99mTc-labeled peptide targeting interleukin 13 receptor α 2 for tumor imaging in a cervical cancer mouse model

2022 ◽  
Author(s):  
Yujing Du ◽  
Zhao Chen ◽  
Xiaojiang Duan ◽  
Ping Yan ◽  
Chunli Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Mouse Model ◽  
Tumor Imaging ◽  
Interleukin 13 ◽  
Peptide Targeting

Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention in a mouse model of cervical cancer

2008 ◽  
Vol 111 (2) ◽  
pp. 356-364 ◽  
Author(s):  
Amy L. Jonson ◽  
Lisa M. Rogers ◽  
Sundaram Ramakrishnan ◽  
Levi S. Downs
Keyword(s):  
Cervical Cancer ◽  
Mouse Model ◽  
Gene Silencing ◽  
Therapeutic Intervention

Functional roles of female sex hormones and their nuclear receptors in cervical cancer

2021 ◽  
Author(s):  
Seoung-Ae Lee ◽  
Seunghan Baik ◽  
Sang-Hyuk Chung
Keyword(s):  
Cervical Cancer ◽  
Mouse Model ◽  
Estrogen Receptor Α ◽  
Functional Roles ◽  
Genetic Ablation ◽  
Cervical Cancers ◽  
Female Sex Hormones ◽  
Exogenous Estrogen ◽  
Valuable Treatment ◽  
Hormone Sensitive

Abstract There has been little progress for several decades in modalities to treat cervical cancer. While the cervix is a hormone-sensitive tissue, physiologic roles of estrogen receptor α (ERα), progesterone receptor (PR), and their ligands in this tissue are poorly understood. It has hampered critical assessments of data in early epidemiologic and clinical studies for cervical cancer. Experimental evidence obtained from studies using mouse models has provided new insights into the molecular mechanism of ERα and PR in cervical cancer. In a mouse model expressing human papillomavirus (HPV) oncogenes, exogenous estrogen promotes cervical cancer through stromal ERα. In the same mouse model, genetic ablation of PR promotes cervical carcinogenesis without exogenous estrogen. Medroxyprogesterone acetate, a PR-activating drug, regresses cervical cancer in the mouse model. These results support that ERα and PR play opposite roles in cervical cancer. They further support that ERα inhibition and PR activation may be translated into valuable treatment for a subset of cervical cancers.

Human breast tumor imaging using 111In labeled monoclonal antibody: Athymic mouse model

1988 ◽  
Vol 14-14 (7-8) ◽  
Author(s):  
BanAn Khaw ◽  
JosephS. Bailes ◽  
SandraL. Schneider ◽  
Jack Lancaster ◽  
James Powers ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Mouse Model ◽  
Breast Tumor ◽  
Tumor Imaging ◽  
Athymic Mouse ◽  
Human Breast ◽  
Human Breast Tumor

scholarly journals Recombinant Lipidated HPV E7 Induces a Th-1-Biased Immune Response and Protective Immunity against Cervical Cancer in a Mouse Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40970 ◽  
Author(s):  
Chiung-Yi Huang ◽  
Jeremy J. W. Chen ◽  
Kuan-Yin Shen ◽  
Li-Sheng Chang ◽  
Yi-Chen Yeh ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Immune Response ◽  
Mouse Model ◽  
Protective Immunity ◽  
Hpv E7 ◽  
Th 1

scholarly journals Analysis of Biodistribution of Intracranially Infused Radiolabeled Interleukin-13 Receptor-Targeted Immunotoxin IL-13PE by SPECT/CT in an Orthotopic Mouse Model of Human Glioma

2014 ◽  
Vol 55 (8) ◽  
pp. 1323-1329 ◽  
Author(s):  
A. Suzuki ◽  
P. Leland ◽  
H. Kobayashi ◽  
P. L. Choyke ◽  
E. M. Jagoda ◽  
...  
Keyword(s):  
Mouse Model ◽  
Human Glioma ◽  
Orthotopic Mouse Model ◽  
Interleukin 13

Preclinical evaluation of 2-amino-2-[11C]methyl-butanoic acid as a potential tumor-imaging agent in a mouse model

2015 ◽  
Vol 36 (11) ◽  
pp. 1107-1112
Author(s):  
Chie Suzuki ◽  
Atsushi B. Tsuji ◽  
Koichi Kato ◽  
Hitomi Sudo ◽  
Ming-Rong Zhang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Imaging ◽  
Imaging Agent ◽  
Butanoic Acid ◽  
Preclinical Evaluation ◽  
Tumor Imaging Agent

scholarly journals IFNα-Expressing Amniotic Fluid-Derived Mesenchymal Stem Cells Migrate to and Suppress HeLa Cell-Derived Tumors in a Mouse Model

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Jun Zhou ◽  
Tian Liang ◽  
Dejun Wang ◽  
Liru Li ◽  
Yan Cheng ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Hela Cell ◽  
Amniotic Fluid ◽  
Genetically Modified ◽  
Tumor Tropism

Background. Immunotherapy for cervical cancer with type I interferon (IFN) is limited because of the cytotoxicity that accompanies the high doses that are administered. In this study, we investigated the utilization of amniotic fluid-derived mesenchymal stem cells (AF-MSCs) as a means for delivering IFNα to local tumor sites for the suppression of cervical cancer in a mouse model using HeLa cell xenografts. Methods. The tumor tropism ability of AF-MSCs and AF-MSCs genetically modified to overexpress IFNα (IFNα-AF-MSCs) was examined through Transwell in vitro and through fluorescent images and immunohistochemistry in a mouse model. Tumor size and tumor apoptosis were observed to evaluate the efficacy of the targeting therapy. Mechanistically, tumor cell apoptosis was detected by cytometry and TUNEL, and oncogenic proteins c-Myc, p53, and Bcl-2 as well as microvessel density were detected by immunohistochemistry. Results. In this model, intravenously injected AF-MSCs selectively migrated to the tumor sites, participated in tumor construction, and promoted tumor growth. After being genetically modified to overexpress IFNα, the IFNα-AF-MSCs maintained their tumor tropism but could significantly suppress tumor growth. The restrictive efficacy of IFNα-AF-MSCs was associated with the suppression of angiogenesis, inhibition of tumor cell proliferation, and induction of apoptosis in tumor cells. Neither AF-MSCs nor IFNα-AF-MSCs trigger tumor formation. Conclusions. IFNα-AF-MSC-based therapy is feasible and shows potential for treating cervical cancer, suggesting that AF-MSCs may be promising vehicles for delivering targeted anticancer therapy.

Abstract 4187: Expression of ion channels in a cervical cancer mouse model

2015 ◽  
Author(s):  
ANA RAMIREZ ◽  
EUNICE VERA ◽  
PAUL LAMBERT ◽  
PATRICIO GARIGLIO ◽  
JAVIER CAMACHO
Keyword(s):  
Cervical Cancer ◽  
Ion Channels ◽  
Mouse Model

Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma

2002 ◽  
Vol 32 (7) ◽  
pp. 1104-1111 ◽  
Author(s):  
R. K. Kumar ◽  
C. Herbert ◽  
M. Yang ◽  
A. M. L. Koskinen ◽  
A. N. J. McKenzie ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Remodelling ◽  
Chronic Asthma ◽  
Interleukin 13 ◽  
Eosinophil Accumulation
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