First report of Candida bracarensis in Mexico: hydrolytic enzymes and antifungal susceptibility pattern

2018 ◽  
Vol 63 (4) ◽  
pp. 517-523 ◽  
Author(s):  
Rogelio de J. Treviño-Rangel ◽  
José F. Espinosa-Pérez ◽  
Hiram Villanueva-Lozano ◽  
Alexandra M. Montoya ◽  
Angel Andrade ◽  
...  
Keyword(s):  
Antifungal Susceptibility ◽  
Hydrolytic Enzymes ◽  
Susceptibility Pattern ◽  
First Report ◽  
Candida Bracarensis

A study on the antifungal susceptibility pattern of dermatophytes isolated in a tertiary care hospital

2017 ◽  
Vol 6 (05) ◽  
pp. 5379
Author(s):  
Vanathi Sabtharishi* ◽  
Radhika Katragadda ◽  
Thyagarajan Ravinder
Keyword(s):  
Tertiary Care Hospital ◽  
Antifungal Susceptibility ◽  
Tertiary Care ◽  
Antifungal Drugs ◽  
Dilution Method ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Superficial Mycosis ◽  
Broth Dilution ◽  
Common Infections

Recent years, due to increased usage of antifungal treatment worldwide, there is an increased chance of rising resistance among antifungal drugs too. Dermatophytic infections causes’ superficial mycosis and it affects skin, hair and nail. These infections are more common and antifungal drugs are used everywhere to treat those common infections. To conduct a study by determining the antifungal susceptibility pattern in dermatophytic isolates from patients attending dermatology OPD in a tertiary care hospital. A total of 217 samples like hair, nail and skin scrapings were obtained and isolation of dermatophytes was done. Antifungal susceptibility testing for dermatophytes was performed by micro broth dilution method. Antifungal drugs tested were Griseofulvin, Fluconazole, Itraconazole and Ketoconazole. Minimum inhibitory concentration for each drug for fungal isolates was tested and results studied. Fluconazole showed a higher MIC values in the range of 1-8µg/ml. Itraconazole showed the lowest MIC values by micro broth dilution method. Since there is limitation of standard guidelines and protocol, meticulous research must be conducted on effect of antifungals and derive at universally implementable guidelines.

scholarly journals Spectrum and theIn VitroAntifungal Susceptibility Pattern of Yeast Isolates in Ethiopian HIV Patients with Oropharyngeal Candidiasis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Birhan Moges ◽  
Adane Bitew ◽  
Aster Shewaamare
Keyword(s):  
Antifungal Agents ◽  
Antifungal Susceptibility ◽  
Antifungal Drugs ◽  
Assay Method ◽  
Cryptococcus Laurentii ◽  
Susceptibility Pattern ◽  
Test Procedures ◽  
Disk Diffusion Assay ◽  
Diffusion Assay

Background.In Ethiopia, little is known regarding the distribution and thein vitroantifungal susceptibility profile of yeasts.Objective.This study was undertaken to determine the spectrum and thein vitroantifungal susceptibility pattern of yeasts isolated from HIV infected patients with OPC.Method.Oral pharyngeal swabs taken from oral lesions of study subjects were inoculated onto Sabouraud Dextrose Agar. Yeasts were identified by employing conventional test procedures and the susceptibility of yeasts to antifungal agents was evaluated by disk diffusion assay method.Result.One hundred and fifty-five yeast isolates were recovered of which 91 isolates were from patients that were not under HAART and 64 were from patients that were under HAART.C. albicanswas the most frequently isolated species followed byC. glabrata, C. tropicalis, C. krusei, C. kefyr, Cryptococcus laurentii, and Rhodotorulaspecies. Irrespective of yeasts isolated and identified, 5.8%, 5.8%, 12.3%, 8.4%, 0.6%, and 1.3% of the isolates were resistant to amphotericin B, clotrimazole, fluconazole, ketoconazole, miconazole, and nystatin, respectively.Conclusion.Yeast colonization rate of 69.2% and 31% resistance to six antifungal agents was documented. These highlight the need for nationwide study on the epidemiology of OPC and resistance to antifungal drugs.

scholarly journals Study of oral candidiasis in HIV/AIDS patients and their antifungal susceptibility pattern

2019 ◽  
Vol 6 (4) ◽  
pp. 280-283
Author(s):  
Abhishek Singh ◽  
◽  
Sharon Victor ◽  
Asim Sarkar ◽  
Harapriya Kar ◽  
...  
Keyword(s):  
Oral Candidiasis ◽  
Antifungal Susceptibility ◽  
Susceptibility Pattern ◽  
Aids Patients ◽  
Hiv Aids

Effect of various ultraviolet radiation on antifungal susceptibility pattern and related genes expression in Malassezia sympodialis

