events related to QJDHW.Conclusions. Our review suggests that QJDHW combined with antihypertensive drugs might be an effective treatment for lowering blood pressure and improving symptoms in patients with essential hypertension. However, the finding should be interpreted with caution because of the poor methodological quality of included trials. There is an urgent need for well-designed, long-term studies to assess the effectiveness of QJDHW in the treatment of essential hypertension.

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The effect of Chinese herbal medicine Jian Ling Decoction for the treatment of essential hypertension: a systematic review

BMJ Open ◽

10.1136/bmjopen-2014-006502 ◽

2015 ◽

Vol 5 (2) ◽

pp. e006502-e006502 ◽

Cited By ~ 6

Author(s):

X. Xiong ◽

P. Wang ◽

X. Li ◽

Y. Zhang

Keyword(s):

Systematic Review ◽

Essential Hypertension ◽

Herbal Medicine ◽

Chinese Herbal Medicine ◽

Chinese Herbal

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Chinese Herbal Medicine Bushen Qinggan Formula for Blood Pressure Variability and Endothelial Injury in Hypertensive Patients: A Randomized Controlled Pilot Clinical Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/804171 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Chunxiao Wu ◽

Jingchun Zhang ◽

Yingke Zhao ◽

Jing Chen ◽

Yue Liu

Keyword(s):

Blood Pressure ◽

Herbal Medicine ◽

Endothelial Function ◽

Chinese Herbal Medicine ◽

Blood Pressure Variability ◽

Endothelial Injury ◽

Control Group ◽

Therapeutic Effects ◽

Chinese Herbal ◽

Significant Difference

Background.Blood pressure variability (BPV) independent of average blood pressure is related to cardiovascular damage. Meanwhile, BPV is also associated with measures of endothelial injury. Decoction, a traditional used form of Traditional Chinese Medicine (TCM), is inconvenient to prepare, carry, and store. Dispensing granules is now developing as an alternative to decoction, but the evidence supporting its clinical efficacy the same as decoction remains unclear.Objective.To examine the therapeutic effects on mean blood pressure (MBP), blood pressure variability, and endothelial function by giving Bushen Qinggan Formula, a compound Chinese Herbal Medicine and also to evaluate the difference in efficacy between decoction and granule.Methods.A total of 150 patients with hypertension were enrolled and randomly assigned to receive the placebo, Bushen Qinggan decoction, or Bushen Qinggan granule in addition to the standard medications (amlodipine-5 mg/d) for the treatment of essential hypertension (EH). The outcome was the reduction in the MBP and BPV and also included changes in the endothelial markers including endothelin-1 (ET-1) and nitric oxide (NO) after 8 weeks of treatment.Results.Compared with the control group, the Bushen Qinggan decoction and granule groups had significant improvement (P<0.01) in BPV and endothelial founction. The level of BPV and endothelial function between decoction and granule group had no significant difference (P>0.05).Conclusion.Based on the standard treatment, Bushen Qinggan Formula further improved BPV and endothelial function. The efficacy of Bushen Qinggan decoction and granule is similar in improving BPV and endothelial function. However, no significant antihypertensive effects could be demonstrated.

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Chinese Herbal Medicine for the Treatment of Obesity-Related Hypertension

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/757540 ◽

2013 ◽

Vol 2013 ◽

pp. 1-11 ◽

Cited By ~ 3

Author(s):

Jie Wang ◽

Bo Feng ◽

Xingjiang Xiong

Keyword(s):

Blood Pressure ◽

Herbal Medicine ◽

Chinese Herbal Medicine ◽

Western Medicine ◽

Methodological Quality ◽

Randomized Clinical Trials ◽

Data Extraction ◽

Combination Group ◽

Chinese Herbal ◽

Positive Results

Objectives. To assess the clinical evidence of Chinese herbal medicine (CHM) for obesity-related hypertension. Search Strategy. Electronic databases were searched until January, 2013.Inclusion Criteria. We included randomized clinical trials (RCTs) testing CHM against nondrug therapy and conventional western medicine, or combined with conventional western medicine against conventional western medicine.Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards.Results. 11 trials were included. Methodological quality was evaluated as low. 1 trial investigated the efficacy of CHM plus nondrug therapy versus nondrug therapy. Positive results in diastolic blood pressure (DBP) (WMD: −5.40 [-5.88,-4.92];P<0.00001) were found in combination group. 1 trial investigated the efficacy of CHM versus conventional western medicine. Positive results in systolic blood pressure (SBP) (WMD: −1.39 [-2.11,-0.67];P=0.0002) were found in CHM. 9 trials investigated the efficacy of CHM plus conventional western medicine versus conventional western medicine. Positive results in SBP (WMD: -6.71 [-11.08,-1.25];P=0.02) were found in combination group. The safety of CHM is unknown.Conclusions. No definite conclusion could be got due to poor methodological quality. Rigorously designed trials are warranted to confirm these results.

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