Analysis of clinical manifestations and prognosis of 92 cases with non-Hodgkin’s lymphoma

2008 ◽  
Vol 5 (3) ◽  
pp. 195-199
Author(s):  
Xianlin Duan ◽  
Ming Jiang
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Clinical Manifestations ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

The BCR repertoire comparison, lymphoma typing model and OS predicted model in 5 different pathological lymphomas: T-LBL/ALL, PTCL-NOS, B-MCL, B-FL, and DLBCL.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 8059-8059
Author(s):  
Wenhua Jiang ◽  
Shiyong Zhou ◽  
Jian Li ◽  
Mingyou Gao ◽  
Kuo Zhao ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin’S Lymphoma ◽  
Clinical Manifestations ◽  
Vital Role ◽  
Hodgkin's Lymphoma ◽  
Cell Repertoire ◽  
Clinical Indicators ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Predicted Model

8059 Background: Lymphatic system cancer is characterized by high heterogeneity in histology and clinical manifestations, B-cell antigen receptor (BCR) plays a vital role in anti-tumor immune responses. This study aimed to compare the BCR repertoire and identify some specific immune markers for different pathological lymphomas. Methods: 5 pathological types of non-Hodgkin's lymphoma (T-LBL/ALL, PTCL-NOS, B-MCL, B-FL, DLBCL) were collected, with reactive lymph node (RLN) hyperplasia as control. All patients were tested by high-throughput immunohistochemical sequencing (HTS-IR) to analyze the correlation between B-cell immunohistochemistry and clinical indicators, and constructed new strategy typing and overall survival (OS) predicted models for lymphomas. Results: The BCR repertoire had the highest diversity in RLN, followed by T-LBL/ALL, PTCL-NOS, DLBCL, B-MCL and B-FL. The diversity of BCR repertoire and similarity of B cell antigens were higher in B-MCL and B-FL patients. Similar to RLN, T-LBL/ALL and PTCL-NOS had broad and diverse V-J pairs, and rare in B-MCL, B-FL and DLBCL. RLN patients were with the highest average number of amino acids, followed by T-LBL/ALL, DLBCL, PTCL-NOS, B-MCL and B-FL. The expressed amino acid sequencing of ARDLIALDY, ARRPGSFDY, ARDIAGWGAVAGLLGRAYYGMDV, and ARDGPYGGNSVEYFQH were markedly different among 5 groups. Patients tended to recurrence expressed ASLDSSPSGFC, ARGMTTVTTAPNY, ARVPLYDDQNINDV and AGGVGGYDWGSYYFDY (P = 0.01605, 0.02869, and 0.01569), and prone to metastasis with expressions of ARVKEFYGILTGYDY, AHSIIGSSWYNWFDP and VRDGGWQSNNWLGFDV (P = 0.04259, 0.0450 and 0.0481). For all patients, 18 (7 negative, 11 positive) and 12 (10 negative, 2 positive) IGH V-J pairs were respectively associated with lymphoma recurrence and metastasis. The top 3 most significant pairs were IGHV7-4-1_IGHJ4, IGHV3-53_IGHJ5 and IGHV3-7_IGHJ5 bound up with recurrence (P = 0.0019, 0.0020 and 0.0021), and IGHV3-74_IGHJ1, IGHV1-69_IGHJ3 and IGHV1-2_IGHJ1 related to metastasis (P = 0.0022, 0.010 and 0.019). The accuracy of typing model in training and test sets was 78.125% (25/32) and 60% (6/10), respectively. The OS model can predict long (≥ 24 months) or short ( < 24 months) OS. Conclusions: Our study identified new biomarkers, constructed novel lymphoma typing model and OS predicted model based on B cell repertoire. It provides a comprehensive understanding of immune response, and contributes to the diagnosis and prognosis of non-Hodgkin's lymphoma.

Volume formation of the orbit in hemoblastosis

2021 ◽  
Vol 22 (1) ◽  
pp. 114-117
Author(s):  
M. N. Ponomareva ◽  
◽  
I. N. Pakhirko ◽  
I. A. Arefieva ◽  
E. S. Klimov ◽  
...  
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Clinical Case ◽  
Soft Tissues ◽  
Clinical Manifestations ◽  
Pain Syndrome ◽  
Hodgkin's Lymphoma ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Hematology is the most important branch of practical medicine, thanks to significant advances in the diagnosis and treatment of hemoblastosis. The earlier the timely complex treatment is started, the better the vital prognosis and fewer complications. Aim.To present a clinical case of volumetric orbit formation in a 67-year-old man with hemoblastosis. Materials and methods. A retrospective analysis of the dynamics of the development of clinical manifestations and diagnostics of the volume formation of the orbit in a patient born in 1954 was carried out. Results. The patient suffers from diffuse non-Hodgkin’s lymphoma, unspecified, with lesions of the axillary lymph nodes on both sides, the soft tissues of the chest on the right, and the peritoneum. Chronic pain syndrome. The diagnosis was made in the oncological dispensary, where he was in 28.12.2020. Complaints from the organ of vision appeared on 09.01.2021, but the patient was not examined by an ophthalmologist. The immunohistochemical study of 15.01.2021 confirmed the morphological picture of the lymphoproliferative disease, but the patient did not receive specialized antitumor therapy, and therefore the ophthalmic symptoms continued to increase, vision loss and pain syndrome increased. Regarding the above complaints, the patient went to the emergency room of ophthalmological care. Computed tomography of the brain and orbits was performed in addition to standard ophthalmological examinations. The formation of the left orbit with exophthalmos was diagnosed. Conclusion. This clinical case shows that in male patients, aged 67 years, the ophthalmological manifestations of non-Hodgkin’s lymphoma may be metastasis to the orbit with a gradual increase in the clinical picture (displacement of the eyeball, movement restrictions, exophthalmos), for 2 weeks, while maintaining visual functions (visual acuity 0.7-0.8) and the occurrence of conjunctivitis.

