scholarly journals The importance of stool DNA methylation in colorectal cancer diagnosis: A meta-analysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200735 ◽  
Author(s):  
Afsaneh Mojtabanezhad Shariatpanahi ◽  
Maryam Yassi ◽  
Mehdi Nouraie ◽  
Amirhossein Sahebkar ◽  
Fatemeh Varshoee Tabrizi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
Stool Dna

Performance Evaluation of Stool DNA Methylation Tests in Colorectal Cancer Screening: A Systematic Review and Meta‐analysis

2021 ◽  
Author(s):  
Mahir Gachabayov ◽  
Edward Lebovics ◽  
Aram Rojas ◽  
Daniel M Felsenreich ◽  
Rifat Latifi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Dna Methylation ◽  
Performance Evaluation ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Meta Analysis ◽  
Stool Dna

scholarly journals Methylation of SFRP2 gene as a promising noninvasive biomarker using feces in colorectal cancer diagnosis: a systematic meta-analysis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Qihua Yang ◽  
Tao Huang ◽  
Guoliang Ye ◽  
Bojun Wang ◽  
Xinjun Zhang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
Noninvasive Biomarker

MicroRNA-21 as a Potential Biomarker for Colorectal Cancer Diagnosis: A Meta-analysis

2016 ◽  
Vol 17 (8) ◽  
pp. 1-13
Author(s):  
Chao-Hui Zhen ◽  
Guo-Jun Yao ◽  
Yan Tan ◽  
Lu Yang ◽  
Xiao-Fang Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
Potential Biomarker

scholarly journals DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples

2020 ◽  
Author(s):  
Eivor Alette Laugsand ◽  
Siv Sellæg Brenne ◽  
Frank Skorpen
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Data Extraction ◽  
Meta Analysis ◽  
Methylation Status ◽  
High Sensitivity ◽  
Liquid Biopsies ◽  
Non Invasive ◽  
Paired Samples

Abstract Purpose Methylated cell-free DNA in liquid biopsies are promising non-invasive biomarkers for colorectal cancer (CRC). Optimal markers would have high sensitivity and specificity for early detection of CRC and could be detected in more than one type of material from the patient. We systematically reviewed the literature on DNA methylation markers of colorectal cancer, detected in more than one type of material, regarding their potential as contributors to a panel for screening and follow-up of CRC. Methods The databases MEDLINE, Web of Science, and Embase were systematically searched. Data extraction and review was performed by two authors independently. Agreement between methylation status in tissue and other materials (blood/stool/urine) was analyzed using the McNemar test and Cohen’s kappa. Results From the 51 included studies, we identified seven single markers with sensitivity ≥ 75% and specificity ≥ 90% for CRC. We also identified one promising plasma panel and two stool panels. The correspondence of methylation status was evaluated as very good for four markers, but only marginal for most of the other markers investigated (12 of 21). Conclusion The included studies reported only some of the variables and markers of interest and included few patients. Hence, a meta-analysis was not possible at this point. Larger, prospective studies must be designed to study the discordant detection of markers in tissue and liquid biopsies. When reporting their findings, such studies should use a standardized format.

Digital Detection of Multiple Minority Mutants in Stool DNA for Noninvasive Colorectal Cancer Diagnosis

2012 ◽  
Vol 84 (13) ◽  
pp. 5645-5652 ◽  
Author(s):  
Lili Deng ◽  
Zongtai Qi ◽  
Binjie Zou ◽  
Haiping Wu ◽  
Huan Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Digital Detection ◽  
Stool Dna ◽  
Multiple Minority

The value of microRNAs as the novel biomarkers for colorectal cancer diagnosis: A meta-analysis

2020 ◽  
Vol 216 (10) ◽  
pp. 153130
Author(s):  
Zhihua Zuo ◽  
Yao Jiang ◽  
Shanshui Zeng ◽  
Yiqin Li ◽  
Jia Fan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Meta Analysis ◽  
The Novel ◽  
Novel Biomarkers

scholarly journals Improved Stool DNA Integrity Method for Early Colorectal Cancer Diagnosis

2014 ◽  
Vol 23 (11) ◽  
pp. 2553-2560 ◽  
Author(s):  
Claudia Rengucci ◽  
Giulia De Maio ◽  
Maura Menghi ◽  
Emanuela Scarpi ◽  
Simona Guglielmo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Early Colorectal Cancer ◽  
Dna Integrity ◽  
Stool Dna

Diagnostic Assessment of septin9 DNA Methylation for Colorectal Cancer Using Blood Detection: A Meta-Analysis

2018 ◽  
Vol 25 (4) ◽  
pp. 1525-1534 ◽  
Author(s):  
Gongping Sun ◽  
Jin Meng ◽  
He Duan ◽  
Dewei Zhang ◽  
Yuanxin Tang
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Meta Analysis ◽  
Diagnostic Assessment

scholarly journals CK20 mRNA expression in serum as a biomarker for colorectal cancer diagnosis: A meta-analysis

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 347-353
Author(s):  
Baoyan Ji ◽  
Xiongfei Cheng ◽  
Xiaojun Cai ◽  
Chuiyan Kong ◽  
Qingyan Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mrna Expression ◽  
Sensitivity And Specificity ◽  
Cancer Diagnosis ◽  
Roc Curve ◽  
Meta Analysis ◽  
Random Effect ◽  
Diagnostic Sensitivity ◽  
Diagnostic Sensitivity And Specificity ◽  
Effect Method

AbstractThe aim of this study was to evaluate the diagnostic value of serumCK20 mRNA as a biomarker for colorectal cancer diagnosis by meta-analysis.Clinical studies related to serum CK20 mRNA expression for colorectal cancer diagnosis were searched in the databases of Pubmed, Cochrane Library, Embase, ISI Web of Knowledge, CNKI and Wanfang. The number of true positive (tp), false positive (fp), false negative (fn) and true negative (tn) of the original included publications were extracted by two reviewers independently. The diagnostic sensitivity, specificity, positive likely hood ratio (+LR), negative likelyhood ratio (-LR), diagnostic odds ratio (DOR) and area under the symmetric ROC curve (AUC) were pooled by random or fixed effect method according to the statistical heterogeneity among the studies.After screening the databases, nineteen publications met the inclusion criteria and were finally included in this meta-analysis. The diagnostic sensitivity and specificity were pooled by random effect model(I2>50%). The pooled diagnostic sensitivity and specificity of CK20 mRNA in serum as biomarker for colorectal cancer were 0.49 (95% CI:0.46 to 0.51) and 0.94 (95%CI:0.92-0.96) respectively. The pooled +LR and −LR were 10.90 (95%CI:5.78 to 20.55) and 0.51 (95%CI:0.45 to 0.57) respectively by random-effect method. The pooled DOR was 22.31 with the 95% CI of 11.65 to 42.71. The pooled area under the ROC curve (AUC) was 0.72for CK20 mRNA in serum as a biomarker for colorectal cancer diagnosis. Conclusion Serum CK20 mRNA expression was significantly elevated in colorectal cancer patients which could be a promising serum biomarker for colorectal cancer diagnosis with high specificity.

A systematic review and meta-analysis of the DNA methylation in colorectal cancer among Iranian population

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101080
Author(s):  
Soraya Bilvayeh ◽  
Zohreh Rahimi ◽  
Kheirollah Yari ◽  
Shayan Mostafaei
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Dna Methylation ◽  
Meta Analysis ◽  
Iranian Population
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