Common Methodologies in the Evaluation of Food Allergy: Pitfalls and Prospects of Food Allergy Prevalence Studies

2012 ◽  
Vol 46 (3) ◽  
pp. 198-210 ◽  
Author(s):  
Shang-an Shu ◽  
Christopher Chang ◽  
Patrick S. C. Leung
2020 ◽  
Vol 55 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Mark Messina ◽  
Carina Venter

2020 ◽  
Vol 68 (6) ◽  
pp. 1152-1155
Author(s):  
Joan H Dunlop

The US Food and Drug Administration’s approval of a peanut oral immunotherapy product in January 2020 is a landmark development in the field of food allergy therapy. While food allergy prevalence has been increasing, this product is the first approved therapy for food allergy. Oral immunotherapy has many similarities to subcutaneous immunotherapy and drug desensitization protocols, but does not lead to sustained unresponsiveness. The studies leading to approval of the Palforzia product demonstrated increase in the amount of peanut protein able to be consumed, with 67% of subjects randomized to the treatment arm able to consume 600 mg of peanut protein in double-blind placebo-controlled food challenge at study exit. However, side effects are an important consideration, and dropout rates in studies of Palforzia ranged from 11% to 21%. Postmarketing surveillance of this product will be critical in assessing its long-term risks and benefits.


2020 ◽  
Vol 145 (2) ◽  
pp. AB182
Author(s):  
Andrea Pappalardo ◽  
Christopher Warren ◽  
Jialing Jiang ◽  
Ruchi Gupta

2014 ◽  
Vol 24 (7) ◽  
pp. 551-553 ◽  
Author(s):  
Jerel M. Ezell ◽  
Dennis R. Ownby ◽  
Edward M. Zoratti ◽  
Suzanne Havstad ◽  
Charlotte Nicholas ◽  
...  

Author(s):  
Jenny Garkaby ◽  
Larisa Epov ◽  
Nadira Musallam ◽  
Meital Almog ◽  
Ellen Bamberger ◽  
...  

2005 ◽  
Vol 64 (4) ◽  
pp. 413-417 ◽  
Author(s):  
Charlotte Madsen

At present the only cure for food allergy is to avoid eating the food responsible for the allergy. Thus, food allergy or food hypersensitivity is a disease that is not only of concern to the individual who is affected but also to those involved directly and indirectly in supplying andpreparing food for the food-allergic individual, and its impact on society should be evaluated on this basis. It is generally assumed that questionnaire-based studies vastly overestimate the prevalence of food hypersensitivity. The reported perceived prevalence of food hypersensitivity varies from 3.24% to 34.9%, which may be explained partly by the difference in reporting lifetime prevalence compared with point prevalence. However, of more importance is the apparent inverse correlation between response rate and prevalence (the higher the response rate, the lower the perceived prevalence). The three most-recent prevalence studies on food hypersensitivity (one on perceived food hypersensitivity and two on confirmed food hypersensitivity) all report estimates for prevalence of approximately 3%, but their criteria for including subjects as being positive are not identical, although they do overlap. Furthermore, because of differences in methodology there is no definitive information to indicate whether the prevalence of food allergy is increasing. However, the high prevalence of pollen-related food allergy in younger adults in the population suggests that the increase in pollen allergy is also being accompanied by an increase in pollen-related food allergy.


2015 ◽  
Vol 3 (2) ◽  
pp. 291-293.e2 ◽  
Author(s):  
Lianne Soller ◽  
Moshe Ben-Shoshan ◽  
Daniel W. Harrington ◽  
Megan Knoll ◽  
Joseph Fragapane ◽  
...  

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