Abnormal global-brain functional connectivity and its relationship with cognitive deficits in drug-naive first-episode adolescent-onset schizophrenia

2022 ◽  
Author(s):  
Jin Zhao ◽  
Yan Zhang ◽  
Feng Liu ◽  
Jindong Chen ◽  
Jingping Zhao ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Deficits ◽  
First Episode ◽  
Drug Naïve ◽  
Global Brain ◽  
Brain Functional Connectivity

scholarly journals Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Pan Pan ◽  
Yan Qiu ◽  
Ziwei Teng ◽  
Sujuan Li ◽  
Jing Huang ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Functional Connectivity ◽  
Inferior Frontal Gyrus ◽  
First Episode ◽  
Support Vector ◽  
Potential Biomarker ◽  
Drug Naïve ◽  
Pars Triangularis ◽  
Global Brain

Objectives. Previous researches have demonstrated that abnormal functional connectivity (FC) is associated with the pathophysiology of bipolar disorder (BD). However, inconsistent results were obtained due to different selections of regions of interest in previous researches. This study is aimed at examining voxel-wise brain-wide functional connectivity (FC) alterations in the first-episode, drug-naive patient with BD in an unbiased way. Methods. A total of 35 patients with BD and 37 age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI). Global-brain FC (GFC) was applied to analyze the image data. Support vector machine (SVM) was adopted to probe whether GFC abnormalities could be used to identify the patients from the controls. Results. Patients with BD exhibited increased GFC in the left inferior frontal gyrus (LIFG), pars triangularis and left precuneus (PCu)/superior occipital gyrus (SOG). The left PCu belongs to the default mode network (DMN). Furthermore, increased GFC in the LIFG, pars triangularis was positively correlated with the triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) and negatively correlated with the scores of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) coding test and Stroop color. Increased GFC values in the left PCu/SOG can be applied to discriminate patients from controls with preferable sensitivity (80.00%), specificity (75.68%), and accuracy (77.78%). Conclusions. This study found increased GFC in the brain regions of DMN; LIFG, pars triangularis; and LSOG, which was associated with dyslipidemia and cognitive impairment in patients with BD. Moreover, increased GFC values in the left PCu/SOG may be utilized as a potential biomarker to differentiate patients with BD from controls.

Altered intrinsic brain functional connectivity in drug-naïve Parkinson’s disease patients with LRRK2 mutations

2018 ◽  
Vol 675 ◽  
pp. 145-151 ◽  
Author(s):  
Yanbing Hou ◽  
Chunyan Luo ◽  
Jing Yang ◽  
Ruwei Ou ◽  
Wei Song ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Drug Naïve ◽  
Brain Functional Connectivity

scholarly journals Disrupted asymmetry of inter- and intra-hemispheric functional connectivity in patients with drug-naive, first-episode schizophrenia and their unaffected siblings

EBioMedicine ◽  
2018 ◽  
Vol 36 ◽  
pp. 429-435 ◽  
Author(s):  
Furong Zhu ◽  
Feng Liu ◽  
Wenbin Guo ◽  
Jindong Chen ◽  
Qinji Su ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
First Episode ◽  
Drug Naïve ◽  
First Episode Schizophrenia
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