scholarly journals The Role of Ovarian Hormones and the Medial Amygdala in Sexual Motivation

2017 ◽  
Vol 9 (4) ◽  
pp. 262-270 ◽  
Author(s):  
Mary K. Holder ◽  
Jessica A. Mong
Keyword(s):  
Sexual Motivation ◽  
Ovarian Hormones ◽  
Medial Amygdala

scholarly journals Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat

2019 ◽  
Vol 13 ◽  
Author(s):  
Sarah A. Rudzinskas ◽  
Katrina M. Williams ◽  
Jessica A. Mong ◽  
Mary K. Holder
Keyword(s):  
Sexual Motivation ◽  
Medial Amygdala ◽  
Female Rat

scholarly journals Progesterone after Estradiol Modulates Shuttle-Cage Escape by Facilitating Volition

2015 ◽  
Vol 9s1 ◽  
pp. JEN.S32735
Author(s):  
Darryl J. Mayeaux ◽  
Sarah M. Tandle ◽  
Sean M. Cilano ◽  
Matthew J. Fitzharris
Keyword(s):  
Depressive Symptoms ◽  
Animal Models ◽  
Electric Shock ◽  
Ovarian Hormones ◽  
Learning Task ◽  
The Other ◽  
Female Rats ◽  
Animal Models Of Depression ◽  
Escape Learning

In animal models of depression, depression is defined as performance on a learning task. That task is typically escaping a mild electric shock in a shuttle cage by moving from one side of the cage to the other. Ovarian hormones influence learning in other kinds of tasks, and these hormones are associated with depressive symptoms in humans. The role of these hormones in shuttle-cage escape learning, however, is less clear. This study manipulated estradiol and progesterone in ovariectomized female rats to examine their performance in shuttle-cage escape learning without intentionally inducing a depressive-like state. Progesterone, not estradiol, within four hours of testing affected latencies to escape. The improvement produced by progesterone was in the decision to act, not in the speed of learning or speed of escaping. This parallels depression in humans in that depressed people are slower in volition, in their decisions to take action.

scholarly journals Hypertensive response to stress: The role of histaminergic H1 and H2 receptors in the medial amygdala

2015 ◽  
Vol 144 ◽  
pp. 95-102 ◽  
Author(s):  
Daniela Oliveira de Almeida ◽  
Hilda Silva Ferreira ◽  
Luana Bomfim Pereira ◽  
Josmara Bartolomei Fregoneze
Keyword(s):  
Medial Amygdala ◽  
H2 Receptors ◽  
Response To Stress

Uterine epithelial LIF receptors contribute to implantation chamber formation in blastocyst attachment

Endocrinology ◽  
2021 ◽  
Author(s):  
Yamato Fukui ◽  
Yasushi Hirota ◽  
Tomoko Saito-Fujita ◽  
Shizu Aikawa ◽  
Takehiro Hiraoka ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Leukemia Inhibitory Factor ◽  
Ovarian Hormones ◽  
Signal Transducer ◽  
Blastocyst Implantation ◽  
Implantation Process ◽  
Uterine Glands ◽  
Transcription 3

Abstract Recent studies have demonstrated that the formation of an implantation chamber composed of a uterine crypt, an implantation-competent blastocyst, and uterine glands is a critical step in blastocyst implantation in mice. Leukemia inhibitory factor (LIF) activates signal transducer and activator of transcription 3 (STAT3) precursors via uterine LIF receptors (LIFRs), allowing successful blastocyst implantation. Our recent study revealed that the role of epithelial STAT3 is different from that of stromal STAT3. However, both are essential for blastocyst attachment, suggesting the different roles of epithelial and stromal LIFR in blastocyst implantation. However, how epithelial and stromal LIFR regulate the blastocyst implantation process remains unclear. To investigate the roles of LIFR in the uterine epithelium and stroma, we generated Lifr-floxed/lactoferrin (Ltf)-iCre (Lifr eKO) and Lifr-floxed/anti-Mullerian hormone receptor type 2 (Amhr2)-Cre (Lifr sKO) mice with deleted epithelial and stromal LIFR, respectively. Surprisingly, fertility and blastocyst implantation in the Lifr sKO mice were normal despite stromal STAT3 inactivation. In contrast, blastocyst attachment failed, and no implantation chambers were formed in the Lifr eKO mice with epithelial inactivation of STAT3. In addition, normal responsiveness to ovarian hormones was observed in the peri-implantation uteri of the Lifr eKO mice. These results indicate that the epithelial LIFR-STAT3 pathway initiates the formation of implantation chambers, leading to complete blastocyst attachment, and that stromal STAT3 regulates blastocyst attachment without stromal LIFR control. Thus, uterine epithelial LIFR is critical to implantation chamber formation and blastocyst attachment.

