Pregnancy and perinatal outcomes after assisted reproduction: a comparative study

2008 ◽  
Vol 177 (3) ◽  
pp. 233-241 ◽  
Author(s):  
C. Allen ◽  
S. Bowdin ◽  
R. F. Harrison ◽  
A. G. Sutcliffe ◽  
L. Brueton ◽  
...  
Keyword(s):  
Comparative Study ◽  
Assisted Reproduction ◽  
Perinatal Outcomes

scholarly journals Pregnancy and perinatal outcomes after assisted reproduction: a comparative study

2008 ◽  
Vol 178 (1) ◽  
pp. 119-119
Author(s):  
E. S. Sills ◽  
D. J. Walsh ◽  
A. P. H. Walsh
Keyword(s):  
Comparative Study ◽  
Assisted Reproduction ◽  
Perinatal Outcomes

Perinatal outcomes and cost-effectivity of the assisted reproduction pregnancies with advanced age: A retrospective analysis

2016 ◽  
Vol 37 (4) ◽  
pp. 450-453 ◽  
Author(s):  
Nafiye Yilmaz ◽  
Mustafa Kara ◽  
Bugra Coskun ◽  
Metin Kaba ◽  
Selçuk Erkilinc ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Assisted Reproduction ◽  
Perinatal Outcomes ◽  
Advanced Age

scholarly journals Efficacy of normalization of vaginal microbiota after antimicrobial treatment for bacterial vaginosis and bacterial vaginosis in pregnant women (results of the multicenter prospective non-interventional comparative study)

2021 ◽  
Vol 4 (3) ◽  
pp. 192-200
Author(s):  
V.E. Radzinskiy ◽  
◽  
I.B. Manukhin ◽  
I.M. Ordiyants ◽  
V.E. Balan ◽  
...  
Keyword(s):  
Comparative Study ◽  
Bacterial Vaginosis ◽  
Pregnant Women ◽  
Perinatal Outcomes ◽  
Antimicrobial Treatment ◽  
Vulvovaginal Candidiasis ◽  
Vaginal Microbiota ◽  
Vaginal Microflora ◽  
Key Indicator

ABSTRACT Aim: to assess the efficacy and safety of Lactogynal® to normalize vaginal microflora after antimicrobial treatment for bacterial vaginosis (BV) and to prevent recurrences of vulvovaginal candidiasis (VVC) during pregnancy. Patients and Methods: this multicenter prospective non-interventional comparative study included 100 women in the 3rd trimester of pregnancy diagnosed with acute BV (n=50) or acute VVC (n=50). 25 women of each group received standard antimicrobial treatment only. 25 women of each group received Lactogynal® as the second step of antimicrobial treatment. Women were followed up until delivery and discharge. The rate of BV and VVC recurrences before delivery was considered the key indicator of treatment efficacy. In addition, obstetrical and perinatal outcomes, compliance, the type and duration of antimicrobial treatment for BV and VVC were evaluated. Results: in women with BV and VVC who received Lactogynal®, no recurrences during the follow-up were reported (p<0.05). In women who received standard antimicrobial treatment only, the rate of recurrences of BV and VVC was 40% and 28%, respectively. As to the complications of pregnancy, delivery, and the postpartum period, women with BV who received probiotic therapy were less often diagnosed with anemia (p<0.05) while women with VVC who received probiotic therapy were less often diagnosed with the premature rupture of membranes (p<0.05). Conclusions: Lactogynal® is an effective and safe tool to normalize vaginal microflora after antimicrobial treatment for BV and to prevent VVC recurrences during the 3rd trimester of pregnancy. This drug (as a part of complex treatment for BV and VVC) reduces the risk of recurrences and promotes a more favorable pregnancy course until delivery. KEYWORDS: lactobacilli, bacterial vaginosis, vulvovaginal candidiasis, pregnancy, vaginal microflora. FOR CITATION: Radzinskiy V.E., Manukhin I.B., Ordiyants I.M. et al. Efficacy of normalization of vaginal microbiota after antimicrobial treatment for bacterial vaginosis and bacterial vaginosis in pregnant women (results of the multicenter prospective non-interventional comparative study). Russian Journal of Woman and Child Health. 2021;4(3):192–200 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-192-200.

scholarly journals Placental changes and perinatal outcomes among women with preeclampsia/eclampsia and normotensive women: A comparative study

2021 ◽  
Vol 6 (1) ◽  
pp. 41
Author(s):  
AdebunmiOyeladun Olarinoye ◽  
OlalekeOluwasegun Folaranmi ◽  
BabakayodeAbel Olagbaye ◽  
JohnKola Olarinoye ◽  
KikeTemilola Adesina ◽  
...  
Keyword(s):  
Comparative Study ◽  
Perinatal Outcomes