scholarly journals The Relationship Between Clinical Manifestation and Histopatological Result in Non- Hodgkin Lymphoma: RSUD Dr. Soetomo Surabaya

2021 ◽  
Vol 5 (4) ◽  
pp. 134-138
Author(s):  
Glazydia Juwita Rachma ◽  
Ugroseno Yudho Bintoro ◽  
Mia Ratwita Andarsini ◽  
Novira Widajanti
Keyword(s):  
Hodgkin Lymphoma ◽  
Hodgkin’S Lymphoma ◽  
Clinical Manifestations ◽  
Hodgkin's Lymphoma ◽  
Major Public Health Problem ◽  
Non Hodgkin Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Degree Of Malignancy ◽  
The Relationship

Non-Hodgkin's lymphoma is a major public health problem with over 14.1 million people are diagnosed with it (2012). In the same year there were 8.2 million deaths due to cancer. The purpose of this study was to determine the relationship between clinical manifestations and the degree of malignancy based on histopathological features in patients with Non-Hodgkin's Lymphoma. This study used a retrospective analytical method with a cross-sectional approach using the patient's medical record at RSUD Dr. Soetomo, Surabaya who was diagnosed with Non-Hodgkin Lymphoma from 1st January 2015 to 31st December 2017. In this study, there were 139 samples include those criteria, with a greater number of male samples (62.6%) compared to women (37.4%). This study showed that 49.3% of patients with non- Hodgkin's lymphoma in RSUD Dr. Soetomo with clinical manifestations without symptoms actually experience malignancy with a high degree, this showed that clinical manifestations without symptoms are not always associated with a low level of malignancy. Then, based on the Chi Square test results obtained p-value of 0.289 (>0.05), so there was no significant relationship between clinical manifestations and the degree of malignancy. Keywords: lymphoma; manifestation; histopatological

scholarly journals Non-Hodgkin's lymphoma with uncommon clinical manifestations: A case report

2015 ◽  
Vol 10 (3) ◽  
pp. 1686-1688 ◽  
Author(s):  
YU-LONG CAI ◽  
XIAN-ZE XIONG ◽  
JIONG LU ◽  
YI-XIN LIN ◽  
NAN-SHENG CHENG
Keyword(s):  
Case Report ◽  
Hodgkin’S Lymphoma ◽  
Clinical Manifestations ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

scholarly journals Primary non-Hodgkin’s lymphoma of the talus

2019 ◽  
Vol 13 (2) ◽  
pp. 184-188
Author(s):  
Gianfrancesco Marconato ◽  
Joao Luiz Vieira Silva ◽  
Renan Marson Costa ◽  
Márcio Fernando Aparecido de Moura
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Clinical Manifestations ◽  
Hodgkin's Lymphoma ◽  
Daily Activities ◽  
Primary Lymphoma ◽  
Level Of Evidence ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Different Types

Lymphoma is a blood cancer that begins in different types of lymphoid or histiocytic cells in various states of maturity. Primary lymphoma of bone is rare, and clinical manifestations include localized pain and edema. The diagnosis takes into consideration the clinical picture, imaging tests and pathological anatomy. In this article, we present the case of a patient with restricted daily activities and loss of quality of life due to primary non-Hodgkin’s lymphoma of the talus. After chemotherapy, the clinical condition of the patient improved. Level of Evidence V; Expert Opinion.

Antiphospholipid Antibodies: Prevalence, Clinical Significance and Correlation to Cytokine Levels in Acute Myeloid Leukemia and Non-Hodgkin’s Lymphoma

1993 ◽  
Vol 70 (04) ◽  
pp. 568-572 ◽  
Author(s):  
Roberto Stasi ◽  
Elisa Stipa ◽  
Mario Masi ◽  
Felicia Oliva ◽  
Alessandro Sciarra ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Clinical Significance ◽  
Antiphospholipid Antibodies ◽  
Myeloid Leukemia ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Tnf Alpha ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Acute Myeloid

SummaryThis study was designed to explore the prevalence and clinical significance of elevated antiphospholipid antibodies (APA) titres in patients affected by acute myeloid leukemia (AML) and highgrade non-Hodgkin’s lymphoma (NHL). We also analyzed possible correlations with circulating levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and the soluble form of the receptor for interleukin-2 (sIL-2r). Nineteen patients with de novo AML and 14 patients with newly-diagnosed NHL were investigated. Tests for APA included the measurement of anticardiolipin antibodies (ACA) with a solid-phase immunoassay, and the detection of the lupus-like anticoagulant (LA) activity. Five patients with AML (26.3%) and 5 patients with NHL (35.7%) presented elevated APA at diagnosis, as compared to 3 of 174 persons of the control group (p <0.0001). APA titres became normal in all patients responding to treatment, whereas nonresponders retained elevated levels. In addition, 6 patients (4 with AML and 2 with NHL), who had normal APA at diagnosis and were either refractory to treatment or in relapse, subsequently developed LA and/or ACA positivity. At presentation, the mean levels of IgG- and IgM-ACA in patients were not significantly different from Controls, and concordance between ACA and LA results reached just 30%. With regard to the clinical course, we were not able to detect any statistically significant difference between patients with normal and elevated APA. Pretreatment concentrations of IL-6 and TNF-alpha in AML, and sIL-2r in NHL were found significantly elevated compared to Controls (p = 0.003, p = 0.009 and p = 0.024 respectively). In addition, the levels of these cytokines correlated with IgG-ACA at the different times of laboratory investigations. These results demonstrate that APA may have a role as markers of disease activity and progression in some haematological malignancies.

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