Sea Buckthorn Leaf Extract Inhibits Glioma Cell Growth by Reducing Reactive Oxygen Species and Promoting Apoptosis

2017 ◽  
Vol 182 (4) ◽  
pp. 1663-1674 ◽  
Author(s):  
Sung-Jo Kim ◽  
Eunmi Hwang ◽  
Sun Shin Yi ◽  
Ki Duk Song ◽  
Hak-Kyo Lee ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Growth ◽  
Glioma Cell ◽  
Leaf Extract ◽  
Reactive Oxygen ◽  
Sea Buckthorn ◽  
Oxygen Species

scholarly journals Blockage of Potassium Channel Inhibits Proliferation of Glioma Cells Via Increasing Reactive Oxygen Species

2014 ◽  
Vol 22 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Li Hu ◽  
Li-Li Li ◽  
Zhi-Guo Lin ◽  
Zhi-Chao Jiang ◽  
Hong-Xing Li ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Reactive Oxygen ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Brain Glioma ◽  
Protein Levels ◽  
Glioma Cell Proliferation

The potassium (K+) channel plays an important role in the cell cycle and proliferation of tumor cells, while its role in brain glioma cells and the signaling pathways remains unclear. We used tetraethylammonium (TEA), a nonselective antagonist of big conductance K+ channels, to block K+ channels in glioma cells, and antioxidant N-acetyl-l-cysteine (NAC) to inhibit production of intracellular reactive oxygen species (ROS). TEA showed an antiproliferation effect on C6 and U87 glioma cells in a time-dependent manner, which was accompanied by an increased intracellular ROS level. Antioxidant NAC pretreatment reversed TEA-mediated antiproliferation and restored ROS level. TEA treatment also caused significant increases in mRNA and protein levels of tumor-suppressor proteins p53 and p21, and the upregulation was attenuated by pretreatment of NAC. Our results suggest that K+ channel activity significantly contributes to brain glioma cell proliferation via increasing ROS, and it might be an upstream factor triggering the activation of the p53/p21Cip1-dependent signaling pathway, consequently leading to glioma cell cycle arrest.

Reactive oxygen species produced by NADPH oxidase regulate plant cell growth

Nature ◽  
2003 ◽  
Vol 422 (6930) ◽  
pp. 442-446 ◽  
Author(s):  
Julia Foreman ◽  
Vadim Demidchik ◽  
John H. F. Bothwell ◽  
Panagiota Mylona ◽  
Henk Miedema ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Growth ◽  
Nadph Oxidase ◽  
Plant Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Plant Cell Growth

Silver nanoparticles synthesized from Adenium obesum leaf extract induced DNA damage, apoptosis and autophagy via generation of reactive oxygen species

2016 ◽  
Vol 141 ◽  
pp. 158-169 ◽  
Author(s):  
Mohammad Abul Farah ◽  
Mohammad Ajmal Ali ◽  
Shen-Ming Chen ◽  
Ying Li ◽  
Fahad Mohammad Al-Hemaid ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma

Surgery ◽  
2015 ◽  
Vol 158 (3) ◽  
pp. 827-836 ◽  
Author(s):  
Yueming Zhu ◽  
Pritha Paul ◽  
Sora Lee ◽  
Brian T. Craig ◽  
Eric J. Rellinger ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Steady State ◽  
Cell Growth ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Anticancer effect of icaritin inhibits cell growth of colon cancer through reactive oxygen species, Bcl-2 and cyclin D1/E signaling

2016 ◽  
Vol 12 (5) ◽  
pp. 3537-3542 ◽  
Author(s):  
Chaofeng Li ◽  
Weichao Peng ◽  
Xin Song ◽  
Qian Wang ◽  
Wenyue Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Colon Cancer ◽  
Cell Growth ◽  
Cyclin D1 ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Anticancer Effect
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