Implausible high bone mass density scores as assessed at the lumbar spine by dual X-ray absorptiometry and their correlation with conventional X-ray studies

Abstract Purpose It is still not clear whether to screen women with primary premature ovarian insufficiency for autoimmunity. Moreover, a possible association of autoimmunity with decreased bone mass density in premature ovarian insufficiency patients has not been evaluated. Thus, the objectives of this study were to review our experience with the use of an autoimmune screening panel in premature ovarian insufficiency women and to focus on bone mass density. Methods In a retrospective cohort study, 76 chromosomally normal women with primary premature ovarian insufficiency were included. The main outcome parameters were the results of an autoimmune screening panel and of dual-energy X-ray absorptiometry. Results Median age was 33 years. Sixty percent of premature ovarian insufficiency patients revealed abnormal dual-energy X-ray absorptiometry results (minimal T-score < −1.0). Any signs of autoimmunity were found in 21 women (36.2%). The most frequent abnormal results were increased thyroperoxidase antibodies (24.1%) and thyroglobulin antibodies (20.7%). A longer duration of amenorrhea (β = −0.015; p = 0.007), any abnormality during autoimmune screening (β = −0.940; p = 0.010), and a lower body mass index (β = −0.057; p = 0.036) were associated with a lower minimal T-score. Conclusion In chromosomally normal women with primary premature ovarian insufficiency, the prevalence of autoimmunity and decreased bone mass density seem high. Our data highlight the association between autoimmune abnormalities and decreased dual-energy X-ray absorptiometry results.

Download Full-text

A study on bone mass density using dual energy X-ray absorptiometry: Does high body mass index have protective effect on bone density in obese patients?

Journal of Research in Medical Sciences ◽

10.4103/jrms.jrms_1066_18 ◽

2020 ◽

Vol 25 (1) ◽

pp. 4

Author(s):

Shadi Ebrahimian ◽

Azin Shayganfar ◽

Mahsa Masjedi ◽

Sadaf Daryaei

Keyword(s):

Body Mass Index ◽

Bone Density ◽

Bone Mass ◽

Protective Effect ◽

Mass Density ◽

High Body Mass Index ◽

Dual Energy ◽

Bone Mass Density ◽

Obese Patients ◽

X Ray

Download Full-text

FRI0638 LUMBAR SPINE BONE MASS DENSITY AS A PREDICTOR OF FRACTURES IN PATIENTS WITH COELIAC DISEASE: AN OBSERVATIONAL STUDY

10.1136/annrheumdis-2019-eular.4541 ◽

2019 ◽

Author(s):

Mariam Gaddah ◽

Marwan Bukhari

Keyword(s):

Lumbar Spine ◽

Observational Study ◽

Bone Mass ◽

Coeliac Disease ◽

Mass Density ◽

Bone Mass Density

Download Full-text

Hubungan fraksi area trabekula anterior mandibula dengan kepadatan tulang lumbar spine untuk deteksi dini osteoporosis

Majalah Kedokteran Gigi Indonesia ◽

10.22146/majkedgiind.13207 ◽

2017 ◽

Vol 3 (1) ◽

pp. 43

Author(s):

