Hand grip strength and its correlation with vitamin D in Indian patients with hip fracture

Background: Admitted bedridden older patients are at risk of the development of sarcopenia during hospital stay (incident sarcopenia). The objective of this study was to assess the factors associated with sarcopenia (incident and chronic) and its impact on mortality in older people with hip fracture. Methods: A multicenter, pragmatic, prospective observational study was designed. Older subjects with hip fracture admitted to two rehabilitation units were included. Sarcopenia was assessed at admission and at discharge according to the revised EWGSOP (European Working Group on Sarcopenia in Older People) consensus definition. The mortality was evaluated after 7 years of follow-up. Results: A total of 187 subjects (73.8% women) age 85.2 ± 6.3 years were included. Risk factors associated to incident and chronic sarcopenia were undernutrition (body mass index—BMI and Mini Nutritional Assessment−Short Form—MNA-SF), hand-grip strength and skeletal muscle index. During follow-up 114 patients died (60.5% sarcopenic vs. 39.5% non-sarcopenic, p = 0.001). Cox regression analyses showed that factors associated to increased risk of mortality were sarcopenia (HR: 1.67, 95% CI 1.11–2.51) and low hand-grip strength (HR: 1.76, 95% CI 1.08–2.88). Conclusions: Older patients with undernutrition have a higher risk of developing sarcopenia during hospital stay, and sarcopenic patients have almost two times more risk of mortality than non-sarcopenic patients during follow-up after hip fracture.

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Seven-month Wintertime Supplementation of 1200 IU Vitamin D Has No Effect on Hand Grip Strength in Young, Physically Active Males: A Randomized, Controlled Study.

10.21203/rs.3.rs-660114/v1 ◽

2021 ◽

Author(s):

Leho Rips ◽

Alar Toom ◽

Rein Kuik ◽

Ahti Varblane ◽

Hanno Mölder ◽

...

Keyword(s):

Vitamin D ◽

Grip Strength ◽

Intervention Group ◽

Winter Season ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Hand Grip Strength ◽

Control Group ◽

Serum Vitamin D ◽

Hand Grip

Abstract BackgroundThere has been a growing interest in the role of vitamin D for the well-being and physical performance of humans; however, there is a lack of long-term supplementation studies performed on members of the young, physically active, male population.The hypothesis of the study was that vitamin D supplementation during wintertime will decrease the prevalence of critically low vitamin D blood serum levels and increase hand grip strength during the winter season among young male conscripts. Study DesignLongitudinal, triple-blinded, randomized, placebo-controlled trial. MethodsFifty-three male conscripts from the Estonian Army were randomized into two groups: 27 to an intervention group and 26 to a placebo group. The groups were comparable in terms of their demographics. The intervention group received 1200 IU (30 µg) capsules of vitamin D3 and the control group received placebo oil capsules once per day. The length of the follow-up was seven months, from October 2016 until April 2017. Blood serum vitamin D (25(OH)D), parathyroid hormone (PTH), calcium (Ca), ionized calcium (Ca-i), testosterone and cortisol values and hand grip strength were measured four times during the study period. ResultsThe mean 25(OH)D level decreased significantly in the control group to a critically low level during the study, with the lowest mean value of 22 nmol/l found in March 2017. At that time point, 65% in the control group vs 15% in the intervention group had 25(OH)D values of less than 25 nmol/l (p < 0.001). In the intervention group the levels of 25(OH)D did not change significantly during the study period. All other blood tests revealed no significant differences at any time point. The corresponding result was found for hand grip strength at all time points. ConclusionLong-term vitamin D supplementation during wintertime results in fewer conscripts in the Estonian Army with critically low serum vitamin D (25(OH)D) levels during the winter season. However, this did not influence their physical performance in the form of the hand grip strength test. Trial registrationClinicalTrials.gov Identifier: NCT04359524. Registered 20 April 2020 - Retrospectively registered. https://register.clinicaltrials.gov

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S-25OHD Is Associated With Hand Grip Strength and Myopathy at 5 Years in Girls: An Odense Child Cohort Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2018-00281 ◽

2018 ◽

Vol 103 (7) ◽

pp. 2630-2639 ◽

Cited By ~ 2

Author(s):

Rada Faris Al-Jwadi ◽

Eva Jespersen ◽

Christine Dalgård ◽

Niels Bilenberg ◽

Henrik Thybo Christesen

Keyword(s):

