Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers

2017 ◽  
Vol 55 (3) ◽  
pp. 2174-2184 ◽  
Author(s):  
Zhihui Yang ◽  
Helen M. Bramlett ◽  
Ahmed Moghieb ◽  
Dongnan Yu ◽  
Ping Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Spinal Cord ◽  
Protein Biomarkers ◽  
Temporal Profile ◽  
Cord Injury

The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats

1994 ◽  
Vol 80 (1) ◽  
pp. 97-111 ◽  
Author(s):  
Shlomo Constantini ◽  
Wise Young
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Body Weight Loss ◽  
Ganglioside Gm1 ◽  
Rat Spinal Cord ◽  
Neuroprotective Effects ◽  
Content Type ◽  
Human Spinal Cord ◽  
Cord Injury ◽  
Fine Print

✓ Recent clinical trials have reported that methylprednisolone sodium succinate (MP) or the monosialic ganglioside GM1 improves neurological recovery in human spinal cord injury. Because GM1 may have additive or synergistic effects when used with MP, the authors compared MP, GM1, and MP+GM1 treatments in a graded rat spinal cord contusion model. Spinal cord injury was caused by dropping a rod weighing 10 gm from a height of 1.25, 2.5, or 5.0 cm onto the rat spinal cord at T-10, which had been exposed via laminectomy. The lesion volumes were quantified from spinal cord Na and K shifts at 24 hours after injury and the results were verified histologically in separate experiments. A single dose of MP (30 mg/kg), given 5 minutes after injury, reduced 24-hour spinal cord lesion volumes by 56% (p = 0.0052), 28% (p = 0.0065), and 13% (p > 0.05) in the three injury-severity groups, respectively, compared to similarly injured control groups treated with vehicle only. Methylprednisolone also prevented injury-induced hyponatremia and increased body weight loss in the spine-injured rats. When used alone, GM1 (10 to 30 mg/kg) had little or no effect on any measured variable compared to vehicle controls; when given concomitantly with MP, GM1 blocked the neuroprotective effects of MP. At a dose of 3 mg/kg, GM1 partially prevented MP-induced reductions in lesion volumes, while 10 to 30 mg/kg of GM1 completely blocked these effects of MP. The effects of MP on injury-induced hyponatremia and body weight loss were also blocked by GM1. Thus, GM1 antagonized both central and peripheral effects of MP in spine-injured rats. Until this interaction is clarified, the authors recommend that MP and GM1 not be used concomitantly to treat acute human spinal cord injury. Because GM1 modulates protein kinase activity, protein kinases inhibit lipocortins, and lipocortins mediate anti-inflammatory effects of glucocorticoids, it is proposed that the neuroprotective effects of MP are partially due to anti-inflammatory effects and that GM1 antagonizes the effects of MP by inhibiting lipocortin. Possible beneficial effects of GM1 reported in central nervous system injury may be related to the effects on neural recovery rather than acute injury processes.

Up-regulation of TRAF2 Suppresses Neuronal Apoptosis after Rat Spinal Cord Injury

2017 ◽  
Vol 49 (5) ◽  
pp. 589-596 ◽  
Author(s):  
Guanhua Xu ◽  
Jinlong Zhang ◽  
Lingling Wang ◽  
Zhiming Cui ◽  
Xu Sun ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Apoptosis ◽  
Rat Spinal Cord ◽  
Cord Injury

scholarly journals Synergistic Effect of Neural Stem Cells and Olfactory Ensheathing Cells on Repair of Adult Rat Spinal Cord Injury

2010 ◽  
Vol 19 (10) ◽  
pp. 1325-1337 ◽  
Author(s):  
Gan Wang ◽  
Qiang Ao ◽  
Kai Gong ◽  
Huancong Zuo ◽  
Yandao Gong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Synergistic Effect ◽  
Neural Stem Cells ◽  
Olfactory Ensheathing Cells ◽  
Rat Spinal Cord ◽  
Adult Rat ◽  
Cord Injury ◽  
Adult Rat Spinal Cord

Spatiotemporal patterns of postsynaptic density (PSD)-95 expression after rat spinal cord injury

2008 ◽  
Vol 34 (3) ◽  
pp. 340-356 ◽  
Author(s):  
C. Cheng ◽  
S. Gao ◽  
J. Zhao ◽  
S. Niu ◽  
M. Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Postsynaptic Density ◽  
Spatiotemporal Patterns ◽  
Rat Spinal Cord ◽  
Cord Injury

scholarly journals Improved rat spinal cord injury model using spinal cord compression by percutaneous method

2013 ◽  
Vol 14 (3) ◽  
pp. 329 ◽  
Author(s):  
Wook-Hun Chung ◽  
Jae-Hoon Lee ◽  
Dai-Jung Chung ◽  
Wo-Jong Yang ◽  
A-Jin Lee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Rat Spinal Cord ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

scholarly journals Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury

2022 ◽  
Vol 17 (7) ◽  
pp. 1505
Author(s):  
Riyi Shi ◽  
SethA Herr ◽  
Liangqin Shi ◽  
Thomas Gianaris ◽  
Yucheng Jiao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Aldehyde Dehydrogenase ◽  
Critical Role ◽  
Aldehyde Dehydrogenase 2 ◽  
Rat Spinal Cord ◽  
Cord Injury

Upregulation of PTP1B After Rat Spinal Cord Injury

Inflammation ◽  
2015 ◽  
Vol 38 (5) ◽  
pp. 1891-1902 ◽  
Author(s):  
Xinhui Zhu ◽  
Ying Zhou ◽  
Ran Tao ◽  
Jianmei Zhao ◽  
Jianping Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Spinal Cord ◽  
Cord Injury

scholarly journals Treatment of Rat Spinal Cord Injury with the Neurotrophic Factor Albumin-Oleic Acid: Translational Application for Paralysis, Spasticity and Pain

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e26107 ◽  
Author(s):  
Gerardo Avila-Martin ◽  
Iriana Galan-Arriero ◽  
Julio Gómez-Soriano ◽  
Julian Taylor
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Oleic Acid ◽  
Neurotrophic Factor ◽  
Rat Spinal Cord ◽  
Cord Injury

RBM5 and p53 expression after rat spinal cord injury: Implications for neuronal apoptosis

2015 ◽  
Vol 60 ◽  
pp. 43-52 ◽  
Author(s):  
Jinlong Zhang ◽  
Zhiming Cui ◽  
Guijuan Feng ◽  
Guofeng Bao ◽  
Guanhua Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Apoptosis ◽  
Rat Spinal Cord ◽  
P53 Expression ◽  
Cord Injury
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