Sri Lestari ◽

Rini Widyaningrum

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mass ◽

Trabecular Bone ◽

Bone Mineral ◽

Mass Density ◽

Area Fraction ◽

Bone Mass Density ◽

Mineral Density ◽

Anterior Mandible

The relationship of anterior mandible trabecular area with bone mass density of lumbar spine for early detection of osteoporosis. Bone mineral density is an indicator of osteoporosis, including the bone mineral density of lumbar spine. The decrease of lumbar spine bone mass density will cause an alteration in another site, including the mandibular. The aim of this research is to determine the predictor of lumbar spine bone mineral density using trabecular bone image of anterior mandible on periapical radiographs. The research was conducted by extracting the area fraction at mandible trabecular bone using digital periapical radiograph from 25 subjects. Canny edge detection was used in digital image processing for each radiograph. The regions of interest were selected from the image obtained by canny edge detection, so that the area fraction could be measured. A linier regression test was applied to determine a relationship between the area fractions of mandible trabecular bone with the bone mineral density of lumbar spine. The result of linear regression test showed that the area fraction of mandible trabecular bone had a moderate negative correlation with bone mass density of lumbar spine (α = 0.046; R = -0.403). The direction of the correlation was negative (b = -0.145). The area fraction of mandible trabecular bone on periapical radiographs could be used as the predictor for bone mass density of lumbar spine.ABSTRAKKepadatan tulang merupakan indikator osteoporosis, salah satu diantaranya adalah kepadatan tulang pada lumbar spine. Penurunan kepadatan tulang pada lumbar spine mempengaruhi kondisi tulang lain, termasuk tulang rahang bawah (mandibula). Tujuan penelitian ini adalah untuk menentukan prediktor densitas mineral tulang menggunakan citra radiograf periapikal tulang trabekula pada regio anterior rahang bawah. Penelitian dilakukan dengan ekstraksi fraksi area tulang trabekula mandibula yang tercitrakan pada radiograf periapikal digital dari 25 subjek. Pengolahan citra digital pada radiograf periapikal dilakukan dengan menggunakan metode deteksi tepi canny terhadap masing-masing citra radiograf. Region of Interest diseleksi dari citra hasil deteksi canny, sehingga dapat dilakukan pengukuran fraksi area. Uji regresi linier dilakukan untuk mengetahui hubungan antara nilai fraksi area trabekula mandibula dengan tingkat kepadatan tulang pada lumbar spine. Hasil uji regresi linier menunjukkan bahwa nilai fraksi area trabekula mandibula berkorelasi negatif dengan kepadatan tulang dengan kekuatan sedang (α = 0,046; R = -0,403). Adapun arah korelasi antara nilai fraksi area trabekula mandibula dengan kepadatan tulang adalah negatif (b = -0,145). Fraksi area tulang trabekula pada citra radiograf periapikal dapat digunakan sebagai prediktor kepadatan tulang pada lumbar spine.

Download Full-text

Pioglitazone Therapy Decreases Bone Mass Density and Increases Fat Mass: A Meta-Analysis

Current Pharmaceutical Design ◽

10.2174/1381612825666190920123129 ◽

2019 ◽

Vol 25 (33) ◽

pp. 3590-3596 ◽

Cited By ~ 2

Author(s):

Liyun Zuo ◽

Jianbin Wang ◽

Nianping Zhang ◽

Junjie Wang

Keyword(s):

Lumbar Spine ◽

Bone Mass ◽

Bone Metabolism ◽

Fat Mass ◽

Mass Density ◽

Meta Analysis ◽

Whole Body ◽

Bone Mass Density ◽

Turnover Markers ◽

Serum Pth

Background: Pioglitazone is mainly used for the management of type 2 diabetes and other insulinassociated diseases. However, the molecular mechanism of pioglitazone can lead to an imbalance in bone metabolism, thus decreasing bone mass density (BMD) and increasing the risk for fractures. Objective: To demonstrate the effect of pioglitazone therapy on bone metabolism and fat mass. Methods: A comprehensive search of the PubMed, EMBASE, Web of Science and Cochrane Central databases for randomized controlled trials (RCTs) on the effect of pioglitazone therapy on BMD and fat mass was performed. The primary outcome measures were the measured values of BMD, percentage changes in BMD, measured values of bone turnover markers and bone metabolic hormones, changes in BMI, body and leg fat mass, and fracture rates. The final search was performed in May 2019. Results: Six RCTs were included. A total of 749 patients met the inclusion criteria. Pioglitazone therapy was shown to significantly reduce the BMD of the whole body, lumbar spine, and total hip and serum PTH levels and increase BMI, total body fat mass and leg fat mass. In addition, 30 mg/d and 30 mg/d initially for one month followed by 45 mg/d pioglitazone could reduce the BMD of the lumbar spine. Pioglitazone therapy exerted no significant influence on the BMD of the femoral neck, serum BSAP or 25-OHD levels, or fracture rates. Conclusion: Compared with placebo, pioglitazone therapy reduced BMD and serum PTH levels and increased fat mass and BMI with no difference in serum BSAP or 25-OHD levels or fracture rates; 30 mg/d pioglitazone was sufficient to reduce the BMD of the lumbar spine.