Gene Reports ◽  
2019 ◽  
Vol 17 ◽  
pp. 100506
Author(s):  
Sanaz Aghaei Gharehbolagh ◽  
Zahra Salehi ◽  
Shahram Mahmoudi ◽  
Fatemeh Noorbakhsh ◽  
Sassan Rezaie
Keyword(s):  
Ultraviolet Radiation ◽  
Antifungal Susceptibility ◽  
Susceptibility Pattern ◽  
Genes Expression

scholarly journals Distribution, antifungal susceptibility pattern and intra-Candida albicans species complex prevalence of Candida africana: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237046 ◽  
Author(s):  
Sanaz Aghaei Gharehbolagh ◽  
Bahareh Fallah ◽  
Alireza Izadi ◽  
Zeinab Sadeghi Ardestani ◽  
Pooneh Malekifar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Candida Albicans ◽  
Species Complex ◽  
Meta Analysis ◽  
Antifungal Susceptibility ◽  
Susceptibility Pattern ◽  
Candida Africana

scholarly journals Antifungal Susceptibility Pattern of Non - Dermatophytic Fungi Causing Onychomycosis

2020 ◽  
Vol 18 (1) ◽  
pp. 28-36
Author(s):  
Apurva Kaushal ◽  
Pratik Gahalaut ◽  
R K Goyal ◽  
Neni Agarwal ◽  
Nitin Mishra ◽  
...  
Keyword(s):  
Candida Species ◽  
Plant Pathogens ◽  
Fusarium Species ◽  
Antifungal Susceptibility ◽  
Aspergillus Species ◽  
Dilution Method ◽  
Susceptibility Pattern ◽  
Cross Sectional ◽  
Anti Fungal

Introduction: Non-dermatophytic molds (NDM) are filamentous fungi or yeast, commonly found in nature as saprophytes and plant pathogens. The incidence of onychomycosis due to NDM is 1.45 – 16.6%. NDMs are usually resistant to conventional antifungal treatment. Objective: To know the anti-fungal susceptibility pattern of non-dermatophyte fungi causing onychomycosis.  Materials and Methods: A prospective hospital based cross-sectional study was done on non - dermatophytic isolates from patients with clinical suspicion of onychomycosis. All non – dermatophytic isolates were subjected to anti-fungal susceptibility against terbinafine, itraconazole, fluconazole and griseofulvin by micro broth dilution method.  Results: NDM were isolated in 20.2% cases of clinically suspected onychomycosis, among which Fusarium species was the most common followed by Aspergillus species and Candida species. MIC50 (Mean Inhibitory Concentration) for overall non - dermatophytic isolates for terbinafine, itraconazole, fluconazole and griseofulvin was 0.25μg/mL, 0.5μg/mL, 32μg/mL and 2μg/mL respectively and the order of sensitivity was Itraconazole (74.7%) > terbinafine (68%) > Fluconazole (60%) > Griseofulvin (51.6%) of the study samples. For Fusarium species, the  sensitivity for terbinafine was (73.5%) > itraconazole (67.6%) > fluconazole (64.7%) and griseofulvin (64.7%). For Aspergillus species, the sensitivity for itraconazole was 79.1% > fluconazole (58.3%) > terbinafine (54.1%) > griseofulvin (50%). For Candida species, the sensitivity was fluconazole (83.3%) > itraconazole (75%) > terbinafine (41.6%), while no candida species was found sensitive to griseofulvin.  Conclusion: Non-dermatophytes play a significant role in onychomycosis. On in vitro estimation, Itraconazole was the most sensitive drug, followed by terbinafine, fluconazole and griseofulvin.

scholarly journals Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains ofCandida glabrata

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Maria Helena Galdino Figueiredo-Carvalho ◽  
Lívia de Souza Ramos ◽  
Leonardo Silva Barbedo ◽  
Jean Carlos Almeida de Oliveira ◽  
André Luis Souza dos Santos ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Antifungal Susceptibility ◽  
Hydrolytic Enzymes ◽  
Antifungal Drug ◽  
Clinical Strains ◽  
Antifungal Drug Resistance ◽  
Opportunistic Fungal Pathogen ◽  
Esterase Production ◽  
In Vitro Antifungal Susceptibility

Candida glabratais a facultative intracellular opportunistic fungal pathogen in human infections. Several virulence-associated attributes are involved in its pathogenesis, host-pathogen interactions, modulation of host immune defenses, and regulation of antifungal drug resistance. This study evaluated the in vitro antifungal susceptibility profile to five antifungal agents, the production of seven hydrolytic enzymes related to virulence, and the relationship between these phenotypes in 91 clinical strains ofC. glabrata. AllC. glabratastrains were susceptible to flucytosine. However, some of these strains showed resistance to amphotericin B (9.9%), fluconazole (15.4%), itraconazole (5.5%), or micafungin (15.4%). Overall,C. glabratastrains were good producers of catalase, aspartic protease, esterase, phytase, and hemolysin. However, caseinase and phospholipase in vitro activities were not detected. Statistically significant correlations were identified between micafungin minimum inhibitory concentration (MIC) and esterase production, between fluconazole and micafungin MIC and hemolytic activity, and between amphotericin B MIC and phytase production. These results contribute to clarify some of theC. glabratamechanisms of pathogenicity. Moreover, the association between some virulence attributes and the regulation of antifungal resistance encourage the development of new therapeutic strategies involving virulence mechanisms as potential targets for effective antifungal drug development for the treatment ofC. glabratainfections.

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