Gastric Fistula After Sleeve Gastrectomy: Clinical Features and Treatment Options

SUMMARY The exfoliative (epidermolytic) toxins of Staphylococcus aureus are the causative agents of the staphylococcal scalded-skin syndrome (SSSS), a blistering skin disorder that predominantly affects children. Clinical features of SSSS vary along a spectrum, ranging from a few localized blisters to generalized exfoliation covering almost the entire body. The toxins act specifically at the zona granulosa of the epidermis to produce the characteristic exfoliation, although the mechanism by which this is achieved is still poorly understood. Despite the availability of antibiotics, SSSS carries a significant mortality rate, particularly among neonates with secondary complications of epidermal loss and among adults with underlying diseases. The aim of this article is to provide a comprehensive review of the literature spanning more than a century and to cover all aspects of the disease. The epidemiology, clinical features, potential complications, risk factors, susceptibility, diagnosis, differential diagnoses, investigations currently available, treatment options, and preventive measures are all discussed in detail. Recent crystallographic data on the toxins has provided us with a clearer and more defined approach to studying the disease. Understanding their mode of action has important implications in future treatment and prevention of SSSS and other diseases, and knowledge of their specific site of action may provide a useful tool for physiologists, dermatologists, and pharmacologists.

Download Full-text

Molecular Diagnostics and Biological Safety 2021. COVID-19: Epidemiology, Diagnosis and Prophylaxis: Conference Abstracts

10.36233/978-5-6045286-2-4 ◽

2021 ◽

Keyword(s):

Clinical Features ◽

Molecular Diagnostics ◽

Distress Syndrome ◽

Treatment Options ◽

Educational Institutions ◽

Diagnostic Tools ◽

Post Vaccination ◽

Medical Practitioners ◽

Coronavirus Infection ◽

Post Infectious

The pandemic of the new coronavirus infection has spread to more than 200 countries. To date, over 130 million people have been affected and over 2.8 million have died. COVID-19 infection has a number of specific epidemiological and clinical features. In severe cases of the disease, acute respiratory distress syndrome develops, which is often fatal. The SARS-CoV-2 virus is susceptible to mutations, which alarms the scientific community all over the world. Therefore, scientific research in the field of COVID-19, the search for new diagnostic tools, methods for nonspecific and specific prevention and treatment are central topics today.This collection contains abstracts submitted by leading experts in the field of epidemiology, clinics of infectious diseases, molecular diagnostics, young researchers and medical practitioners. Published materials contain data on the methods of molecular diagnostics of COVID-19, se-quencing of the SARS-CoV-2 genome, epidemiology of new coronavirus infection, immuno-pathogenesis of COVID-19, clinical features of infection and treatment options, as well as the study of post-infectious and post-vaccination immunity and examples of complex measures for nonspecific prevention of COVID-19.The materials of the Congress are of interest to doctors and researchers of all specialties, teachers of secondary and higher educational institutions.

Download Full-text

Postural orthostatic tachycardia syndrome in primary care: diagnosis, treatment and a case of African-American man presenting with POTS

BMJ Case Reports ◽

10.1136/bcr-2019-229824 ◽

2019 ◽

Vol 12 (9) ◽

pp. e229824

Author(s):

Andrew T Del Pozzi ◽

Michael Enechukwu ◽

Svetlana Blitshteyn

Keyword(s):

Heart Rate ◽

Differential Diagnosis ◽

African American ◽

Clinical Features ◽

Orthostatic Intolerance ◽

Treatment Options ◽

Postural Orthostatic Tachycardia Syndrome ◽

Tilt Table Test ◽

Tilt Table ◽

Caucasian Women

Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous autonomic disorder characterised by orthostatic intolerance and a rise in heart rate by at least 30 bpm or an absolute heart rate value of at least 120 bpm within 10 min of standing or during a tilt table test. Overwhelmingly, POTS affects young Caucasian women, which can lead physicians to miss the diagnosis in men or non-white patients. We describe a case of 29-year-old African-American man who developed lightheadedness, generalised weakness, tachycardia and palpitations and was subsequently diagnosed with POTS. We review its clinical features, differential diagnosis, pathophysiology and treatment options. We also emphasise that POTS should be considered as a differential diagnosis in any patient presenting with typical clinical features, who may not be in the usual demographics of the disorder.

