scholarly journals Innate immunity in the pathogenesis of polytropic retrovirus infection in the central nervous system

2008 ◽  
Vol 43 (1-3) ◽  
pp. 149-159 ◽  
Author(s):  
Karin E. Peterson ◽  
Min Du
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
The Central Nervous System ◽  
Retrovirus Infection

scholarly journals Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?

2019 ◽  
Vol 10 ◽  
Author(s):  
Robb Wesselingh ◽  
Helmut Butzkueven ◽  
Katherine Buzzard ◽  
David Tarlinton ◽  
Terence J. O'Brien ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
Autoimmune Encephalitis ◽  
System A ◽  
The Central Nervous System

scholarly journals Targeting innate immunity for neurodegenerative disorders of the central nervous system

2016 ◽  
Vol 138 (5) ◽  
pp. 653-693 ◽  
Author(s):  
Katrin I. Andreasson ◽  
Adam D. Bachstetter ◽  
Marco Colonna ◽  
Florent Ginhoux ◽  
Clive Holmes ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
Neurodegenerative Disorders ◽  
The Central Nervous System

scholarly journals HIV life cycle, innate immunity and autophagy in the central nervous system

2014 ◽  
Vol 9 (6) ◽  
pp. 565-571 ◽  
Author(s):  
Kelly A. Meulendyke ◽  
Joshua D. Croteau ◽  
M. Christine Zink
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
Life Cycle ◽  
The Central Nervous System

scholarly journals Modulation of the Complement System by Neoplastic Disease of the Central Nervous System

2021 ◽  
Vol 12 ◽  
Author(s):  
Steven K. Yarmoska ◽  
Ali M. Alawieh ◽  
Stephen Tomlinson ◽  
Kimberly B. Hoang
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
Adaptive Immunity ◽  
Complement System ◽  
Neoplastic Disease ◽  
Innate And Adaptive Immunity ◽  
Neoplastic Diseases ◽  
The Central Nervous System ◽  
The Complement System

The complement system is a highly conserved component of innate immunity that is involved in recognizing and responding to pathogens. The system serves as a bridge between innate and adaptive immunity, and modulation of the complement system can affect the entire host immune response to a foreign insult. Neoplastic diseases have been shown to engage the complement system in order to evade the immune system, gain a selective growth advantage, and co-opt the surrounding environment for tumor proliferation. Historically, the central nervous system has been considered to be an immune-privileged environment, but it is now clear that there are active roles for both innate and adaptive immunity within the central nervous system. Much of the research on the role of immunological modulation of neoplastic disease within the central nervous system has focused on adaptive immunity, even though innate immunity still plays a critical role in the natural history of central nervous system neoplasms. Here, we review the modulation of the complement system by a variety of neoplastic diseases of the central nervous system. We also discuss gaps in the current body of knowledge and comment on future directions for investigation.

scholarly journals Visna-Maedi-Like Disease Associated with an Ovine Retrovirus Infection in a Corriedale Sheep

1980 ◽  
Vol 17 (5) ◽  
pp. 544-552 ◽  
Author(s):  
W. D. Sheffield ◽  
O. Narayan ◽  
J. D. Strandberg ◽  
R. J. Adams
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Stem ◽  
Virus Replication ◽  
Lymphoid Hyperplasia ◽  
Cervical Cord ◽  
Pathologic Examination ◽  
The Central Nervous System ◽  
Retrovirus Infection ◽  
The Brain

A visna-maedi-like disease was found in a Corriedale sheep from which a retrovirus sharing the group antigen of visna-progressive pneumonia virus was isolated from lung, brain, and spleen. Clinically, the sheep had acute neurologic signs and dyspnea. Pathologic examination showed lesions similar to both visna and maedi. In the lung, there was a patchy interstitial pneumonia with marked lymphoid hyperplasia. Changes in the central nervous system were necrotizing nonsuppurative encephalitis of the brain stem, poliomyelitis of the cervical cord, and ependymitis and subependymal gliosis of the ventricles. Histologically, the central nervous system lesions seemed to have arisen sequentially, perhaps in response to bursts of virus replication as the agent underwent possible antigenic mutation. The severe lesions in both the central nervous system and lungs suggested a virus strain with dual tropism.

scholarly journals Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll‐Like Receptor (TLR) 2 and TLR4

2008 ◽  
Vol 198 (7) ◽  
pp. 1028-1036 ◽  
Author(s):  
Matthias Klein ◽  
Bianca Obermaier ◽  
Barbara Angele ◽  
Hans‐Walter Pfister ◽  
Hermann Wagner ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
Pneumococcal Infection ◽  
Toll Like Receptor ◽  
The Central Nervous System

scholarly journals Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination

2010 ◽  
Vol 120 (2) ◽  
pp. 223-236 ◽  
Author(s):  
Rakhi Sharma ◽  
Marie-Therese Fischer ◽  
Jan Bauer ◽  
Paul A. Felts ◽  
Kenneth J. Smith ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
Primary Astrocyte ◽  
The Central Nervous System

scholarly journals Innate immunity in the central nervous system

2012 ◽  
Vol 122 (4) ◽  
pp. 1164-1171 ◽  
Author(s):  
Richard M. Ransohoff ◽  
Melissa A. Brown
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
The Central Nervous System

HIV-infection of the central nervous system: the tightrope walk of innate immunity

2005 ◽  
Vol 42 (2) ◽  
pp. 213-228 ◽  
Author(s):  
Cornelia Speth ◽  
Manfred P. Dierich ◽  
Sieghart Sopper
Keyword(s):  
Central Nervous System ◽  
Innate Immunity ◽  
Nervous System ◽  
Hiv Infection ◽  
The Central Nervous System
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