VA’s National PTSD Brain Bank: a National Resource for Research

2017 ◽  
Vol 19 (10) ◽  
Author(s):  
Matthew J. Friedman ◽  
◽  
Bertrand R. Huber ◽  
Christopher B. Brady ◽  
Robert J. Ursano ◽  
...  
Keyword(s):  
1999 ◽  
Author(s):  
M. Yvonne Jackson ◽  
Margaret C. Graves

2018 ◽  
pp. 91-110
Author(s):  
Tatiana Kochanova

Тhe subject of this study is the young Republic of South Sudan (RSS), the “young” – both in terms of the age of an independent state, and in terms of its demographic potential. RSS, as a member of the United Nations and as a sovereign state, appeared on the world map in 2011, but, possessing super-rich natural resources, has not yet gained sustainable development, moreover, it fell into a deep military-political crisis. Like most countries of the African continent, South Sudan had real demographic capacity, but the authorities were unable to extract any “demographic dividends” from the truly main national resource for the development of the country’s economy, moreover, the number of refugees of young working age is constantly growing. Through the example of South Sudan, which so hard achieved separation of the South from the North and failed to take advantage of the conquered democratic values, the article explores the understudied problem of modification of the consciousness of the younger generation, dictated both by the specifics of the deep historical and cultural tradition of the South Sudanese nationalities and by new trends in global evolutionary processes. Studying the stories from the lives of multi-member families affected during the military-political conflict in the RSS, the author, based on the facts, strongly criticizes the ineffective, even often vicious, youth policy of the South Sudanese government. On the other hand, analyzing the origins, nature, basic traditional moral and sociocultural aspects of child employment in the region, the researcher finds a reasoned explanation of the cause for such a policy of universal child mobilization and tries to define this phenomenon that has not been studied in the scientific literature before. Summarizing the study of the causes of a humanitarian catastrophe in the RSS, the author, in addition to generally accepted factors that influenced the current situation (such as: the intervention of major world financial players in the affairs of a sovereign state, national discord, the struggle for power and resources), also highlights the subjective and not always correct work of the world information agencies and other mass media and, of course, the incompetent state policy of the leadership of the RSS in the Youth Field. Relying on the positive events of the past few months to resolve the conflict in the RSS, the author is still trying to predict in the foreseeable future the time for growth and development of the Republic of South Sudan, with the proviso that it can happen only in case of the inclusion of restraining leverage and expansion of the range of priorities of the main national resource – the youth.


2021 ◽  
Vol 141 (3) ◽  
pp. 399-413 ◽  
Author(s):  
R. A. Hickman ◽  
P. L. Faust ◽  
M. K. Rosenblum ◽  
K. Marder ◽  
M. F. Mehler ◽  
...  

AbstractNeuropathologic hallmarks of Huntington Disease (HD) include the progressive neurodegeneration of the striatum and the presence of Huntingtin (HTT) aggregates that result from abnormal polyQ expansion of the HTT gene. Whether the pathogenic trinucleotide repeat expansion of the HTT gene causes neurodevelopmental abnormalities has garnered attention in both murine and human studies; however, documentation of discrete malformations in autopsy brains of HD individuals has yet to be described. We retrospectively searched the New York Brain Bank (discovery cohort) and an independent cohort (validation cohort) to determine whether developmental malformations are more frequently detected in HD versus non-HD brains and to document their neuropathologic features. One-hundred and thirty HD and 1600 non-HD whole brains were included in the discovery cohort and 720 HD and 1989 non-HD half brains were assessed in the validation cohort. Cases with developmental malformations were found at 6.4–8.2 times greater frequency in HD than in non-HD brains (discovery cohort: OR 8.68, 95% CI 3.48–21.63, P=4.8 × 10-5; validation cohort: OR 6.50, 95% CI 1.83–23.17, P=0.0050). Periventricular nodular heterotopias (PNH) were the most frequent malformations and contained HTT and p62 aggregates analogous to the cortex, whereas cortical malformations with immature neuronal populations did not harbor such inclusions. HD individuals with malformations had heterozygous HTT CAG expansions between 40 and 52 repeats, were more frequently women, and all were asymmetric and focal, aside from one midline hypothalamic hamartoma. Using two independent brain bank cohorts, this large neuropathologic series demonstrates an increased occurrence of developmental malformations in HD brains. Since pathogenic HTT gene expansion is associated with genomic instability, one possible explanation is that neuronal precursors are more susceptible to somatic mutation of genes involved in cortical migration. Our findings further support emerging evidence that pathogenic trinucleotide repeat expansions of the HTT gene may impact neurodevelopment.


