Cellular Prion Protein Participates in the Regulation of Inflammatory Response and Apoptosis in BV2 Microglia During Infection with Mycobacterium bovis

2013 ◽  
Vol 51 (1) ◽  
pp. 118-126 ◽  
Author(s):  
Tianjian Ding ◽  
Xiangmei Zhou ◽  
Mohammed Kouadir ◽  
Fushan Shi ◽  
Yang Yang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Prion Protein ◽  
Mycobacterium Bovis ◽  
Cellular Prion Protein ◽  
Bv2 Microglia

scholarly journals The cellular prion protein modulates phagocytosis and inflammatory response

2004 ◽  
Vol 77 (2) ◽  
pp. 238-246 ◽  
Author(s):  
Cecília J. G. de Almeida ◽  
Luciana B. Chiarini ◽  
Juliane Pereira da Silva ◽  
Patrícia M. R. e Silva ◽  
Marco Aurélio Martins ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Prion Protein ◽  
Cellular Prion Protein

scholarly journals Pharmacological inactivation of the prion protein by targeting a folding intermediate

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Giovanni Spagnolli ◽  
Tania Massignan ◽  
Andrea Astolfi ◽  
Silvia Biggi ◽  
Marta Rigoli ◽  
...  
Keyword(s):  
Prion Protein ◽  
Prion Diseases ◽  
Cellular Prion Protein ◽  
Surface Glycoprotein ◽  
Folding Intermediate ◽  
Biological Regulation ◽  
Cell Surface Glycoprotein ◽  
Folding Intermediates ◽  
Protein Levels ◽  
Small Molecule Ligands

AbstractRecent computational advancements in the simulation of biochemical processes allow investigating the mechanisms involved in protein regulation with realistic physics-based models, at an atomistic level of resolution. These techniques allowed us to design a drug discovery approach, named Pharmacological Protein Inactivation by Folding Intermediate Targeting (PPI-FIT), based on the rationale of negatively regulating protein levels by targeting folding intermediates. Here, PPI-FIT was tested for the first time on the cellular prion protein (PrP), a cell surface glycoprotein playing a key role in fatal and transmissible neurodegenerative pathologies known as prion diseases. We predicted the all-atom structure of an intermediate appearing along the folding pathway of PrP and identified four different small molecule ligands for this conformer, all capable of selectively lowering the load of the protein by promoting its degradation. Our data support the notion that the level of target proteins could be modulated by acting on their folding pathways, implying a previously unappreciated role for folding intermediates in the biological regulation of protein expression.

Peptide NMHRYPNQ of the Cellular Prion Protein (PrPC) Inhibits Aggregation and Is a Potential Key for Understanding Prion–Prion Interactions

2009 ◽  
Vol 392 (1) ◽  
pp. 198-207 ◽  
Author(s):  
Dirk Rehders ◽  
Birgit Claasen ◽  
Lars Redecke ◽  
Alexander Buschke ◽  
Caroline Reibe ◽  
...  
Keyword(s):  
Prion Protein ◽  
Cellular Prion Protein

scholarly journals Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis

2021 ◽  
pp. 100117
Author(s):  
Flora Martinez Figueira Moreira ◽  
Joyce Alencar Santos Radai ◽  
Vanessa Vilamaior de Souza ◽  
Claudia Rodrigues Berno ◽  
Flavio Henrique Souza de Araújo ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Mycobacterium Bovis ◽  
Toxicological Analysis

Prion protein participates in the regulation of classical and alternative activation of BV2 microglia

2012 ◽  
Vol 124 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Fushan Shi ◽  
Lifeng Yang ◽  
Mohammed Kouadir ◽  
Yang Yang ◽  
Tianjian Ding ◽  
...  
Keyword(s):  
Prion Protein ◽  
Alternative Activation ◽  
Bv2 Microglia
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