scholarly journals The Relationship Between Clinical Manifestation and Histopatological Result in Non- Hodgkin Lymphoma: RSUD Dr. Soetomo Surabaya

2021 ◽  
Vol 5 (4) ◽  
pp. 134-138
Author(s):  
Glazydia Juwita Rachma ◽  
Ugroseno Yudho Bintoro ◽  
Mia Ratwita Andarsini ◽  
Novira Widajanti
Keyword(s):  
Hodgkin Lymphoma ◽  
Hodgkin’S Lymphoma ◽  
Clinical Manifestations ◽  
Hodgkin's Lymphoma ◽  
Major Public Health Problem ◽  
Non Hodgkin Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Degree Of Malignancy ◽  
The Relationship

Non-Hodgkin's lymphoma is a major public health problem with over 14.1 million people are diagnosed with it (2012). In the same year there were 8.2 million deaths due to cancer. The purpose of this study was to determine the relationship between clinical manifestations and the degree of malignancy based on histopathological features in patients with Non-Hodgkin's Lymphoma. This study used a retrospective analytical method with a cross-sectional approach using the patient's medical record at RSUD Dr. Soetomo, Surabaya who was diagnosed with Non-Hodgkin Lymphoma from 1st January 2015 to 31st December 2017. In this study, there were 139 samples include those criteria, with a greater number of male samples (62.6%) compared to women (37.4%). This study showed that 49.3% of patients with non- Hodgkin's lymphoma in RSUD Dr. Soetomo with clinical manifestations without symptoms actually experience malignancy with a high degree, this showed that clinical manifestations without symptoms are not always associated with a low level of malignancy. Then, based on the Chi Square test results obtained p-value of 0.289 (>0.05), so there was no significant relationship between clinical manifestations and the degree of malignancy. Keywords: lymphoma; manifestation; histopatological

Primary gastrointestinal non-Hodgkin’s lymphoma in two Hungarian regions

2009 ◽  
Vol 150 (35) ◽  
pp. 1649-1653
Author(s):  
Balázs Kollár ◽  
Péter Rajnics ◽  
Béla Hunyady ◽  
Erika Zeleznik ◽  
János Jakucs ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Hodgkin Lymphoma ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

A felnőttkori non-Hodgkin-lymphoma előfordulása az elmúlt évtizedekben jelentősen nőtt. A betegcsoport nagyon heterogén, változatos klinikai és morfológiai megjelenéssel. A legjellemzőbb nodalis érintettség mellett gyakoriak az extranodalis formák, amelyek leggyakrabban a gastrointestinalis traktust, a központi idegrendszert és a bőrt érintik. A gastrointestinalis traktus non-Hodgkin-lymphomáinak kezelési stratégiája változott az elmúlt évtizedben, a kemoimmunoterápia háttérbe szorította a korábban jóval gyakrabban végzett sebészeti beavatkozásokat. Módszerek: A szerzők Kaposváron, a Kaposi Mór Oktató Kórházban és Gyulán, a Pándy Kálmán Megyei Kórházban kezelt 48, gastrointestinalis traktust érintő non-Hodgkin-lymphomás betegük adatait mutatják be. A betegek közül 27 nő és 21 férfi, átlagéletkoruk 67,8 év. A leggyakoribb lokalizáció a gyomor ( n = 26), a leggyakoribb szövettani típus diffúz nagy B-sejtes lymphoma (DLBCL) volt. A betegek rizikófaktorait a nemzetközi prognosztikai index (IPI) alapján állapították meg. Negyvenhat beteg kapott kemoimmunoterápiás kezelést, 6 esetben érintett mezős sugárkezelés, 3 esetben Helicobacter pylori -eradikáció, 4 betegnél gyomorreszekció történt. Eredmények: Az összes beteg 68%-ában sikerült komplett, 13%-ában parciális remissziót elérni, 19% nonreszponder volt. A nemzetközi prognosztikai index alapján a betegek többsége az alacsony, illetve magas intermedier rizikócsoportba tartozott (IPI-átlag: 2,68). A tápcsatorna felső szakaszát érintő lymphomás betegek prognózisa volt a legjobb (IPI: 2,0), ugyanakkor a gyomorlymphomás betegeknél volt a legmagasabb a komplett remisszió aránya (73%). Következtetés: Kemoimmunoterápiával a betegek gyógyulási esélyei javultak az elmúlt évtizedben, a gastrointestinalis traktust érintő non-Hodgkin-lymphomák jelentős hányada meggyógyítható. Az IPI a legelfogadottabb mutató a non-Hodgkin-lymphoma prognózisának megítélésére. A komplett remisszióba jutott betegek prognosztikai indexe volt a legalacsonyabb, de az IPI-n kívül egyéb tényezők is befolyásolhatják a kezelésre adott választ.