Download Full-text

SAT0469 PROSPECTIVE STUDY ASSESSING BONE MINERAL DENSITY AND RISK FACTORS FOR OSTEOPOROSIS IN PATIENTS WITH ANDROGEN DEPRIVATION THERAPY. PRELIMINARY CROSS-SECTIONAL RESULTS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.5204 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1192.2-1192

Author(s):

L. Gifre ◽

F. Elias ◽

P. Servian ◽

R. Freixa ◽

O. Buisan Rueda

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Bone Mass ◽

Prospective Study ◽

Fragility Fractures ◽

Mineral Density ◽

High Bone Mass ◽

Cross Sectional ◽

X Ray ◽

High Bone

Background:Few studies have analysed the incidence and risk factors for osteoporosis (OP) development in patients with prostate cancer (PC) and androgen deprivation therapy (ADT).Objectives:To assess risk factors for OP, bone turnover markers (BTM) and bone mineral density (BMD) in a cohort of patients with ADT, as well as the duration of ADT and previous treatments received for PC.Methods:Ongoing prospective study including patients with ADT for PC. Risk factors for OP, BTM (total ALP, bone ALP, CTx), spinal X-Ray and BMD (Lunar, DPX) were assessed yearly since inclusion in the study (April 2018). Patients with known OP or previous antiosteoporotic treatment were excluded. The study was approved by the ethics committee, and all patients gave their signed consent. Herein we present the preliminary cross-sectional study at inclusion.Results:Of the 83 patients attended at the Rheumatology Department during the study period, 75 were included with a mean age 75±5years and median ADT duration of 1 year. 18 were receiving concomitant radiotherapy and 7 docetaxel.When assessing risk factors for OP: 28% had previous fragility fractures and 24% had current alcohol intake. After X-Ray assessment, 14% had morphometric vertebral fractures. Mean 25OHD at inclusion was 19±9ng/ml (73% had 25OHD <30ng/ml) and mean testosterone was 82±162ng/dL (75% had levels <50ng/dl). All patients had increased values of CTx and 9% had increased bone ALP levels.BMD showed up to 28% with densitometric OP and osteopenia in 56%. Patients with OP were older (83±7 vs 74±8 years, p=0.021), had lower testosterone levels (16 vs 89 ng/dl, p=0.004), as expected lower BMD (at spine, proximal femur and even distal radius) and had more previous fragility fracture (75 vs 19%, p=0.022). But it should be noted that 16% had high bone mass (HBM) mostly affecting spine BMD (in 6 patients combined with femoral osteopenia). All patients with HBM had high bone metastatic disease, and no differences were observed between patients with/without HBM when comparing BTM or calcium-phosphate metabolism.Conclusion:Low bone mass (including osteoporosis and osteopenia) is frequent in patients with ADT as well as previous fragility fractures. Up to 16% had high bone mass, being mostly in patients with high volume metastatic disease. Thus, all patients with ADT should undergo a bone health assessment and start antiosteoporotic treatment if required.Disclosure of Interests:None declared

Download Full-text

Prevalence of low bone mineral density in adolescents and adults with cystic fibrosis

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.60.01.012 ◽

2014 ◽

Vol 60 (1) ◽

pp. 53-58 ◽

Cited By ~ 5

Author(s):

Roberta Vanacor ◽

Fabiana V. Raimundo ◽

Natália A. Marcondes ◽

Bruno P. Corte ◽

Aline M. Ascoli ◽

...

Keyword(s):

Body Mass Index ◽

Cystic Fibrosis ◽

Lumbar Spine ◽

Bone Mass ◽

Body Mass ◽

Mass Density ◽

Bone Mass Density ◽

Z Score ◽

Low Bone Mass ◽

Mineral Density

Objective The aim of this cross-sectional study was to evaluate the prevalence of low bone mass density in cystic fibrosis patients as well as to evaluate the factors associated with bone mass in such patients. Methods Bone mass density was measured by dual-photon X-ray absorptiometry of lumbar spine (L1-L4), in patients ≤19 years old, or lumbar spine and femur (total and neck) in patients ≥20 years old. Evaluations of nutritional status, biochemical parameters, and lung function were performed. Medication data were obtained from medical records. Results Fifty-eight patients were included in the study (25 males/ 33 females), mean age 23.9 years (16-53years). The prevalence of bone mass below the expected range for age at any site was 20.7%. None of the subjects had history of fracture. Lumbar spine Z-score in cystic fibrosis patients correlated positively with body mass index (r= 0.3, p=0.001), and forced expiratory volume in the first second (% predicted) (r=0.415, p=0.022). Mean lumbar spine Z-score was higher in women (p=0.001), in patients with no pancreatic insufficiency (p=0.032), and in patients with no hospitalization in the last 3 months (p=0.02). After multivariate analysis, body mass index (p= 0.001) and sex (p=0.001) were independently associated with Z-score in lumbar spine. Conclusion Low bone mass is a frequent problem in patients with CF, being independently associated with body mass index, and male sex.

Download Full-text