The Wnt Signal Transduction Pathway in Stem Cells and Cancer Cells: Influence on Cellular Invasion

2007 ◽  
Vol 3 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Peter Neth ◽  
Christian Ries ◽  
Marisa Karow ◽  
Virginia Egea ◽  
Matthias Ilmer ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Stem Cells ◽  
Cancer Cells ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Cellular Invasion ◽  
Wnt Signal

scholarly journals Bone Marrow Mesenchymal Stem Cells (BM-MSCs) Improve Heart Function in Swine Myocardial Infarction Model through Paracrine Effects

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Min Cai ◽  
Rui Shen ◽  
Lei Song ◽  
Minjie Lu ◽  
Jianguang Wang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Signal Transduction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Glucose Metabolism ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Pet Ct ◽  
Marrow Mesenchymal Stem Cells

Abstract Stem cells are promising for the treatment of myocardial infarction (MI) and large animal models should be used to better understand the full spectrum of stem cell actions and preclinical evidences. In this study, bone marrow mesenchymal stem cells (BM-MSCs) were transplanted into swine heart ischemia model. To detect glucose metabolism in global left ventricular myocardium and regional myocardium, combined with assessment of cardiac function, positron emission tomography-computer tomography (PET-CT) and magnetic resonance imaging (MRI) were performed. To study the changes of glucose transporters and glucose metabolism-related enzymes and the signal transduction pathway, RT-PCR, Western-blot, and immunohistochemistry were carried out. Myocardium metabolic evaluation by PET-CT showed that mean signal intensity (MSI) increased in these segments at week 4 compared with that at week 1 after BM-MSCs transplantation. Moreover, MRI demonstrated significant function enhancement in BM-MSCs group. The gene expressions of glucose transporters (GLUT1, GLUT4), glucose metabolism-related enzymes phosphofructokinase (PFK), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH)) and 70-kDa ribosomal protein S6 kinase (p70s6k) in BM-MSCs injected areas were up-regulated at week 4 after BM-MSCs transplantation and this was confirmed by Western-blot and immunohistochemistry. In conclusions, BM-MSCs transplantation could improve cardiac function in swine MI model by activation of mTOR signal transduction pathway.

scholarly journals Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth

FEBS Letters ◽  
2002 ◽  
Vol 530 (1-3) ◽  
pp. 59-64 ◽  
Author(s):  
Yasunori Kadowaki ◽  
Shunji Ishihara ◽  
Youichi Miyaoka ◽  
Mohammed Azharul Karim Rumi ◽  
Hiroshi Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signal Transduction ◽  
Cancer Cells ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Gastric Cancer Cells

scholarly journals Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity

2007 ◽  
Vol 178 (3) ◽  
pp. 355-361 ◽  
Author(s):  
Karni Schlessinger ◽  
Edward J. McManus ◽  
Alan Hall
Keyword(s):  
Signal Transduction ◽  
Wnt Signaling Pathway ◽  
Signal Transduction Pathway ◽  
Leading Edge ◽  
Transduction Pathway ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Gsk 3Β ◽  
Apc Protein ◽  
Wnt Signal

Scratch-induced disruption of cultured monolayers induces polarity in front row cells that can be visualized by spatially localized polymerization of actin at the front of the cell and reorientation of the centrosome/Golgi to face the leading edge. We previously reported that centrosomal reorientation and microtubule polarization depend on a Cdc42-regulated signal transduction pathway involving activation of the Par6/aPKC complex followed by inhibition of GSK-3β and accumulation of the adenomatous polyposis coli (APC) protein at the plus ends of leading-edge microtubules. Using monolayers of primary rodent embryo fibroblasts, we show here that dishevelled (Dvl) and axin, two major components of the Wnt signaling pathway are required for centrosome reorientation and that Wnt5a is required for activation of this pathway. We conclude that disruption of cell–cell contacts leads to the activation of a noncanonical Wnt/dishevelled signal transduction pathway that cooperates with Cdc42/Par6/aPKC to promote polarized reorganization of the microtubule cytoskeleton.

scholarly journals Study of metformin effects in mTOR/S6Ks signal transduction pathway in lung cancer cells

2016 ◽  
Author(s):  
ANA PAULA MORELLI ◽  
Fernando Moreira Simabuco ◽  
THARCISIO CITRANGULO TORTELLI JUNIOR ◽  
ROGER CHAMMAS
Keyword(s):  
Lung Cancer ◽  
Signal Transduction ◽  
Cancer Cells ◽  
Signal Transduction Pathway ◽  
Lung Cancer Cells ◽  
Transduction Pathway

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

Development ◽  
1995 ◽  
Vol 121 (6) ◽  
pp. 1637-1647 ◽  
Author(s):  
S.Y. Sokol ◽  
J. Klingensmith ◽  
N. Perrimon ◽  
K. Itoh
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathway ◽  
Neural Induction ◽  
Neural Tissue ◽  
Lineage Tracing ◽  
Axis Formation ◽  
Transduction Pathway ◽  
Vertebrate Development ◽  
Dorsal Axis ◽  
Wnt Signal

Signaling factors of the Wnt proto-oncogene family are implicated in dorsal axis formation during vertebrate development, but the molecular mechanism of this process is not known. Studies in Drosophila have indicated that the dishevelled gene product is required for wingless (Wnt1 homolog) signal transduction. We demonstrate that injection of mRNA encoding a Xenopus homolog of dishevelled (Xdsh) into prospective ventral mesodermal cells triggers a complete dorsal axis formation in Xenopus embryos. Lineage tracing experiments show that cells derived from the injected blastomere contribute to anterior and dorsal structures of the induced axis. In contrast to its effect on mesoderm, overexpression of Xdsh mRNA in prospective ectodermal cells triggers anterior neural tissue differentiation. These studies suggest that Wnt signal transduction pathway is conserved between Drosophila and vertebrates and point to a role for maternal Xdsh product in dorsal axis formation and in neural induction.

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