Wind turbine’s shrink disk (WTSD), as a component of transmission system, plays a crucial role in the wind turbine work. In this study, the matrix expression of combined pressure and interference magnitude has been derived by analyzing the geometry relationship of interference fit of multi-layer cylinder. The mechanic model is built by simplifying WTSD as interference fit of multi-layer cylinder. The reliability model is established on the basis of pressure-strength model, and the formula regarding reliability sensitivity is derived. In terms of the minimum principle on the square sum of reliability sensitivity and the minimum reliability principle, the reliability-based robust design (RBRD) model is built under the multi-objective conditions, and the dynamic reliability model is established on the basis of reliability model, load model, and residual strength model. Dynamic reliability sensitivity formula is deduced, and the dynamic reliability-based robust design (DRBRD) model is established under the multi-objective conditions. The effects of the coefficient of friction, assembly clearance, and yield strength on the reliability of WTSD are analyzed by RBRD and DRBRD methods. Taking a type of WTSD as an example, the calculating results validate that the reliability changes along with interference magnitude. The comparison of results shows that the above methods and Monte Carlo method have the same tendency and approximately agree well. Moreover, the traditional design method and RBRD method are compared. It turned out that RBRD can improve the reliability of WTSD by 47.6%, the reliability-based sensitivity is less than that from the traditional design method, and the robustness is stronger. The experiment verified that the design methods of this study can better meet the operation requirements.