scholarly journals RESEARCH CHARACTERISTICS HISTOPATHOLOGY AND APPLICATION IMMUNOHISTOCHEMISTRY TO CLASSIFY NON-HODGKIN LYMPHOMA IN 103 MILITARY HOSPITAL

2021 ◽  
Vol 62 (2) ◽  
Author(s):  
Nguyễn Khắc Tuyến ◽  
Trần Ngọc Dũng
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Hodgkin’S Lymphoma ◽  
B Cell Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Military Hospital ◽  
Non Hodgkin Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Response To Chemotherapy ◽  
Non Hodgkin's Lymphoma

Objective: Evaluate the macroscopic and microscopic characteristics of Non-Hodgkin's lymphoma. Application of the manifestation of immune markers to classification Non-Hodgkin's lymphoma. Matherial and Method: The cross-sectional descriptive, retrospective and prospective study of 75 patients diagnosed on histopathology and immunohistochemistry as Non-Hodgkin's lymphoma at Military Medical Hospital 103 from January 2018 to September 2020. Results: The disease occurred in men more than women: 2/1. The average age of diseases is 58.31 ± 17.62. Non-Hodgkin's lymphoma in the lymph node accounts for the highest proportion (57.3%). WF7 accounts for the highest percentage (54.7%). The majority of the disease is in intermediate malignancy with 76%. B-cell Non-Hodgkin's lymphoma accounts for 84%. Diffuse large B-cell lymphoma accounts for the highest rate of 66.67%, of which the GCB type accounts for 32%, the non-GCB accounts 68%. Conclusion: The diagnosis and classification of Non Hodgkin lymphoma helps clinicians predict the response to chemotherapy, extra life, which is indicative of monoclonal antibody therapy

scholarly journals A case report of COVID-19 in a patient with non-Hodgkin’s lymphoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Owrang Eilami ◽  
Max Igor Banks Ferreira Lopes ◽  
Ronaldo Cesar Borges Gryschek ◽  
Kaveh Taghipour
Keyword(s):  
Emergency Department ◽  
Hodgkin’S Lymphoma ◽  
Past History ◽  
Sao Paulo ◽  
Chemotherapeutic Agents ◽  
Hodgkin's Lymphoma ◽  
São Paulo ◽  
Non Hodgkin Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Abstract Background The current literature is scarce as to the outcomes of COVID-19 infection in non-Hodgkin's lymphoma patients and whether immunosuppressive or chemotherapeutic agents can cause worsening of the patients’ condition during COVID-19 infection. Case presentation Our case is a 59-year-old gentleman who presented to the Emergency Department of the Cancer Institute of Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brazil on 10th May 2020 with a worsening dyspnea and chest pain which had started 3 days prior to presentation to the Emergency Department. He had a past history of non-Hodgkin's lymphoma for which he was receiving chemotherapy. Subsequent PCR testing demonstrated that our patient was SARS-CoV-2 positive. Conclusion In this report, we show a patient with non-Hodgkin lymphoma in the middle of chemotherapy, presented a mild clinical course of COVID-19 infection.

scholarly journals MP7: FAMILIES WITH BOTH NON-HODGKIN'S LYMPHOMA (NHL) AND MYELOMA (MM): ANTICIPATION AND MALE TRANSMISSION

2016 ◽  
Vol 64 (3) ◽  
pp. 807.1-807
Author(s):  
PH Wiernik ◽  
JP Dutcher
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Hematologic Malignancies ◽  
Hodgkin's Lymphoma ◽  
Same Sex ◽  
Autosomal Region ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Affected Sib Pairs ◽  
The Relationship ◽  
Sib Pairs

