scholarly journals CORR Insights®: Patients With Hip Osteoarthritis Have a Phenotype With High Bone Mass and Low Lean Body Mass

2014 ◽  
Vol 472 (4) ◽  
pp. 1230-1231
Author(s):  
Harri Sievänen
Keyword(s):  
Bone Mass ◽  
Lean Body Mass ◽  
Body Mass ◽  
Hip Osteoarthritis ◽  
High Bone Mass ◽  
High Bone

scholarly journals Patients With Hip Osteoarthritis Have a Phenotype With High Bone Mass and Low Lean Body Mass

2013 ◽  
Vol 472 (4) ◽  
pp. 1224-1229 ◽  
Author(s):  
Magnus K. Karlsson ◽  
Håkan Magnusson ◽  
Maria C. Cöster ◽  
Tord vonSchewelov ◽  
Caroline Karlsson ◽  
...  
Keyword(s):  
Bone Mass ◽  
Lean Body Mass ◽  
Body Mass ◽  
Hip Osteoarthritis ◽  
High Bone Mass ◽  
High Bone

scholarly journals Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
April Hartley ◽  
Sarah A. Hardcastle ◽  
Monika Frysz ◽  
Jon Parkinson ◽  
Lavinia Paternoster ◽  
...  
Keyword(s):  
Bone Mass ◽  
Functional Limitations ◽  
Functional Limitation ◽  
Hip Osteoarthritis ◽  
Joint Space ◽  
Mineral Density ◽  
High Bone Mass ◽  
High Bone ◽  
Subchondral Sclerosis

Abstract Background Individuals with high bone mass (HBM) have a greater odds of prevalent radiographic hip osteoarthritis (OA), reflecting an association with bone-forming OA sub-phenotypes (e.g. osteophytosis, subchondral sclerosis). As the role of bone mineral density (BMD) in hip OA progression is unclear, we aimed to determine if individuals with HBM have increased incidence and/or progression of bone-forming OA sub-phenotypes. Methods We analysed an adult cohort with and without HBM (L1 and/or total hip BMD Z-score > + 3.2) with pelvic radiographs collected at baseline and 8-year follow-up. Sub-phenotypes were graded using the OARSI atlas. Superior/inferior acetabular/femoral osteophyte and medial/superior joint space narrowing (JSN) grades were summed and Δosteophyte and ΔJSN derived. Pain and functional limitations were quantified using the WOMAC questionnaire. Associations between HBM status and change in OA sub-phenotypes were determined using multivariable linear/logistic regression, adjusting for age, sex, height, total body fat mass, follow-up time and baseline sub-phenotype grade. Generalised estimating equations accounted for individual-level clustering. Results Of 136 individuals, 62% had HBM at baseline, 72% were female and mean (SD) age was 59 (10) years. HBM was positively associated with both Δosteophytes and ΔJSN (adjusted mean grade differences between individuals with and without HBM βosteophyte = 0.30 [0.01, 0.58], p = 0.019 and βJSN = 0.10 [0.01, 0.18], p = 0.019). Incident subchondral sclerosis was rare. HBM individuals had higher WOMAC hip functional limitation scores (β = 8.3 [0.7, 15.98], p = 0.032). Conclusions HBM is associated with the worsening of hip osteophytes and JSN over an average of 8 years, as well as increased hip pain and functional limitation.

scholarly journals The prevalence of radiographic hip osteoarthritis is increased in high bone mass; a case-control study

2014 ◽  
Vol 22 ◽  
pp. S343
Author(s):  
S.A. Hardcastle ◽  
P. Dieppe ◽  
C.L. Gregson ◽  
D. Hunter ◽  
G. Thomas ◽  
...  
Keyword(s):  
Bone Mass ◽  
Case Control Study ◽  
Hip Osteoarthritis ◽  
Case Control ◽  
High Bone Mass ◽  
High Bone ◽  
Control Study

scholarly journals Prevalence of radiographic hip osteoarthritis is increased in high bone mass

2014 ◽  
Vol 22 (8) ◽  
pp. 1120-1128 ◽  
Author(s):  
S.A. Hardcastle ◽  
P. Dieppe ◽  
C.L. Gregson ◽  
D. Hunter ◽  
G.E.R. Thomas ◽  
...  
Keyword(s):  
Bone Mass ◽  
Hip Osteoarthritis ◽  
High Bone Mass ◽  
High Bone

scholarly journals High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index

Bone ◽  
2017 ◽  
Vol 97 ◽  
pp. 306-313 ◽  
Author(s):  
C.L. Gregson ◽  
S.A. Hardcastle ◽  
A. Murphy ◽  
B. Faber ◽  
W.D. Fraser ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Bone Mass ◽  
Body Mass ◽  
Weight Bearing ◽  
High Bone Mass ◽  
High Bone

scholarly journals 189. High Bone Mass is Associated with an Increased Prevalence of Radiographic Hip Osteoarthritis: A Case-Control Study

Rheumatology ◽  
2014 ◽  
Vol 53 (suppl_1) ◽  
pp. i130-i130
Author(s):  
Sarah A. Hardcastle ◽  
Paul Dieppe ◽  
Celia L. Gregson ◽  
David Hunter ◽  
Geraint Thomas ◽  
...  
Keyword(s):  
Bone Mass ◽  
Case Control Study ◽  
Hip Osteoarthritis ◽  
Case Control ◽  
High Bone Mass ◽  
High Bone ◽  
Control Study

scholarly journals Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men

2013 ◽  
Vol 98 (2) ◽  
pp. 818-828 ◽  
Author(s):  
Celia L. Gregson ◽  
Margaret A. Paggiosi ◽  
Nicola Crabtree ◽  
Sue A. Steel ◽  
Eugene McCloskey ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Bone Mass ◽  
Bone Turnover ◽  
Body Mass ◽  
Fat Mass ◽  
Lean Mass ◽  
High Bone Mass ◽  
High Bone ◽  
Dxa Scans

Abstract Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear. Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover. Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. A total of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls. Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers. Results: Among women, fat mass was inversely related to age in controls (P = .01), but not in HBM cases (P = .96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, P < .001). Increased fat mass in male HBM cases was less marked (gender interaction P = .03). Compared with controls, lean mass was also increased in female HBM cases (by 3.3 [1.2, 5.4] kg; P < .002); however, lean mass increases were less marked than fat mass increases, resulting in 4.5% lower percentage lean mass in HBM cases (P < .001). Osteocalcin was also lower in female HBM cases compared with controls (by 2.8 [0.1, 5.5] μg/L; P = .04). Differences in fat mass were fully attenuated after hip bone mineral density (BMD) adjustment (P = .52) but unchanged after adjustment for bone turnover (P < .001), whereas the greater hip BMD in female HBM cases was minimally attenuated by fat mass adjustment (P < .001). Conclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover.

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