scholarly journals Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides

2021 ◽  
Author(s):  
Wen-Xia Duan ◽  
Xiao-Hua Yang ◽  
Hua-Feng Zhang ◽  
Jing Feng ◽  
Meng-Yuan Zhang
Keyword(s):  
Mechanism Of Action ◽  
Chemical Structure ◽  
Hypoglycemic Activity

Mechanism of Action of the Herbicide 4,6-Dinitro-o-cresol in Photosynthesis

1979 ◽  
Vol 34 (11) ◽  
pp. 1021-1023 ◽  
Author(s):  
J. J. S. van Rensen ◽  
J. H. Hobé
Keyword(s):  
Electron Transport ◽  
Photosystem Ii ◽  
Mechanism Of Action ◽  
Chemical Structure ◽  
Methyl Viologen ◽  
Primary Electron ◽  
Reaction Centers ◽  
Mehler Reaction ◽  
Cyclic Photophosphorylation ◽  
Primary Electron Acceptor

Abstract The herbicide 4,6-dinitro-o-cresol inhibits electron transport to ferricyanide and non-cyclic photophosphorylation for 50% at about 15 μm. At higher concentrations the photosystem I depen­dent Mehler reaction ascorbate/dichlorophenolindophenol to methyl viologen is stimulated, while cyclic photophosphorylation is inhibited. The herbicide thus is an inhibitory uncoupler. Although the chemical structure of 4,6-dinitro-o-cresol is different from that of the diuron-type herbicides, its site and mechanism of action is similar. Both 4,6-dinitro-o-cresol and diuron inhibit electron transport between the primary electron acceptor of Photosystem II and the plastoquinone pool. This causes a closing of the reaction centers of Photosystem II. The interaction with the inhibited molecule however is different for the two herbicides.

Hypoglycemic Activity and Chemical Structure of the Salicylates

1968 ◽  
Vol 57 (12) ◽  
pp. 2111-2116 ◽  
Author(s):  
Victor Fang ◽  
William O. Foye ◽  
Sumner M. Robinson ◽  
Howard J. Jenkins
Keyword(s):  
Chemical Structure ◽  
Hypoglycemic Activity

The situation of small molecules targeting key proteins to combat SARS-CoV-2: Synthesis, metabolic pathway, mechanism of action, and potential therapeutic applications

2021 ◽  
Vol 21 ◽  
Author(s):  
Farzaneh Sorouri ◽  
Zahra Emamgholipour ◽  
Maryam Keykhaee ◽  
Alireza Najafi ◽  
Loghman Firoozpour ◽  
...  
Keyword(s):  
Small Molecules ◽  
Mechanism Of Action ◽  
Metabolic Pathway ◽  
Chemical Structure ◽  
Pediatric Patients ◽  
New Drugs ◽  
Protein Targets ◽  
Global Epidemic ◽  
Therapeutic Applications ◽  
Stimulation Of

: Due to the global epidemic and high mortality of 2019 coronavirus disease (COVID-19), there is an immediate need to discover drugs that can help before a vaccine becomes available. Given that the process of producing new drugs is so long, the strategy of repurposing existing drugs is one of the promising options for the urgent treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease. Although FDA has approved Remdesivir for the use in hospitalized adults and pediatric patients suffering from COVID-19, no fully effective and reliable drug has been yet identified worldwide to treat COVID-19 specifically. Thus, scientists are still trying to find antivirals specific to COVID-19. This work reviews the chemical structure, metabolic pathway, mechanism of action of existing drugs with potential therapeutic applications for COVID-19. Further, we summarized the molecular docking stimulation of the medications related to key protein targets. These already drugs could be developed for further clinical trials to supply suitable therapeutic options for patients suffering from COVID-19.

scholarly journals Antimicrobial and cell-compatible surface-attached polymer networks – how the correlation of chemical structure to physical and biological data leads to a modified mechanism of action

2015 ◽  
Vol 3 (30) ◽  
pp. 6224-6238 ◽  
Author(s):  
Peng Zou ◽  
Dougal Laird ◽  
Esther K. Riga ◽  
Zhuoling Deng ◽  
Franziska Dorner ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Mechanism Of Action ◽  
Chemical Structure ◽  
Polymer Networks ◽  
Biological Data ◽  
Physical Parameters

In this paper, we investigate the correlation of physical parameters and antimicrobial activity.

NEW ORIGINAL DRUG ROSEOFUNGIN-AS, OINTMENT 2%

2021 ◽  
pp. 55-64
Author(s):  
А.К. САДАНОВ ◽  
В.Э. БЕРЕЗИН ◽  
И.Р. КУЛМАГАМБЕТОВ ◽  
Л.П. ТРЕНОЖНИКОВА ◽  
А.С. БАЛГИМБАЕВА
Keyword(s):  
Clinical Trials ◽  
Drug Development ◽  
Physicochemical Properties ◽  
Phase I ◽  
Mechanism Of Action ◽  
Chemical Structure ◽  
Antifungal Drug ◽  
Polyene Antibiotic

В статье приводятся сведения о разработке нового отечественного противогрибкового препарата «Розеофунгин-АС, мазь 2%» для наружного применения на основе оригинального природного полиенового антибиотика розеофунгина. Приводятся данные о продуценте антибиотика, процессе его биосинтеза и получения, его физико-химических свойствах и химической структуре, рассматриваются его антифунгальные и антивирусные свойства, механизм его действия, а также основные этапы разработки противогрибкового препарата - доклинические и I, II и III фазы клинических исследований. This paper provides the information on the development of new domestic antifungal drug Roseofungin-AS, ointment 2% for external use based on the original natural polyene antibiotic roseofungin. Data on the antibiotic producer, the process of its biosynthesis and production, its physicochemical properties and chemical structure are presented, its antifungal and antiviral properties, the mechanism of action as well as the main stages of the antifungal drug development including preclinical and phase I, II, III clinical trials are discussed.

Application of reporter strains for new antibiotic screening

2016 ◽  
Vol 62 (2) ◽  
pp. 117-123 ◽  
Author(s):  
P.V. Sergiev ◽  
I.A. Osterman ◽  
A.Ya. Golovina ◽  
I.G. Laptev ◽  
P.I. Pletnev ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Early Identification ◽  
Chemical Structure ◽  
Medical Science ◽  
Primary Screening ◽  
Antibiotic Screening ◽  
New Antibiotics ◽  
Reporter Strains

Screening for new antibiotics remains an important area of biology and medical science. Indispensable for this type of research is early identification of antibiotic mechanism of action. Preferentially, it should be studied quickly and cost-effectively, on the stage of primary screening. In this review we describe an application of reporter strains for rapid classification of antibiotics by its target, without prior purification of an active compound and determination of chemical structure

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