Streptozotocin Intracerebroventricular-Induced Neurotoxicity and Brain Insulin Resistance: a Therapeutic Intervention for Treatment of Sporadic Alzheimer’s Disease (sAD)-Like Pathology

2015 ◽  
Vol 53 (7) ◽  
pp. 4548-4562 ◽  
Author(s):  
Pradip K. Kamat ◽  
Anuradha Kalani ◽  
Shivika Rai ◽  
Santosh Kumar Tota ◽  
Ashok Kumar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Therapeutic Intervention ◽  
Sporadic Alzheimer’S Disease ◽  
Brain Insulin ◽  
Brain Insulin Resistance

P2-107: Brain Insulin Resistance and Alzheimer's Disease Neuropathology Among Older Autopsied Persons With and Without Diabetes

2016 ◽  
Vol 12 ◽  
pp. P653-P653
Author(s):  
Rexford S. Ahima ◽  
Ana W. Capuano ◽  
Julie A. Schneider ◽  
David A. Bennett ◽  
Steven E. Arnold ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Brain Insulin ◽  
Brain Insulin Resistance

scholarly journals Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Tomoko Wakabayashi ◽  
Kazuki Yamaguchi ◽  
Kentaro Matsui ◽  
Toshiharu Sano ◽  
Tetsuya Kubota ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Differential Effects ◽  
Amyloid Pathology ◽  
Brain Insulin ◽  
Model Of Alzheimer’S Disease ◽  
Brain Insulin Resistance

scholarly journals Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

2017 ◽  
Vol 38 (4) ◽  
pp. 1933-1940 ◽  
Author(s):  
Roger J. Mullins ◽  
Maja Mustapic ◽  
Edward J. Goetzl ◽  
Dimitrios Kapogiannis
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Brain Insulin ◽  
Brain Insulin Resistance

scholarly journals Broadening the definition of brain insulin resistance in aging and Alzheimer's disease

2019 ◽  
Vol 313 ◽  
pp. 79-87 ◽  
Author(s):  
Hilaree N. Frazier ◽  
Adam O. Ghoweri ◽  
Katie L. Anderson ◽  
Ruei-Lung Lin ◽  
Nada M. Porter ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Brain Insulin ◽  
Definition Of ◽  
Brain Insulin Resistance

scholarly journals Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer

2019 ◽  
Vol 67 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Mehmet Murat Koseoglu ◽  
Andrés Norambuena ◽  
Elizabeth R. Sharlow ◽  
John S. Lazo ◽  
George S. Bloom
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Cell Cycle ◽  
Alzheimer's Disease ◽  
Neuronal Cell ◽  
Brain Insulin ◽  
Brain Insulin Resistance

O4-02-01: Brain insulin resistance demonstrated in Alzheimer's disease is closely associated with elevated IRS-1 pS and cognitive deficits

2011 ◽  
Vol 7 ◽  
pp. S683-S683 ◽  
Author(s):  
Konrad Talbot ◽  
Hoau-Yan Wang ◽  
Hala Kazi ◽  
Li-Ying Han ◽  
Kalindi Bakshi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Brain Insulin ◽  
Brain Insulin Resistance

scholarly journals Dysregulation of Insulin-Linked Metabolic Pathways in Alzheimer’s Disease: Co-Factor Role of Apolipoprotein E ɛ4

2020 ◽  
Vol 4 (1) ◽  
pp. 479-493
Author(s):  
James Robbins ◽  
Oriol Busquets ◽  
Ming Tong ◽  
Suzanne M. de la Monte
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Enzyme Linked Immunosorbent Assay ◽  
Potential Contribution ◽  
Braak Stage ◽  
Brain Insulin ◽  
Brain Insulin Resistance ◽  
The Impact

Background: Brain insulin resistance and deficiency are well-recognized abnormalities in Alzheimer’s disease (AD) and likely mediators of impaired energy metabolism. Since apolipoprotein E (APOE) is a major risk factor for late-onset AD, it was of interest to examine its potential contribution to altered insulin-linked signaling networks in the brain. Objective: The main goal was to evaluate the independent and interactive contributions of AD severity and APOE ɛ4 dose on brain expression of insulin-related polypeptides and inflammatory mediators of metabolic dysfunction. Methods: Postmortem fresh frozen frontal lobe tissue from banked cases with known APOE genotypes and different AD Braak stages were used to measure insulin network polypeptide immunoreactivity with a commercial multiplex enzyme-linked immunosorbent assay (ELISA). Results: Significant AD Braak stage and APOE genotype-related abnormalities in insulin, C-peptide, gastric inhibitory polypeptide (GIP), glucaton-like peptide-1 (GLP-1), leptin, ghrelin, glucagon, resistin, and plasminogen activator inhibitor-1 (PAI-1) were detected. The main factors inhibiting polypeptide expression and promoting neuro-inflammatory responses included AD Braak stage and APOE ɛ4/ɛ4 rather than ɛ3/ɛ4. Conclusion: This study demonstrates an expanded role for impaired expression of insulin-related network polypeptides as well as neuroinflammatory mediators of brain insulin resistance in AD pathogenesis and progression. In addition, the findings show that APOE has independent and additive effects on these aberrations in brain polypeptide expression, but the impact is decidedly greater for APOE ɛ4/ɛ4 than ɛ3/ɛ4.

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