Role of ovarian hormones in age-associated thymic involution revisited

Immunobiology ◽  
2010 ◽  
Vol 215 (4) ◽  
pp. 275-293 ◽  
Author(s):  
Milica Perišić ◽  
Nevena Arsenović-Ranin ◽  
Ivan Pilipović ◽  
Duško Kosec ◽  
Vesna Pešić ◽  
...  
Keyword(s):  
Ovarian Hormones ◽  
Thymic Involution

scholarly journals Role of the posterodorsal medial amygdala in predator odour stress‐induced puberty delay in female rats

2019 ◽  
Vol 31 (6) ◽  
pp. e12719
Author(s):  
Xiao Feng Li ◽  
Daniel A. Adekunbi ◽  
Hussah M. Alobaid ◽  
Shengyun Li ◽  
Michel Pilot ◽  
...  
Keyword(s):  
Female Rats ◽  
Medial Amygdala ◽  
Predator Odour

scholarly journals Stress as a potential moderator of ovarian hormone influences on binge eating in women

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 222 ◽  
Author(s):  
Natasha Fowler ◽  
Phuong T. Vo ◽  
Cheryl L. Sisk ◽  
Kelly L. Klump
Keyword(s):  
Binge Eating ◽  
High Stress ◽  
Ovarian Hormones ◽  
Current Evidence ◽  
Ovarian Hormone ◽  
Moderating Effects ◽  
Response To Stress ◽  
Increased Sensitivity ◽  
As Stress

Previous research has demonstrated significant associations between increased levels of ovarian hormones and increased rates of binge eating (BE) in women. However, whereas all women experience fluctuations in ovarian hormones across the menstrual cycle, not all women binge eat in response to these fluctuations, suggesting that other factors must contribute. Stress is one potential contributing factor. Specifically, it may be that hormone-BE associations are stronger in women who experience high levels of stress, particularly as stress has been shown to be a precipitant to BE episodes in women. To date, no studies have directly examined stress as a moderator of hormone-BE associations, but indirect data (that is, associations between BE and stress and between ovarian hormones and stress) could provide initial clues about moderating effects. Given the above, the purpose of this narrative review was to evaluate these indirect data and their promise for understanding the role of stress in hormone-BE associations. Studies examining associations between all three phenotypes (that is, ovarian hormones, stress, and BE) in animals and humans were reviewed to provide the most thorough and up-to-date review of the literature on the potential moderating effects of stress on ovarian hormone–BE associations. Overall, current evidence suggests that associations between hormones and BE may be stronger in women with high stress levels, possibly via altered hypothalamic–pituitary–adrenal axis response to stress and increased sensitivity to and altered effects of ovarian hormones during stress. Additional studies are necessary to directly examine stress as a moderator of ovarian hormone–BE associations and identify the mechanisms underlying these effects.

Sex differences and the role of ovarian hormones in site-specific nociception of SHR

2019 ◽  
Vol 317 (2) ◽  
pp. R223-R231
Author(s):  
Bruna M. Santos ◽  
Glauce C. Nascimento ◽  
Camila P. Capel ◽  
Gabriela S. Borges ◽  
Thales Rosolen ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Ovarian Hormones ◽  
Accurate Diagnosis ◽  
Hypertensive Rats ◽  
Site Specific ◽  
Spontaneously Hypertensive ◽  
Inflammatory Nociception ◽  
The Individual ◽  
Orofacial Nociception

Accurate diagnosis and treatment of pain is dependent on knowledge of the variables that might alter this response. Some of these variables are the locality of the noxious stimulus, the sex of the individual, and the presence of chronic diseases. Among these chronic diseases, hypertension is considered a serious and silent disease that has been associated with hypoalgesia. The main goal of this study was to evaluate the potential nociceptive differences in spontaneously hypertensive rats (SHR) regarding the locality of the stimulus, i.e., the temporomandibular joint or paw, the sex, and the role of ovarian hormones in a model of mechanical nociception (Von Frey test) or formalin-induced inflammatory nociception. Our results indicate that SHR had lower orofacial mechanical nociception beyond the lower mechanical nociception in the paw compared with WKY rats. In a model of formalin-induced inflammatory nociception, SHR also had decreased nociception compared with normotensive rats. We also sought to evaluate the influence of sex and ovarian hormones on orofacial mechanical nociception in SHR. We observed that female SHR had higher mechanical nociception than male SHR only in the paw, but it had higher formalin-induced orofacial nociception than male SHR. Moreover, the absence of ovarian hormones caused an increase in mean arterial pressure and a decrease in paw nociception in female SHR.

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