Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a

Endocrine ◽  
2017 ◽  
Vol 56 (1) ◽  
pp. 98-108 ◽  
Author(s):  
Wei Qiang ◽  
Fang Sui ◽  
Jingjing Ma ◽  
Xinru Li ◽  
Xiaojuan Ren ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Thyroid Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Proteasome Inhibitor ◽  
Proteasome Inhibitor Mg132 ◽  
Thyroid Cancer Cell ◽  
Cancer Cell Apoptosis

Targeting RET to induce medullary thyroid cancer cell apoptosis: an antagonistic interplay between PI3K/Akt and p38MAPK/caspase-8 pathways

APOPTOSIS ◽  
2013 ◽  
Vol 18 (5) ◽  
pp. 589-604 ◽  
Author(s):  
Minakshi Mazumdar ◽  
Arghya Adhikary ◽  
Samik Chakraborty ◽  
Shravanti Mukherjee ◽  
Argha Manna ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Medullary Thyroid Cancer ◽  
Caspase 8 ◽  
Thyroid Cancer Cell ◽  
Medullary Thyroid ◽  
Cancer Cell Apoptosis

scholarly journals Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways

2014 ◽  
Vol 5 (3) ◽  
pp. e1104-e1104 ◽  
Author(s):  
V Gunda ◽  
O Bucur ◽  
J Varnau ◽  
P Vanden Borre ◽  
M J Bernasconi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Thyroid Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Induction of Thyroid Cancer Cell Apoptosis by a Novel Nuclear Factor κB Inhibitor, Dehydroxymethylepoxyquinomicin

2004 ◽  
Vol 10 (20) ◽  
pp. 6821-6829 ◽  
Author(s):  
Dmitriy V. Starenki ◽  
Hiroyuki Namba ◽  
Vladimir A. Saenko ◽  
Akira Ohtsuru ◽  
Shigeto Maeda ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Thyroid Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Anticancer Effects of Cyclocarya paliurus Polysaccharide (CPP) on Thyroid Carcinoma In Vitro and In Vivo

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Zhiwei He ◽  
Fangfang Lv ◽  
Yueli Gan ◽  
Jing Gu ◽  
Ting Que
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cell ◽  
Western Blotting ◽  
Cell Apoptosis ◽  
Cancer Cell Line ◽  
B Cell Lymphoma ◽  
Thyroid Cancer Cell ◽  
Cyclocarya Paliurus

In this study, we explored the role and mechanisms of Cyclocarya paliurus polysaccharide on cell apoptosis in thyroid cancer (TC) cells. The apoptosis of thyroid cancer cells in vitro and tumor tissues in vivo induced by Cyclocarya paliurus polysaccharide was determined by MTT assay and flow cytometric assay. The downstream molecules including phosphop-protein kinase B (p-Akt), Akt, B-cell lymphoma 2 (Bcl-2), and Bcl-2-associated X protein (Bax) in tumor tissue were evaluated by western blotting. MTT and flow cytometry assay in vitro revealed Cyclocarya paliurus polysaccharide-induced apoptosis of thyroid cancer cell line in a manner of time-dependent and dose-dependent. In vivo assay showed 50 mg/kg and 100 mg/kg Cyclocarya paliurus polysaccharide significantly suppressed the proliferation of thyroid cancer in mice. Western blotting showed downregulation of p-Akt, Akt, and Bcl-2 and upregulation of Bax. These results suggest that Cyclocarya paliurus polysaccharide may enhance thyroid cancer cell apoptosis by suppressing the activation of p-Akt, Akt, and Bcl-2 and activating Bax, which provide a novel use of CPP as a thyroid cancer treatment.

Influence of AUF1 targeting siRNA on cell cycle-related proteins in thyroid cancer cell lines

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
B Trojanowicz ◽  
Z Chen ◽  
J Bialek ◽  
Y Radestock ◽  
S Hombach-Klonisch ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Thyroid Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Thyroid Cancer Cell ◽  
Thyroid Cancer Cell Lines ◽  
Related Proteins
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