Outcome of monochorionic-biamniotic twins conceived by assisted reproduction: a population-based study

2016 ◽  
Vol 44 (8) ◽  
Author(s):  
Andreja Trojner Bregar ◽  
Isaac Blickstein ◽  
Ivan Verdenik ◽  
Miha Lucovnik ◽  
Natasa Tul
Keyword(s):  
Assisted Reproduction ◽  
Perinatal Outcomes ◽  
Population Based ◽  
Monochorionic Twins ◽  
Population Based Study ◽  
Maternal Characteristics ◽  
Assisted Reproduction Technology ◽  
Increased Risk ◽  
Adverse Perinatal Outcomes ◽  
Twin Pregnancies

AbstractObjecive:To evaluate the perinatal outcome of monochorionic-diamniotic twins conceived by assisted reproduction technology (ART).Methods:We compared data from a national population-based perinatal registry on perinatal outcomes of monochorionic-diamniotic twins conceived by ART with their dichorionic counterparts and with spontaneous monochorionic-diamniotic twins. We compared maternal characteristics, pregnancy complications and perinatal outcomes.Results:Monochorionic-diamniotic twin pregnancies (n=45) comprised 5.5% of all ART twins, and 9.3% of all monochorionic twins in this dataset. ART does not appear to increase the already high risk of monochorionicity compared to spontaneous conception, with the latter having an increased incidence for birth weight <1500 g [odds ratio (OD) 2.6, 95% confidence interval (CI) 1.2–5.4].Conclusion:Our results disagree with hospital-based data and suggest that monochorionic-diamniotic twins following ART are not at increased risk of adverse perinatal outcomes compared to spontaneous monochorionic-diamniotic twins as well as to dichorionc twins conceived by ART.

scholarly journals Congenital anomalies and other perinatal outcomes in ICSI vs. naturally conceived pregnancies: a comparative study

2009 ◽  
Vol 26 (7) ◽  
pp. 377-381 ◽  
Author(s):  
Suliman Al-Fifi ◽  
Ali Al-Binali ◽  
Mesfer Al-Shahrani ◽  
Hajra Shafiq ◽  
Mohamad Bahar ◽  
...  
Keyword(s):  
Comparative Study ◽  
Congenital Anomalies ◽  
Perinatal Outcomes

scholarly journals Birthweight and other perinatal outcomes of singletons conceived after assisted reproduction compared to natural conceived singletons in couples with unexplained subfertility: follow-up of two randomized clinical trials

2020 ◽  
Author(s):  
J A Wessel ◽  
F Mol ◽  
N A Danhof ◽  
A J Bensdorp ◽  
R I Tjon-Kon Fat ◽  
...  
Keyword(s):  
Clinical Trials ◽  
The Netherlands ◽  
Assisted Reproduction ◽  
Ovarian Stimulation ◽  
Randomized Clinical Trials ◽  
Perinatal Outcomes ◽  
Laboratory Procedures ◽  
The Mean ◽  
Natural Conception