Vitamin D ◽

Muscle Strength ◽

Grip Strength ◽

Body Fat ◽

Population Based ◽

Hand Grip Strength ◽

Body Fat Percentage ◽

Fat Percentage ◽

Hydroxyvitamin D ◽

Hand Grip

Abstract Context Severe vitamin D deficiency may lead to myopathy in adults. Little is known about vitamin D and muscle strength in children. Objective To test whether hand grip strength (HGS) in 5-year-old children is associated with serum 25-hydroxyvitamin D (S-25OHD). Design Observational study in the population-based Odense Child Cohort, Denmark. At 5 years, anthropometrics, body fat percentage by skinfold measurements, HGS (n = 881), and S-25OHD2+3 (n = 499) were obtained. Results Mean (SD) HGS was higher for boys compared with girls [8.76 (1.76) vs 8.1 (1.64) kg, P < 0.001]. Mean (SD) 5-year S-25OHD was 70.7 (24.5) nmol/L. HGS was directly associated with height in girls and with weight (directly) and body fat percentage (inversely) in both sexes (P < 0.01 for all). In girls, 5-year S-25OHD was associated with HGS, adjusting for height, weight, and body fat percentage [β = 0.011 (95% CI: 0.004; 0.019), P = 0.003]. S-25OHD ≥75 nmol/L was associated with higher HGS compared with values <50 nmol/L [adjusted β = 0.783 (95% CI: 0.325; 1.241), P = 0.001]. The odds of having myopathy (HGS <10th percentile) were reduced by approximately 70% for S-25OHD ≥50 vs <50 nmol/L [adjusted OR: 0.310 (95% CI: 0.126; 0.762), P = 0.011]. No associations were seen for boys. Pregnancy or umbilical cord S-25OHD did not associate with 5-year HGS. Conclusions Five-year S-25OHD was independently associated with HGS and myopathy in girls but not in boys. Muscle strength may be dependent on vitamin D status even in the higher range in preschool girls. The sex difference remains unexplained.

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The association between decreased hand grip strength and hip fracture in older people: A systematic review

Experimental Gerontology ◽

10.1016/j.exger.2018.06.022 ◽

2018 ◽

Vol 111 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Katharina Denk ◽

Sheila Lennon ◽

Susan Gordon ◽

Ruurd Lucas Jaarsma

Keyword(s):

Systematic Review ◽

Hip Fracture ◽

Older People ◽

Grip Strength ◽

Hand Grip Strength ◽

Hand Grip

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Can early assessment of hand grip strength in elderly hip fracture patients predict functional outcome?

10.1101/557371 ◽

2019 ◽

Author(s):

Ivan Selakovic ◽

Emilija Dubljanin-Raspopovic ◽

Ljiljana Markovic-Denic ◽

Vuk Marusic ◽

Andja Cirkovic ◽

...

Keyword(s):

Hip Fracture ◽

Functional Outcome ◽

Grip Strength ◽

Functional Recovery ◽

Multivariate Regression ◽

Cognitive Status ◽

Hand Grip Strength ◽

Early Assessment ◽

Hand Grip

AbstractDecreased muscle strength is not only a risk factor for hip fracture in elderly patients, but plays a role in recovery of physical function. Our aim was to assess the role of grip strength measured early after hip fracture, and classified according to the EWGSOP2 criteria in predicting short- and long-term functional recovery. One hundred ninety-one patients with acute hip fracture consecutively admitted to an orthopaedic hospital have been selected. A multidimensional geriatric assessment evaluating sociodemographic variables, cognitive status, functional status and quality of life prior to fracture, as well as perioperative variables were performed. Follow-ups at 3 and 6 months after surgery were carried out to evaluate functional recovery. Multivariate regression models were used to assess the predictive role of handgrip strength. The mean age of the participants was 80.3 ±6.8 years. Thirty-five percent of our patients with clinically relevant hand grip strength weakness were significantly older, more often female, had a lower BMI, and were of worse physical health. They also had a lower cognitive level, lower Barthel index, and lower EQ5D scores before fracture. Multivariate regression analysis adjusted for age and gender revealed that hand grip weakness was an independent predictor of worse functional outcome at 3 and 6 months after hip fracture for both genders and in all age populations. Our study supports the prognostic role of hand grip strength assessed at hospital admission in patients with hip fracture. Thus, clinicians should be encouraged to include hand grip assessment in their evaluation of hip fracture patients in the acute setting in order to optimize treatment of high-risk individuals.

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