The Role of Oral Contraception on Bladder Symptoms

2017 ◽  
Vol 12 (4) ◽  
pp. 361-365
Author(s):  
Lauren N. Wood ◽  
Tamara Grisales
Keyword(s):  
Oral Contraception ◽  
Bladder Symptoms

scholarly journals Involvement of 5-HT3 receptors in pudendal inhibition of bladder overactivity in cats

2013 ◽  
Vol 305 (5) ◽  
pp. F663-F671 ◽  
Author(s):  
Zeyad Schwen ◽  
Yosuke Matsuta ◽  
Bing Shen ◽  
Jicheng Wang ◽  
James R. Roppolo ◽  
...  
Keyword(s):  
High Intensity ◽  
Bladder Capacity ◽  
Saline Control ◽  
Low Intensity ◽  
Afferent Nerves ◽  
Normal Bladder ◽  
Pudendal Neuromodulation ◽  
Bladder Symptoms ◽  
Bladder Activity

In the present study, the role of 5-HT3 receptors in pudendal neuromodulation of bladder activity and its interaction with opioid receptors were investigated in anesthetized cats. The bladder was distended with either saline to induce normal bladder activity or with 0.25% acetic acid (AA) to induce bladder overactivity. Pudendal afferent nerves were activated by 5-Hz stimulation at multiples of the threshold (T) intensity for the induction of anal twitching. AA irritation significantly reduced bladder capacity to 16.5 ± 3.3% of saline control capacity, whereas pudendal nerve stimulation (PNS) at 1.5–2 and 3–4 T restored the capacity to 82.0 ± 12% ( P = 0.0001) and 98.6 ± 15% ( P < 0.0001), respectively. Cumulative doses (1–3 mg/kg iv) of ondansetron, a 5-HT3 receptor antagonist, eliminated low-intensity (1.5–2 T) PNS inhibition and reduced high-intensity (3–4 T) PNS inhibition of bladder overactivity. During saline distention, PNS at 1.5–2 and 3–4 T significantly increased bladder capacity to 173.2 ± 26.4% ( P = 0.036) and 193.2 ± 22.5% ( P = 0.008), respectively, of saline control capacity, but ondansetron (0.003–3 mg/kg iv) did not alter PNS inhibition. Ondansetron (0.1–3 mg/kg) also significantly ( P < 0.05) increased control bladder capacity (50–200%) during either AA irritation or saline distention. In both conditions, the effects of low- and high-intensity PNS were not significantly different. After ondansetron (3 mg/kg) treatment, naloxone (1 mg/kg iv) significantly ( P < 0.05) decreased control bladder capacity (40–70%) during either AA irritation or saline distention but failed to affect PNS inhibition. This study revealed that activation of 5-HT3 receptors has a role in PNS inhibition of bladder overactivity. It also indicated that 5-HT3 receptor antagonists might be useful for the treatment of overactive bladder symptoms.

scholarly journals Role of Trospium chloride and tamsulosin therapy for treating patients with symptoms of over-active bladder related to benign prostatic enlargement

2020 ◽  
Vol 11 (1) ◽  
pp. 650-656
Author(s):  
Falah Mahdi Ali ◽  
Hayder Mahdi Alaridy ◽  
Ahmed Ali Obaid
Keyword(s):  
Teaching Hospitals ◽  
Benign Prostatic Enlargement ◽  
Trospium Chloride ◽  
Prostate Hyperplasia ◽  
Overactive Urinary Bladder ◽  
Prostatic Enlargement ◽  
Bladder Symptoms ◽  
Benign Prostate ◽  
Over Active Bladder

