Background: Cadmium is a ubiquitous environmental pollutant and has been associated with many adverse health outcomes. However, little is known about the effect of cadmium exposure on taste and smell dysfunction. Methods: We used the National Health and Nutrition Examination Survey (NHANES) 2011–2014 to investigate the associations between blood cadmium and taste and smell dysfunction among 5038 adults aged 40–80 years old. Taste and smell dysfunction were defined by questionnaires, examinations, or both criteria. Results: In survey weighted logistic regression models adjusting for age, gender, race/ethnicity, income-to-poverty ratio (IPR), and education, individuals with a blood cadmium level in the highest tertiles had significantly higher odds of having perceived smell dysfunction (odds ratio (OR) = 1.41, 95% confidence interval (CI): 1.08, 1.84), perceived taste dysfunction (OR = 1.48, 95% CI: 1.16, 1.89), and taste dysfunction defined by both self-reported and objectively measured data (OR = 1.46, 95% CI: 1.03, 2.07). After further adjusting for body mass index (BMI), cigarette smoking, and alcohol drinking, consistent results were observed for perceived taste dysfunction (OR = 1.49, 95% CI: 1.10, 2.00), and no significant associations were found between cadmium exposure and other outcomes. Conclusions: Our findings suggest that cadmium exposure is associated with perceived taste dysfunction.
The Taste and Smell Protocol in the 2011–2014 US National Health and Nutrition Examination Survey (NHANES): Test–Retest Reliability and Validity Testing