Author(s):  
Katherine L. Bryant ◽  
Dirk Jan Ardesch ◽  
Lea Roumazeilles ◽  
Lianne H. Scholtens ◽  
Alexandre A. Khrapitchev ◽  
...  

AbstractLarge-scale comparative neuroscience requires data from many species and, ideally, at multiple levels of description. Here, we contribute to this endeavor by presenting diffusion and structural MRI data from eight primate species that have not or rarely been described in the literature. The selected samples from the Primate Brain Bank cover a prosimian, New and Old World monkeys, and a great ape. We present preliminary labelling of the cortical sulci and tractography of the optic radiation, dorsal part of the cingulum bundle, and dorsal parietal–frontal and ventral temporal-frontal longitudinal white matter tracts. Both dorsal and ventral association fiber systems could be observed in all samples, with the dorsal tracts occupying much less relative volume in the prosimian than in other species. We discuss the results in the context of known primate specializations and present hypotheses for further research. All data and results presented here are available online as a resource for the scientific community.


2014 ◽  
Vol 91 ◽  
pp. 40-51 ◽  
Author(s):  
Il-Seuk Lee ◽  
Hong-Yoon Kang ◽  
Kyung-hwan Kim ◽  
In-Ho Kwak ◽  
Kwang-Ho Park ◽  
...  

2015 ◽  
Vol 40 (3-4) ◽  
pp. 121-129
Author(s):  
Welmoed A. Krudop ◽  
Sjanne Bosman ◽  
Jeroen J.G. Geurts ◽  
Sietske A.M. Sikkes ◽  
Nicolaas A. Verwey ◽  
...  

Aims: A clinical frontal lobe syndrome (FLS) is generally attributed to functional or structural disturbances within frontal-subcortical circuits. We studied the distribution of pathological brain changes in FLS. Additionally, the prevalence of FLS among various disorders was studied. Methods: We systematically screened clinical files of donors to the Netherlands Brain Bank (n = 2,814) for FLS. A total of 262 FLS cases were identified, and the distribution of postmortem pathological changes within the frontal-subcortical circuits was extracted from their neuropathological reports. Results: In 244 out of 262 patients (93%), pathological changes within the frontal-subcortical circuits were found: 90 subjects (34%) with frontal cortical pathology and 18 (7%) with pathology restricted to subcortical grey matter nuclei, whereas 136 subjects (52%) showed both cortical and subcortical pathology. In 18 subjects (7%), no pathology was found in the examined areas. The prevalence of FLS was highest in frontal-temporal lobar degeneration, followed by progressive supranuclear palsy and vascular dementia [χ2(6, n = 1,561) = 222.64, p < 0.01]. Conclusion: In this large brain bank study, the distribution of pathological changes in subjects with FLS was shown to be frontal-subcortical for the first time. A minority of FLS cases had pathology in the subcortical regions only or no frontal pathology at all.


2018 ◽  
Vol 132 ◽  
pp. 324-338 ◽  
Author(s):  
Bo Zhang ◽  
Zheng Meng ◽  
Lixiao Zhang ◽  
Xudong Sun ◽  
Tasawar Hayat ◽  
...  

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