The Role of Antisense Oligonucleotide Therapy in Patients with Familial Hypercholesterolemia: Risks, Benefits, and Management Recommendations

2014 ◽  
Vol 17 (1) ◽  
Author(s):  
Anandita Agarwala ◽  
Peter Jones ◽  
Vijay Nambi
Keyword(s):  
Familial Hypercholesterolemia ◽  
Antisense Oligonucleotide ◽  
Antisense Oligonucleotide Therapy ◽  
Management Recommendations

Long non-coding RNAs–towards precision medicine in diabetic kidney disease?

2016 ◽  
Vol 130 (18) ◽  
pp. 1599-1602 ◽  
Author(s):  
Usha Panchapakesan ◽  
Carol Pollock
Keyword(s):  
Kidney Disease ◽  
Precision Medicine ◽  
Antisense Oligonucleotide ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
Non Coding Rnas ◽  
Antisense Oligonucleotide Therapy ◽  
Targeted Medicine

In this review we summarize the role of long non-coding RNAs (LNCRNAs) in diabetic kidney disease (DKD) and the existing antisense oligonucleotide therapy that may provide precise and targeted medicine to treat DKD in this postgenomic era.

Antisense-Oligonucleotide Therapy

1996 ◽  
Vol 334 (5) ◽  
pp. 316-318 ◽  
Author(s):  
Frederick K. Askari ◽  
W. Michael McDonnell
Keyword(s):  
Antisense Oligonucleotide ◽  
Antisense Oligonucleotide Therapy

The role of mipomersen therapy in the treatment of familial hypercholesterolemia

2012 ◽  
Vol 2 (10) ◽  
pp. 1033-1037 ◽  
Author(s):  
Roda Plakogiannis ◽  
Lisa Cioce ◽  
Edward A Fisher ◽  
James A Underberg
Keyword(s):  
Familial Hypercholesterolemia

scholarly journals LOX-1 Inhibition in ApoE KO Mice Using a Schizophyllan-based Antisense Oligonucleotide Therapy

2012 ◽  
Vol 1 ◽  
pp. e58 ◽  
Author(s):  
Francesca Amati ◽  
Laura Diano ◽  
Lucia Vecchione ◽  
Giuseppe Danilo Norata ◽  
Yoshikazu Koyama ◽  
...  
Keyword(s):  
Antisense Oligonucleotide ◽  
Apoe Ko Mice ◽  
Antisense Oligonucleotide Therapy ◽  
Apoe Ko

The Management of Archeological Sites as Tourism Resources

2020 ◽  
pp. 821-838
Author(s):  
Nuria Huete-Alcocer ◽  
María Pilar Martínez-Ruiz ◽  
Víctor Raúl López-Ruiz ◽  
Alicia Izquierdo-Yusta
Keyword(s):  
Economic Development ◽  
Information Sources ◽  
Cultural Tourism ◽  
Tourism Management ◽  
Socio Economic Development ◽  
Tourism Resource ◽  
Tourism Resources ◽  
Management Recommendations ◽  
Role Of Information

This article aims to study the potential of archeology as a tourism resource in the field of cultural tourism, given that good tourism management of archeological sites can attract a larger number of visitors and contribute to the socio-economic development of the areas involved. Specifically, it will examine the role of information sources in the management of such sites, focusing on the case of Segóbriga Archeological Park, Cuenca, Spain. Based on the analysis of the results obtained from surveys of tourists to this destination, this article makes a series of management recommendations concerning the importance of disseminating and promoting this type of tourism resource through various information sources.

ROLE OF INNATE AND ADAPTIVE IMMUNITY ON ATHEROSCLEROSIS IN SUBJECTS WITH FAMILIAL HYPERCHOLESTEROLEMIA

2019 ◽  
Vol 73 (9) ◽  
pp. 1867
Author(s):  
Maria Cristina Izar ◽  
Waleria Fonzar ◽  
Francisco Fonseca ◽  
Henrique Fonseca ◽  
Tuany P. Silva ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Adaptive Immunity ◽  
Innate And Adaptive Immunity

Suppression of the glutamate receptor delta 2 subunit produces a specific impairment in cerebellar long-term depression

1996 ◽  
Vol 76 (5) ◽  
pp. 3578-3583 ◽  
Author(s):  
A. Jeromin ◽  
R. L. Huganir ◽  
D. J. Linden
Keyword(s):  
Glutamate Receptor ◽  
Antisense Oligonucleotide ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate Receptor ◽  
Calcium Influx ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Flow Through

1. The role of the glutamate receptor subunit delta 2 in the induction of cerebellar long-term depression (LTD) was investigated by application of antisense oligonucleotides. The delta 2 subunit is selectively localized to Purkinje cells (PCs), with the highest levels being in the PC dendritic spines, where parallel fibers are received and where cerebellar LTD is expressed. 2. Immunocytochemical analysis of calbindin-positive PCs revealed that both the dendritic and somatic expression of delta 2 was reduced in antisense-but not in sense-treated cultures. An antisense oligonucleotide directed against the related subunit delta 1 did not affect the expression of delta 2 in PCs. 3. Cerebellar LTD may be reliably induced in a preparation of cultured embryonic cerebellar neurons from the mouse when parallel and climbing fiber stimulation are replaced by brief glutamate pulses and strong, direct depolarization of the PC, respectively. Application of an antisense oligonucleotide directed against delta 2 completely blocked the induction of LTD produced by glutamate/ depolarization conjunctive stimulation. A delta 2 sense oligonucleotide or an antisense oligonucleotide directed against the related delta 1 subunit had no effect. 4. The effect of the delta 2 antisense oligonucleotide was not related to attenuation of calcium influx via voltage-gated channels or calcium mobilization via metabotropic glutamate receptors, as assessed with fura-2 microfluorimetry. Current flow through alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-receptor-associated ion channels also appeared unaltered. All three of these processes have previously been shown to be required for cerebellar LTD induction. The observation that delta 2 is involved in a metabotropic-glutamate-receptor-independent signaling pathway that is required for LTD induction supports the view that delta 2 participates in the formation of a novel postsynaptic receptor complex.

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