Gene-Environment Interactions for Cardiovascular Disease

2021 ◽  
Vol 23 (12) ◽  
Author(s):  
Jaana A. Hartiala ◽  
James R. Hilser ◽  
Subarna Biswas ◽  
Aldons J. Lusis ◽  
Hooman Allayee
Keyword(s):  
Cardiovascular Disease ◽  
Gene Environment

Molecular Analysis of Cardiovascular Disease: Some Delay due to Gene-Environment Interactions

2004 ◽  
Vol 4 (03) ◽  
pp. 265-270
Author(s):  
Eric J. Sijbrands ◽  
Geesje Dallinga-Thie ◽  
Janneke G Langendonk
Keyword(s):  
Cardiovascular Disease ◽  
Molecular Analysis ◽  
Gene Environment

scholarly journals Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?

2021 ◽  
Vol 22 (8) ◽  
pp. 4182
Author(s):  
Michal Vrablik ◽  
Dana Dlouha ◽  
Veronika Todorovova ◽  
Denes Stefler ◽  
Jaroslav A. Hubacek
Keyword(s):  
Cardiovascular Disease ◽  
Risk Prediction ◽  
Association Studies ◽  
Risk Scores ◽  
Genome Wide Association Studies ◽  
Cvd Risk ◽  
Mortality And Morbidity ◽  
New Genes ◽  
Gene Environment ◽  
Genome Wide

Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this disease remains a major cause of mortality and morbidity. Recent progress over the last two decades in the field of molecular genetics, especially with new tools such as genome-wide association studies, has helped to identify new genes and their variants, which can be used for calculations of risk, prediction of treatment efficacy, or detection of subjects prone to drug side effects. Although the use of genetic risk scores further improves CVD prediction, the significance is not unambiguous, and some subjects at risk remain undetected. Further research directions should focus on the “second level” of genetic information, namely, regulatory molecules (miRNAs) and epigenetic changes, predominantly DNA methylation and gene-environment interactions.

scholarly journals HLA and Cardiovascular Disease : Additional Comments : SYMPOSIUM ON GENE-ENVIRONMENT INTERACTION IN CARDIOVASCULAR DISEASES

1978 ◽  
Vol 42 (10) ◽  
pp. 1196-1199 ◽  
Author(s):  
SETSUYA NAITO ◽  
KIKUO ARAKAWA ◽  
HISASHI KANAYA ◽  
HISATAKA DOI ◽  
YASUSHI SASAKI ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment

scholarly journals MTHFR gene polymorphism, homocysteine and cardiovascular disease

2001 ◽  
Vol 4 (2b) ◽  
pp. 493-497 ◽  
Author(s):  
Claudio Cortese ◽  
Corradino Motti
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Vitamin B12 ◽  
Mthfr C677t ◽  
Environment Interaction ◽  
Mthfr Polymorphism ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Mthfr Gene Polymorphism ◽  
Transsulfuration Pathway

AbstractHomocysteine is an emerging new risk factor for cardiovascular disease. It is a thiol compound derived from methionine and involved in two main metabolic pathways: the cycle of activated methyl groups, requiring folate and vitamin B12 as cofactors, and the transsulfuration pathway to cystathionine and cysteine requiring vitamin B6 as cofactor. The homocysteine metabolism represents an interesting model of gene-environment interaction. Elevations in homocysteine may be caused by genetic defects in enzymes involved in its metabolism or by deficiencies in cofactor levels. A common polymorphism in the gene coding for the 5, 10-methylene tetrahydrofolate reductase (MTHFR) (C677T, Ala → Val) is associated with a decreased activity of the enzyme due to thermolability. In case of homozygosity for the Val allele, a relative deficiency in the remethylation process of homocysteine into methionine leads to a mild-to-moderate hyperhomocysteinemia, a condition recognized as an independent risk factor for atherosclerosis. The genetic influence of the MTHFR polymorphism on homocysteine levels is attenuated in females in premenopausal age and is not significant in subjects who exhibit serum levels of folate and/or vitamin B12 above the 50th percentile of distribution in the general population. The prevalence of the Val/Val genotype varies among different ethnic groups. It is very low in African populations, whereas in Europe and North America it ranges between 5% and 15%. In Italy an even higher prevalence has been reported in some regions. The question whether the MTHFR polymorphism might be per se an independent contributor to cardiovascular risk is debated. The interaction between this or other genetic factors and environmental/nutritional conditions (i.e. intake of vitamins such as folate) is a key determinant for homocysteine concentrations in healthy conditions as well as in some disease (i.e. in renal disorders). Another example of gene/environment interaction in the field of atherosclerosis is given by the apolipoprotein E polymorphism and its influence in response to diet. The presence of a high prevalence of risk-related allelic variants of such candidate genes within a certain population could serve to locally reinforce the recommendations concerning nutrient intake.

scholarly journals Gene-environment interactions in cardiovascular disease

2011 ◽  
Vol 11 (4) ◽  
pp. 472-478 ◽  
Author(s):  
Elena Flowers ◽  
Erika Sivarajan Froelicher ◽  
Bradley E Aouizerat
Keyword(s):  
Cardiovascular Disease ◽  
Gene Environment

scholarly journals Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

2016 ◽  
Vol 9 (3) ◽  
pp. 291-313 ◽  
Author(s):  
Jane F. Ferguson ◽  
Hooman Allayee ◽  
Robert E. Gerszten ◽  
Folami Ideraabdullah ◽  
Penny M. Kris-Etherton ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Disease Research ◽  
Gene Environment ◽  
New Directions ◽  
Prevention And Treatment
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