Bone and body composition analyses by DXA in adults with GH deficiency: effects of long-term replacement therapy

Endocrine ◽  
2021 ◽  
Author(s):  
Alessandro Rossini ◽  
Roberto Lanzi ◽  
Carlotta Galeone ◽  
Claudio Pelucchi ◽  
Mario Pennacchioni ◽  
...  
Keyword(s):  
Body Composition ◽  
Replacement Therapy ◽  
Gh Deficiency

scholarly journals Bone and Body Composition Analyses by Dxa in Adults With Gh Deficiency: Effects of Long-term Replacement Therapy

2021 ◽  
Author(s):  
Alessandro Rossini ◽  
Roberto Lanzi ◽  
Carlotta Galeone ◽  
Claudio Pelucchi ◽  
Mario Pennacchioni ◽  
...  
Keyword(s):  
Body Composition ◽  
Lumbar Spine ◽  
Bone Mass ◽  
Replacement Therapy ◽  
Gh Deficiency ◽  
Response To Treatment ◽  
Long Term Effects ◽  
Mineral Density ◽  
The Impact

Abstract Purpose: The effects of growth hormone (GH) replacement on bone mass and body composition in adult with GH deficiency (AGHD) are still debated with regard to their persistence in the long term. Moreover, the impact of gender on the response to GH is controversial. Aim of this study was to evaluate the long-term effects of rhGH replacement on bone mass and body composition in a monocentric cohort of patients with AGHD.Methods: Data from 138 patients with AGHD (34.3 ± 14.3 years, 48 women and 90 men) treated with rhGH for a period of at least 3 years up to a maximum of 10 were retrospectively collected. Bone mineral density (BMD) at the lumbar spine, femur, and radius, and total and truncular body composition were evaluated by dual energy X-ray absorption (DXA) before and during treatment. Clinical and laboratory evaluations were performed before and during the treatment period on an annual basis.Results: Lumbar spine BMD consistently increased in males, while in females decreased after a transient improvement observed during the first 4 years of therapy. There were no significant changes in femoral BMD in either sexes, while a progressive increase at radius was observed only in males. Lean mass significantly increased in both sexes, while fat mass decreased only in males.Conclusions: In AGHD patients long-term rhGH replacement therapy induces a positive effect with regard to bone mass and body composition. A sexual dimorphism in the response to treatment is evident, with males displaying more favorable outcome.

scholarly journals Long-Term Effect of Growth Hormone (GH) Treatment on Body Composition in Children with GH Deficiency

1999 ◽  
Vol 46 (Suppl) ◽  
pp. S35-S38 ◽  
Author(s):  
RYUICHI KUROMARU ◽  
HITOSHI KOHNO ◽  
NAMI UEYAMA ◽  
HASSAN MOHAMED SALAMA HASSAN ◽  
SUNAO HONDA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Gh Deficiency ◽  
Term Effect ◽  
Gh Treatment ◽  
Long Term Effect

Long-term effects of GH replacement therapy on thyroid function in children with GH deficiency

2019 ◽  
Author(s):  
Ida D'Acunzo ◽  
Federica Anselmi ◽  
Valeria Gaeta ◽  
Flavia Barbieri ◽  
Gian Paolo Ciccarelli ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Thyroid Function ◽  
Gh Deficiency ◽  
Long Term Effects ◽  
Gh Replacement

scholarly journals Significant GH deficiency after long-term cure by surgery in adult patients with Cushing’s disease

2007 ◽  
Vol 156 (2) ◽  
pp. 233-239 ◽  
Author(s):  
Francesca Pecori Giraldi ◽  
Massimiliano Andrioli ◽  
Laura De Marinis ◽  
Antonio Bianchi ◽  
Antonella Giampietro ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Cushing’S Disease ◽  
Gh Deficiency ◽  
Pituitary Surgery ◽  
Male Gender ◽  
Cushing's Disease ◽  
Gh Secretion ◽  
Wide Variability ◽  
Acth Secreting

Objective: Impaired GH secretion usually accompanies Cushing’s syndrome and a variable proportion of patients reportedly fail to recover normal GH secretion after successful treatment. This wide variability is most probably due to differences in the treatment (i.e. surgery and/or radiotherapy), timing of patient re-evaluation after surgery and dynamic tests employed to challenge GH secretion, and hinders a precise assessment of risk of GH deficiency after cure. The aim of the present study is to evaluate GH secretory status after long-term cure of Cushing’s disease achieved by surgery alone. Design and methods: We studied 34 patients (27 females and 7 males, age range 21–68 years) formerly affected by Cushing’s disease. Patients were studied 2–20 years (median 3.3 years) following remission of hypercortisolism; all patients underwent transsphenoidal surgery with the removal of an ACTH-secreting adenoma; repeat pituitary surgery for relapse was performed in two patients while bilateral adrenalectomy was necessary in two patients. In all subjects, the GH response to GHRH+arginine stimulation was evaluated. At the time of testing, 13 patients were still on steroid replacement therapy. Results: In long-term surgical remission, 22 patients (65.0%) presented subnormal GH secretion; partial GH deficiency (GH peak <16.5 μg/l) was found in 11 patients and severe GH deficiency (GH peak <9 μg/l) in another 11. Male gender and length of hypercortisolism were risk factors for postsurgical GH deficiency. Conclusions: This study demonstrates the presence of GH deficiency in a high percentage of patients with Cushing’s disease after long-term remission of hypercortisolism obtained by surgery alone. Male gender and length of hypercortisolism are the most significant predictors of postsurgical GH deficiency. This finding is significant as it highlights that even the most favourable therapeutical course, i.e. remission achieved by surgery alone, is accompanied by impaired GH secretion. Assessment of GH secretion is therefore recommended for all patients cured from Cushing’s disease, even if not submitted to radiotherapy. Studies on the clinical impact of GH deficiency and the use of GH replacement therapy seem warranted in patients cured from Cushing’s disease.

Sign in / Sign up

Export Citation Format

Share Document