Drug Allergy Delabeling Programs: Recent Strategies and Targeted Populations

2022 ◽  
Author(s):  
Karen M. Anstey ◽  
Lulu Tsao ◽  
Iris M. Otani
Keyword(s):  
Drug Allergy

Keeping up with drug allergy

1996 ◽  
Vol 26 (12) ◽  
pp. 1341-1342 ◽  
Author(s):  
J. W. Coleman
Keyword(s):  
Drug Allergy

Diagnostic methods for confirming drug-allergy – the lymphocyte transformation test in dermatology

2008 ◽  
Vol 149 (24) ◽  
pp. 1107-1114
Author(s):  
Sarolta Makó ◽  
Réka Lepesi-Benkő ◽  
Márta Marschalkó ◽  
Gyöngyvér Soós ◽  
Sarolta Kárpáti
Keyword(s):  
Drug Allergy ◽  
Lymphocyte Transformation ◽  
Lymphocyte Transformation Test ◽  
Diagnostic Methods

A gyógyszermellékhatások felismerése és a tüneteket kiváltó gyógyszer oki szerepének bizonyítása komoly felkészültséget igényel. E közlemény célja a gyógyszerallergiás reakciók diagnosztikai lehetőségeinek rövid áttekintése és a lymphocytatranszformációs teszt gyógyszer-hiperszenzitivitási reakciókban való bizonyító szerepének bőrgyógyászati szempontok szerinti értékelése. A lymphocytatranszformációs teszt azon a megfigyelésen alapul, hogy a gyógyszerrel való első találkozáskor kialakult antigénspecifikus T-sejtek osztódni kezdenek az antigénnel való in vitro megismételt találkozás után. A szenzibilizációt az osztódó T-sejtekbe történő 3 H-timidin-beépülés mértéke jelzi. A hatóanyag-specifikus T-sejtek szinte mindig részt vesznek a gyógyszerallergiás reakciókban, ezért a vizsgálat előnye, hogy sok gyógyszernél és különböző immunreakciók eseteiben egyaránt jól alkalmazható. Hátránya a munkaigényesség, valamint az, hogy specificitásának és szenzitivitásának bizonyításához hiányoznak a széles körű, nagy beteganyagon elvégzett tanulmányok. Emiatt a teszt nem egyértelműen elfogadott a gyógyszerallergia igazolására. Hiányosságai ellenére azonban, jobb prediktív értékű egyéb vizsgálatok hiányában, a lymphocytatranszformációs tesztnek fontos szerepe van a gyógyszerallergiák diagnosztizálása terén.

Dendrimer-Modified Solid Supports: Nanostructured Materials with Potential Drug Allergy Diagnostic Applications

2012 ◽  
Vol 19 (29) ◽  
pp. 4942-4954 ◽  
Author(s):  
A. J. Ruiz-Sanchez ◽  
M. I. Montanez ◽  
C. Mayorga ◽  
M. J. Torres ◽  
N. S. Kehr ◽  
...  
Keyword(s):  
Nanostructured Materials ◽  
Drug Allergy ◽  
Potential Drug ◽  
Solid Supports ◽  
Diagnostic Applications

Direct challenges for delabeling drug allergy in pediatric patients

2021 ◽  
Vol 147 (2) ◽  
pp. AB10
Author(s):  
Sara Concha ◽  
Josefina Castagnoli ◽  
Florencia Neumann ◽  
Arturo Borzutzky ◽  
Rodrigo Hoyos
Keyword(s):  
Drug Allergy ◽  
Pediatric Patients

scholarly journals 1338. Analysis of Prescription Guideline Adherence in Pediatric Outpatient Pneumonia Treatment

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S680-S681
Author(s):  
Carly Heck ◽  
Judith Martin ◽  
Marcia Kurs-Lasky
Keyword(s):  
Drug Allergy ◽  
Health Concern ◽  
Second Line ◽  
First Line ◽  
Second Line Therapy ◽  
First Line Therapy ◽  
Line Therapy ◽  
Comparison Results ◽  
Significant Difference ◽  
Recommended Therapy

Abstract Background Background: Antibiotic resistance is a major public health concern. A modifiable intervention is outpatient antibiotic stewardship. The goal of this study was to review the electronic health records (EHR) of children diagnosed with community acquired pneumonia (CAP) to compare patients who received non-guideline concordant therapy with those prescribed recommended therapy. Methods Methods: This was a retrospective chart review of 300 children (6 months to 6 years old) with an outpatient diagnosis of CAP between July 2017 and June 2019. 45 Children’s Hospital of Pittsburgh (CHP) and UPMC Children’s Community Pediatrics (CCP) practices were included. CHP practices are academic-based with trainees involved in visits, while CCP practices do not include trainees. First-line recommended therapy was defined as amoxicillin, second-line therapy as azithromycin or amoxicillin-clavulanate, and all other prescriptions were defined as other. Patients prescribed first-line therapy were compared to patients with second-line therapy or other. If first-line therapy was not prescribed, the EHR was manually reviewed for justification. If drug allergy was listed, the medication allergy and type of reaction were recorded. Results Results: In this study the minority of children (43%) were prescribed first-line therapy. This group was younger (57 vs. 63 months of age), more likely to be Non-white (80%), and seen at the CHP locations than those prescribed non-guideline concordant therapy. The average symptom duration was shorter, heart rate and respiratory rate were higher and the presence of fever was more common in the first-line therapy group. Justification for non-guideline therapy was most often reported as to provide coverage for atypical organisms. The most common drug allergy recorded was amoxicillin, and urticaria with unknown timing was the most common type of reaction. Demographics Comparison Results Justification for Second-line / Other Therapy and Drug Allergy Results Conclusion This project observed a high proportion of children being prescribed non-guideline concordant therapy for a diagnosis of CAP. Age, race, practice location, and severity of illness measures showed a statistically significant difference between groups. This study highlights the importance of education which reviews the current guidelines and the most likely pathogens for children with CAP. Disclosures All Authors: No reported disclosures

Drug Allergy Labels Lost In Translation: From Patient to Charts and Backwards

2021 ◽  
Author(s):  
Allison Ramsey ◽  
Eric Macy ◽  
Anca-Mirela Chiriac ◽  
Kimberly G. Blumenthal
Keyword(s):  
Drug Allergy ◽  
Lost In Translation

Macrogol hypersensitivity in multiple drug allergy

2011 ◽  
Vol 107 (6) ◽  
pp. 542-543 ◽  
Author(s):  
Luisa Bommarito ◽  
Sabrina Mietta ◽  
Franco Nebiolo ◽  
Massimo Geuna ◽  
Giovanni Rolla
Keyword(s):  
Drug Allergy ◽  
Multiple Drug ◽  
Multiple Drug Allergy

scholarly journals Important questions in Allergy: 1 - drug allergy/hypersensitivity

Allergy ◽  
2008 ◽  
Vol 63 (5) ◽  
pp. 616-619 ◽  
Author(s):  
P. Demoly ◽  
W. Pichler ◽  
M. Pirmohamed ◽  
A. Romano
Keyword(s):  
Drug Allergy
Sign in / Sign up

Export Citation Format

Share Document