To assess the benefit and safety of composite therapy (Tamsulosin and Trospium drugs) in treating benign prostatic enlargement complain, mainly overactive urinary bladder symptoms. OBJECTIVE: The study has been designed to estimate the benefit and safety of Trospium and Tamsulosin in processing of symptoms of excessive bladder and benign prostate hyperplasia (BPH). Patients and Methods: Prospective clinical trial study conducted at Al-Diwaniya teaching hospitals and private clinics from march 2016 to march 2017, to patients BPH and bothersome symptoms. 60 patients were treated with Tamsulocin and 60 patients were treated by Tamsulocin and Trospium. RESULTS: Median scores of IPSS, OABSS, and QOL proved no big difference between two study sets before staring treatment (P = 0.544), (P = 0.287) , (P = 0.668) consecutively. After one month, both treatments led to a big reduction in IPSS, OABSS median score; (P < 0.001), (P < 0.001). Following three months, both treatments resulted in significant reduction in IPSS (P < 0.001), OABSS (P < 0.001), QOL result, (P < 0.001) consecutively. Conclusion: These results suggest which treatment with Trospium and tamsulosin therapy provides benefit for men with natural - Syndrome of the acute urinary tract and benign enlarged prostate.

Role of urinary cations in the aetiology of bladder symptoms and interstitial cystitis

2014 ◽  
Vol 114 (2) ◽  
pp. 286-293 ◽  
Author(s):  
C. Lowell Parsons ◽  
Timothy Shaw ◽  
Zoltan Berecz ◽  
Yongxuan Su ◽  
Paul Zupkas ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Bladder Symptoms

scholarly journals Neuromodulation for functional bladder disorders in patients with multiple sclerosis

2019 ◽  
Vol 26 (11) ◽  
pp. 1274-1280 ◽  
Author(s):  
Mohammad Sajjad Rahnama’i
Keyword(s):  
Multiple Sclerosis ◽  
Nervous System ◽  
Nerve Stimulation ◽  
Tibial Nerve ◽  
Disease Onset ◽  
Tibial Nerve Stimulation ◽  
Urological Symptoms ◽  
Bladder Symptoms ◽  
Bladder Disorders

The function of the lower urinary tract is mainly storage and voiding of urine, which is coordinated by the nervous system. Various diseases of the nervous system may cause neuro-urological symptoms. Neuro-urological symptoms depend on the localization of the disease and the extension of the neurological lesion. About 80% of multiple sclerosis (MS) patients have neuro-urological symptoms within 10 years after diagnosis. In addition, 10% of MS patients may even present with voiding dysfunction at disease onset. In this review, different types of neuromodulation are discussed. The available studies suggest that sacral neuromodulation (SNM) and percutaneous tibial nerve stimulation (PTNS) may be helpful in the neuromodulation of MS-related overactive bladder symptoms. These techniques may not only decrease the severity of symptoms but also significantly improve the quality of life of affected patients. Exploring the role of implantable tibial nerve stimulation devices in patients with MS could open new doors in the management of urgency and urgency incontinence in this patient group.

Role of Oral Contraception in Congenital Malformations of Offspring

1978 ◽  
Vol 7 (4) ◽  
pp. 309-317 ◽  
Author(s):  
MICHAEL B BRACKEN ◽  
THEODORE R HOLFORD ◽  
COLIN WHITE ◽  
JENNIFER L KELSEY
Keyword(s):  
Congenital Malformations ◽  
Oral Contraception

scholarly journals Role of Family History in Identifying Women With Thrombophilia and Higher Risk of Venous Thromboembolism During Oral Contraception

2003 ◽  
Vol 163 (9) ◽  
pp. 1105 ◽  
Author(s):  
Benilde Cosmi ◽  
Cristina Legnani ◽  
Francesco Bernardi ◽  
Sergio Coccheri ◽  
Gualtiero Palareti
Keyword(s):  
Venous Thromboembolism ◽  
Family History ◽  
Oral Contraception

scholarly journals Endocrinology of women sexual health

2013 ◽  
Vol 62 (5) ◽  
pp. 75-84
Author(s):  
Anna Igorevna Fedorova
Keyword(s):  
Sexual Health ◽  
Female Sexuality ◽  
Preventive Measures ◽  
Oral Contraception ◽  
Endocrine Disorders ◽  
Sexual Dysfunctions ◽  
Different Ages ◽  
Endocrine Factors

The role of endocrine factors in general maintenance of female sexuality in different ages, sexual dysfunctions associated with endocrine disorders, their treatment and preventive measures are considered in the article. The attention was also concentrated to the effects of oral contraception and therapy with oestrogen and testosteron for women sexuality.

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