Purpose of StudyTo determine whether genetic rather than environmental factors may be responsible for the occurrence of these neoplasms in families.Methods UsedWe interrogated our registry of >700 pedigrees of families (fams) with multiple hematologic malignancies. We identified 31 fams with both NHL and MM in their pedigrees. In 16 pedigrees a parent and child were affected (12 father-child pairs and 4 mother-child pairs). Fifteen affected sib pairs were identified in the 31 fams, 10 same sex pairs and 5 male-female pairs. Six of the 31 pedigrees had only 1 affected pair. More distant relationships were observed in other fams.Summary of ResultsMale transmission was evident in 25 fams and female transmission was observed in 6. NHL and MM cases had at least 1 unaffected generation (gen) between them in 8 pedigrees, and the diseases occurrred in sequential (13 fams) or the same gen in 10 fams. MM was the diagnosis (dx) in the youngest affected gen in 9 pedigrees, NHL in 13 pedigrees and both occurred in the youngest gen in 9 fams. The median age at dx of 29 NHL patients for whom data were available was 55 yrs (range, 20–99 yrs), and the median age at dx of 26 MM cases was 56 yrs (range, 30–82 yrs). Ten of 26 MM patients were <50 years old at dx. The presence or absence of anticipation could be assessed in 15 of the 31 pedigrees. All 15 displayed anticipation in terms of succeeding gens developing NHL or MM at an earlier age than did the previous gens (median −19 yrs, range −6 to −56 yrs).ConclusionsWe demonstrate anticipation in 15 assessible fams with both NHL and MM, a feature of familial MM that we previoiusly reported (Despande HA, et al: Br J Haematol 1998). More advanced, aggressive disease at dx in the youngest gen is another feature of anticipation, and was observed in 9 of 13 fams in which it could be assessed. Demonstration of anticipation in all 15 evaluable fams suggests a genetic basis for the relationship between these two B-cell disorders. The increase of same sex sib pairs among affected sib pairs implicates a locus on a pseudo-autosomal region of the X chromonsome as potentially responsible for this observation, as we have previously reported for Hodgkin's lymphoma (Horwitz M, Wiernik PH, Am J Hum Genet 1999). Myeloma and non-Hodgkin's lymphoma may have common genetic causation; molecular studies of these fams are planned.

scholarly journals Hubungan Kadar Laktat Dehidrogenase dengan Stadium Limfoma Maligna Non Hodgkin di Rumah Sakit Dr. M. Djamil Padang periode Desember 2009 sampai Maret 2013

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Dian Rahma Kasir ◽  
Irza Wahid ◽  
Hafni Bachtiar
Keyword(s):  
Lactate Dehydrogenase ◽  
Malignant Lymphoma ◽  
Medical Records ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Cross Sectional ◽  
Non Hodgkin Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Using Data

AbstrakAwal abad ke-2l masyarakat Indonesia mengalami transisi epidemiologi penyakit. Perubahan pola penyakit ini dapat dilihat dari peningkatan insiden penyakit kanker sebagai penyebab kematian di Indonesia dalam 10 tahun terakhir, yaitu dari urutan ke-12 menjadi urutan ke-6. Di Indonesia, limfoma non Hodgkin (LNH) menduduki urutan keenam keganansan yang sering terjadi. Berdasarkan penelitian yang dilakukan oleh Olivia Putri Perdana di bagian patologi anatomi Fakultas Kedokteran Universitas Andalas didapatkan data bahwa pada januari 1997-desember 2001 terdapat 70 (81,39%) penderita limfoma maligna non Hodgkin dari keseluruhan penderita limfoma maligna. Penelitian ini bertujuan untuk mengetahui hubungan kadar laktat dehidrogenase (LDH) dengan stadium pada penderita limfoma maligna non Hodgkin. Penelitian ini adalah penelitian analitik dengan pendekatan cross sectional dengan menggunakan data yang bersumber dari rekam medik pasien. Populasi dari penelitian ini adalah data rekam medik seluruh penderita limfoma maligna non hodgkin yang berobat ke RSUP Dr. M. Djamil Padang yaitu 317 data rekam medik, tetapi yang memenuhi syarat untuk menjadi sampel hanya 40 data. Analisis statistik yang digunakan adalah uji T. Hasil uji statistik menunjukkan adanya hubungan kadar laktat dehidrogenase dengan stadium pada penderita limfoma non Hodgkin (P = 0,001). Diketahui nilai laktat dehidrogenase pada stadium III-IV lebih tinggi daripada nilai laktat dehidrogenase pada stadium I-II.Kata kunci: Laktat dehidrogenase, Limfoma maligna non Hodgkin, Stadium AbstractEarly 21th century, Indonesian society in transition epidemiology of the disease. Changing patterns of disease can be seen from the increased incidence of cancer as a cause of death in Indonesia in the last 10 years, ie from 12th to 6th order. In Indonesia, non-Hodgkin's lymphoma (NHL) ranks sixt frequent in all of cancer. Based on research conducted by Olivia Putri Perdana in anatomic pathology at the Faculty of Medicine, University of Andalas that the data obtained during the January 1997 - December 2001 there were 70 (81.39%) patients with non -Hodgkin's malignant lymphoma of the overall malignant lymphoma patients.This study aims to determine the relationship of levels of lactate dehydrogenase (LDH) with stage of non -Hodgkin's malignant lymphoma patients.This research is a cross sectional analytic approach using data derived from patient medical records. The population is the entire medical record malignant non Hodgkin lymphoma patients who went to DR. M. Djamil Padang hospital, they are 317 medical records, but are eligible to be sampled only 40 data. Statistical analysis used is the T test.Statistical test results show that there is relationship between lactate dehydrogenase levels with stage in non -Hodgkin's lymphoma patients (P = 0.001). Known value of lactate dehydrogenase in stage III - IV is higher than the value of lactate dehidrodenase in stage I - II.Keywords: Lactate dehydrogenase, malignant non-Hodgkin's lymphoma, Stage

