Diagnostic Assessment of septin9 DNA Methylation for Colorectal Cancer Using Blood Detection: A Meta-Analysis

2018 ◽  
Vol 25 (4) ◽  
pp. 1525-1534 ◽  
Author(s):  
Gongping Sun ◽  
Jin Meng ◽  
He Duan ◽  
Dewei Zhang ◽  
Yuanxin Tang
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Meta Analysis ◽  
Diagnostic Assessment

scholarly journals The importance of stool DNA methylation in colorectal cancer diagnosis: A meta-analysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200735 ◽  
Author(s):  
Afsaneh Mojtabanezhad Shariatpanahi ◽  
Maryam Yassi ◽  
Mehdi Nouraie ◽  
Amirhossein Sahebkar ◽  
Fatemeh Varshoee Tabrizi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
Stool Dna

scholarly journals DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples

2020 ◽  
Author(s):  
Eivor Alette Laugsand ◽  
Siv Sellæg Brenne ◽  
Frank Skorpen
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Data Extraction ◽  
Meta Analysis ◽  
Methylation Status ◽  
High Sensitivity ◽  
Liquid Biopsies ◽  
Non Invasive ◽  
Paired Samples

Abstract Purpose Methylated cell-free DNA in liquid biopsies are promising non-invasive biomarkers for colorectal cancer (CRC). Optimal markers would have high sensitivity and specificity for early detection of CRC and could be detected in more than one type of material from the patient. We systematically reviewed the literature on DNA methylation markers of colorectal cancer, detected in more than one type of material, regarding their potential as contributors to a panel for screening and follow-up of CRC. Methods The databases MEDLINE, Web of Science, and Embase were systematically searched. Data extraction and review was performed by two authors independently. Agreement between methylation status in tissue and other materials (blood/stool/urine) was analyzed using the McNemar test and Cohen’s kappa. Results From the 51 included studies, we identified seven single markers with sensitivity ≥ 75% and specificity ≥ 90% for CRC. We also identified one promising plasma panel and two stool panels. The correspondence of methylation status was evaluated as very good for four markers, but only marginal for most of the other markers investigated (12 of 21). Conclusion The included studies reported only some of the variables and markers of interest and included few patients. Hence, a meta-analysis was not possible at this point. Larger, prospective studies must be designed to study the discordant detection of markers in tissue and liquid biopsies. When reporting their findings, such studies should use a standardized format.

Performance Evaluation of Stool DNA Methylation Tests in Colorectal Cancer Screening: A Systematic Review and Meta‐analysis

2021 ◽  
Author(s):  
Mahir Gachabayov ◽  
Edward Lebovics ◽  
Aram Rojas ◽  
Daniel M Felsenreich ◽  
Rifat Latifi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Dna Methylation ◽  
Performance Evaluation ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Meta Analysis ◽  
Stool Dna

A systematic review and meta-analysis of the DNA methylation in colorectal cancer among Iranian population

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101080
Author(s):  
Soraya Bilvayeh ◽  
Zohreh Rahimi ◽  
Kheirollah Yari ◽  
Shayan Mostafaei
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Dna Methylation ◽  
Meta Analysis ◽  
Iranian Population
Sign in / Sign up

Export Citation Format

Share Document