Download Full-text

Laparoscopic Total Gastrectomy with Roux-Y Esophagojejunostomy for Chronic Gastric Fistula After Laparoscopic Sleeve Gastrectomy

Obesity Surgery ◽

10.1007/s11695-013-1162-1 ◽

2013 ◽

Vol 24 (3) ◽

pp. 425-429 ◽

Cited By ~ 23

Author(s):

Almog Ben Yaacov ◽

Eran Sadot ◽

Matan Ben David ◽

Nir Wasserberg ◽

Andrei Keidar

Keyword(s):

Sleeve Gastrectomy ◽

Laparoscopic Sleeve Gastrectomy ◽

Total Gastrectomy ◽

Laparoscopic Total Gastrectomy ◽

Gastric Fistula

Download Full-text

Non-Melanoma Skin Cancers: Biological and Clinical Features

International Journal of Molecular Sciences ◽

10.3390/ijms21155394 ◽

2020 ◽

Vol 21 (15) ◽

pp. 5394

Author(s):

Mauro Cives ◽

Francesco Mannavola ◽

Lucia Lospalluti ◽

Maria Chiara Sergi ◽

Gerardo Cazzato ◽

...

Keyword(s):

Cell Carcinoma ◽

Clinical Features ◽

Clinical Presentation ◽

Treatment Options ◽

Biological Evolution ◽

Hedgehog Pathway ◽

Merkel Cell ◽

Innovative Treatment ◽

Skin Cancers ◽

Melanoma Skin

Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. As result of our improved understanding of the biology of non-melanoma skin cancers, innovative treatment options including inhibitors of the Hedgehog pathway and immunotherapeutic agents have been recently investigated against these malignancies, leading to their approval by regulatory authorities. Herein, we review the most relevant biological and clinical features of NMSC, focusing on innovative treatment approaches.

Download Full-text

Desmoid Tumors: Clinical Features and Treatment Options for Advanced Disease

The Oncologist ◽

10.1634/theoncologist.2010-0281 ◽

2011 ◽

Vol 16 (5) ◽

pp. 682-693 ◽

Cited By ~ 123

Author(s):

Bernd Kasper ◽

Philipp Ströbel ◽

Peter Hohenberger

Keyword(s):

Clinical Features ◽

Advanced Disease ◽

Treatment Options ◽

Desmoid Tumors

Download Full-text

Orthodontic Conundrums Part 1: Transposition – an Update on Presentation and Treatment Modalities

Orthodontic Update ◽

10.12968/ortu.2020.13.4.188 ◽

2020 ◽

Vol 13 (4) ◽

pp. 188-198

Author(s):

Naeem I Adam ◽

Adam Jowett ◽

Trevor Hodge

Keyword(s):

Clinical Features ◽

Clinical Relevance ◽

Treatment Options ◽

The Other ◽

Treatment Modalities ◽

Dental Anomalies ◽

Treatment Approaches ◽

Dental Practitioner ◽

General Dental Practitioner ◽

Iatrogenic Harm

This is the first article in a three-part series considering uncommon dental anomalies and treatment approaches. Dental transpositions are rare anomalies which may present to the general dental practitioner or orthodontist. The management of transpositions is dependent on several factors, including the sub-type, severity and the other salient features of the malocclusion. Transposition may either be accepted or orthodontically corrected and the adoption of either approach must be preceded by thorough assessment of the patient. CPD/Clinical Relevance: The presentation and management of transposition is variable. The general dental practitioner must be aware of the clinical features of a developing transposition as certain treatment options are only possible before the transposition is fully established. In addition, the orthodontist must be mindful of the potential for iatrogenic harm if these dental anomalies are managed injudiciously.

Download Full-text