Abstract STUDY QUESTION Does assisted reproduction, such as ovarian stimulation and/or laboratory procedures, have impact on perinatal outcomes of singleton live births compared to natural conception in couples with unexplained subfertility? SUMMARY ANSWER Compared to natural conception, singletons born after intrauterine insemination with ovarian stimulation (IUI-OS) had a lower birthweight, while singletons born after IVF had comparable birthweights, in couples with unexplained subfertility. WHAT IS KNOWN ALREADY Singletons conceived by assisted reproduction have different perinatal outcomes such as low birthweight and a higher risk of premature birth than naturally conceived singletons. This might be due to the assisted reproduction, such as laboratory procedures or the ovarian stimulation, or to an intrinsic factor in couples with subfertility. STUDY DESIGN, SIZE, DURATION We performed a prospective cohort study using the follow-up data of two randomized clinical trials performed in couples with unexplained subfertility. We evaluated perinatal outcomes of 472 live birth singletons conceived after assisted reproduction or after natural conception within the time horizon of the studies. PARTICIPANTS/MATERIALS, SETTING, METHODS To assess the possible impact of ovarian stimulation we compared the singletons conceived after IUI with FSH or clomiphene citrate (CC) and IVF in a modified natural cycle (IVF-MNC) or standard IVF with single embryo transfer (IVF-SET) to naturally conceived singletons in the same cohorts. To further look into the possible effect of the laboratory procedures, we put both IUI and IVF groups together into IUI-OS and IVF and compared both to singletons born after natural conception. We only included singletons conceived after fresh embryo transfers. The main outcome was birthweight presented as absolute weight in grams and gestational age- and gender-adjusted percentiles. We calculated differences in birthweight using regression analyses adjusted for maternal age, BMI, smoking, parity, duration of subfertility and child gender. MAIN RESULTS AND THE ROLE OF CHANCE In total, there were 472 live birth singletons. Of the 472 singleton pregnancies, 209 were conceived after IUI-OS (136 with FSH and 73 with CC as ovarian stimulation), 138 after IVF (50 after IVF-MNC and 88 after IVF-SET) and 125 were conceived naturally. Singletons conceived following IUI-FSH and IUI-CC both had lower birthweights compared to naturally conceived singletons (adjusted difference IUI-FSH −156.3 g, 95% CI −287.9 to −24.7; IUI-CC −160.3 g, 95% CI −316.7 to −3.8). When we compared IVF-MNC and IVF-SET to naturally conceived singletons, no significant difference was found (adjusted difference IVF-MNC 75.8 g, 95% CI −102.0 to 253.7; IVF-SET −10.6 g, 95% CI −159.2 to 138.1). The mean birthweight percentile was only significantly lower in the IUI-FSH group (−7.0 percentile, 95% CI −13.9 to −0.2). The IUI-CC and IVF-SET group had a lower mean percentile and the IVF-MNC group a higher mean percentile, but these groups were not significant different compared to the naturally conceived group (IUI-CC −5.1 percentile, 95% CI −13.3 to 3.0; IVF-MNC 4.4 percentile, 95% CI −4.9 to 13.6; IVF-SET −1.3 percentile, 95% CI −9.1 to 6.4). Looking at the laboratory process that took place, singletons conceived following IUI-OS had lower birthweights than naturally conceived singletons (adjusted difference −157.7 g, 95% CI −277.4 to −38.0). The IVF group had comparable birthweights with the naturally conceived group (adjusted difference 20.9 g, 95% CI −110.8 to 152.6). The mean birthweight percentile was significantly lower in the IUI-OS group compared to the natural group (−6.4 percentile, 95% CI −12.6 to −0.1). The IVF group was comparable (0.7 percentile, 95% CI −6.1 to 7.6). LIMITATIONS, REASONS FOR CAUTION The results are limited by the number of cases. The data were collected prospectively alongside the randomized controlled trials, but analyzed as treated. WIDER IMPLICATIONS OF THE FINDINGS Our data suggest IUI in a stimulated cycle may have a negative impact on the birthweight of the child and possibly on pre-eclampsia. Further research should look into the effect of different methods of ovarian stimulation on placenta pathology and pre-eclampsia in couples with unexplained subfertility using naturally conceived singletons in the unexplained population as a reference. STUDY FUNDING/COMPETING INTEREST(S) Both initial trials were supported by a grant from ZonMW, the Dutch Organization for Health Research and Development (INeS 120620027, SUPER 80-83600-98-10192). The INeS study also had a grant from Zorgverzekeraars Nederland, the Dutch association of healthcare insurers (09-003). B.W.J.M. is supported by an NHMRC investigator Grant (GNT1176437) and reports consultancy for ObsEva, Merck Merck KGaA, Guerbet and iGenomix, outside the submitted work. A.H. reports grants from Ferring Pharmaceutical company (the Netherlands), outside the submitted work. F.J.M.B. receives monetary compensation as a member of the external advisory board for Merck Serono (the Netherlands), Ferring Pharmaceutics BV (the Netherlands) and Gedeon Richter (Belgium), he receives personal fees from educational activities for Ferring BV (the Netherlands) and for advisory and consultancy work for Roche and he receives research support grants from Merck Serono and Ferring Pharmaceutics BV, outside the submitted work. The remaining authors have nothing to disclose. TRIAL REGISTRATION NUMBER INeS study Trial NL915 (NTR939); SUPER Trial NL3895 (NTR4057)

scholarly journals Comparative study of perinatal outcomes between pregnant women with gestational diabetes mellitus diagnosed by the new IADPSG and the old ADA criteria

2015 ◽  
Vol 7 (S1) ◽  
Author(s):  
Phelipe Guimarães de Ornellas ◽  
Luana Verztman Bagdadi ◽  
Zuliana Bonde Almeida ◽  
Priscila de Almeida Lago ◽  
Ana Luíza Campanholo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Comparative Study ◽  
Pregnant Women ◽  
Perinatal Outcomes
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