Role of Granulocyte Colony-Stimulating Factor in Relapsed/Resistant Intermediate and High-Grade Non-Hodgkin's Lymphoma Patients Treated with the E-Shap Regimen

1995 ◽  
Vol 81 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Monica Mangiagalli ◽  
Isabella Miccolis ◽  
Pierfranco Maffé ◽  
Enrico Maria Pogliani ◽  
Gianmarco Corneo
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Response Rate ◽  
Hodgkin's Lymphoma ◽  
High Dose ◽  
High Grade ◽  
Standard Dosage ◽  
Non Hodgkin Lymphoma ◽  
Methyl Prednisolone ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Aims and background The study assessed the role and potential benefit of rhG-CSF in reducing the frequency, duration and severity of neutropenia following cytotoxic chemotherapy according to the E-SHAP protocol and, at the same time in improving the response rate. Methods Twenty patients with resistant/relapsed intermediate or high-grade non-Hodgkin's lymphoma were treated with the E-SHAP regimen (etoposide + methyl prednisolone + high dose cytosine arabinoside and cisplatin), and in 15 of them, we administered rhG-CSF between chemotherapeutic courses. Results The 15 patients who received G-CSF after E-SHAP were neutropenic for a short time and experienced no febrile episodes or infective complications. In contrast, in the group (5 patients) who did not receive G-CSF, the WBC nadir was lower and the number of days with a neutrophil count below 1.0 × 109/L was longer, with a greater risk of inferctious complications. Of the 15 patients, only one had a delay in chemotherapy administration, and the RDI was 95% in the 65% of patients who received G-CSF. Of 5 patients treated with chemotherapy alone, 4 had a delay and the RDI was over 95% in only one patient. We obtained a good overall response rate (70%) in the group who received G-CSF. In the historical group of 5 non-Hodgkin lymphoma patients, we observed only 1 partial response and 4 had progression of disease. Conclusions Administration of G-CSF is associated with an acceleration of neutrophil recovery, indicating its potential to reduce the risk of infection. The use of G-CSF permitted us to administer intensive chemotherapy without delay and according to standard dosage, with an improved response rate.

The BCR repertoire comparison, lymphoma typing model and OS predicted model in 5 different pathological lymphomas: T-LBL/ALL, PTCL-NOS, B-MCL, B-FL, and DLBCL.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 8059-8059
Author(s):  
Wenhua Jiang ◽  
Shiyong Zhou ◽  
Jian Li ◽  
Mingyou Gao ◽  
Kuo Zhao ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin’S Lymphoma ◽  
Clinical Manifestations ◽  
Vital Role ◽  
Hodgkin's Lymphoma ◽  
Cell Repertoire ◽  
Clinical Indicators ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Predicted Model

8059 Background: Lymphatic system cancer is characterized by high heterogeneity in histology and clinical manifestations, B-cell antigen receptor (BCR) plays a vital role in anti-tumor immune responses. This study aimed to compare the BCR repertoire and identify some specific immune markers for different pathological lymphomas. Methods: 5 pathological types of non-Hodgkin's lymphoma (T-LBL/ALL, PTCL-NOS, B-MCL, B-FL, DLBCL) were collected, with reactive lymph node (RLN) hyperplasia as control. All patients were tested by high-throughput immunohistochemical sequencing (HTS-IR) to analyze the correlation between B-cell immunohistochemistry and clinical indicators, and constructed new strategy typing and overall survival (OS) predicted models for lymphomas. Results: The BCR repertoire had the highest diversity in RLN, followed by T-LBL/ALL, PTCL-NOS, DLBCL, B-MCL and B-FL. The diversity of BCR repertoire and similarity of B cell antigens were higher in B-MCL and B-FL patients. Similar to RLN, T-LBL/ALL and PTCL-NOS had broad and diverse V-J pairs, and rare in B-MCL, B-FL and DLBCL. RLN patients were with the highest average number of amino acids, followed by T-LBL/ALL, DLBCL, PTCL-NOS, B-MCL and B-FL. The expressed amino acid sequencing of ARDLIALDY, ARRPGSFDY, ARDIAGWGAVAGLLGRAYYGMDV, and ARDGPYGGNSVEYFQH were markedly different among 5 groups. Patients tended to recurrence expressed ASLDSSPSGFC, ARGMTTVTTAPNY, ARVPLYDDQNINDV and AGGVGGYDWGSYYFDY (P = 0.01605, 0.02869, and 0.01569), and prone to metastasis with expressions of ARVKEFYGILTGYDY, AHSIIGSSWYNWFDP and VRDGGWQSNNWLGFDV (P = 0.04259, 0.0450 and 0.0481). For all patients, 18 (7 negative, 11 positive) and 12 (10 negative, 2 positive) IGH V-J pairs were respectively associated with lymphoma recurrence and metastasis. The top 3 most significant pairs were IGHV7-4-1_IGHJ4, IGHV3-53_IGHJ5 and IGHV3-7_IGHJ5 bound up with recurrence (P = 0.0019, 0.0020 and 0.0021), and IGHV3-74_IGHJ1, IGHV1-69_IGHJ3 and IGHV1-2_IGHJ1 related to metastasis (P = 0.0022, 0.010 and 0.019). The accuracy of typing model in training and test sets was 78.125% (25/32) and 60% (6/10), respectively. The OS model can predict long (≥ 24 months) or short ( < 24 months) OS. Conclusions: Our study identified new biomarkers, constructed novel lymphoma typing model and OS predicted model based on B cell repertoire. It provides a comprehensive understanding of immune response, and contributes to the diagnosis and prognosis of non-Hodgkin's lymphoma.

Volume formation of the orbit in hemoblastosis

2021 ◽  
Vol 22 (1) ◽  
pp. 114-117
Author(s):  
M. N. Ponomareva ◽  
◽  
I. N. Pakhirko ◽  
I. A. Arefieva ◽  
E. S. Klimov ◽  
...  
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Clinical Case ◽  
Soft Tissues ◽  
Clinical Manifestations ◽  
Pain Syndrome ◽  
Hodgkin's Lymphoma ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Hematology is the most important branch of practical medicine, thanks to significant advances in the diagnosis and treatment of hemoblastosis. The earlier the timely complex treatment is started, the better the vital prognosis and fewer complications. Aim.To present a clinical case of volumetric orbit formation in a 67-year-old man with hemoblastosis. Materials and methods. A retrospective analysis of the dynamics of the development of clinical manifestations and diagnostics of the volume formation of the orbit in a patient born in 1954 was carried out. Results. The patient suffers from diffuse non-Hodgkin’s lymphoma, unspecified, with lesions of the axillary lymph nodes on both sides, the soft tissues of the chest on the right, and the peritoneum. Chronic pain syndrome. The diagnosis was made in the oncological dispensary, where he was in 28.12.2020. Complaints from the organ of vision appeared on 09.01.2021, but the patient was not examined by an ophthalmologist. The immunohistochemical study of 15.01.2021 confirmed the morphological picture of the lymphoproliferative disease, but the patient did not receive specialized antitumor therapy, and therefore the ophthalmic symptoms continued to increase, vision loss and pain syndrome increased. Regarding the above complaints, the patient went to the emergency room of ophthalmological care. Computed tomography of the brain and orbits was performed in addition to standard ophthalmological examinations. The formation of the left orbit with exophthalmos was diagnosed. Conclusion. This clinical case shows that in male patients, aged 67 years, the ophthalmological manifestations of non-Hodgkin’s lymphoma may be metastasis to the orbit with a gradual increase in the clinical picture (displacement of the eyeball, movement restrictions, exophthalmos), for 2 weeks, while maintaining visual functions (visual acuity 0.7-0.8) and the occurrence of conjunctivitis.

Sign in / Sign up

Export Citation Format

Share Document