scholarly journals Comparing GWAS and Brain Structure-Specific Gene Expression Profiles Identifies Psychiatric Disorder-Related Brain Structures at Different Developmental Stages

2020 ◽  
Vol 36 (9) ◽  
pp. 1046-1050
Author(s):  
Xin Qi ◽  
Cuiyan Wu ◽  
Yanan Du ◽  
Shiqiang Cheng ◽  
Yan Wen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Psychiatric Disorder ◽  
Brain Structure ◽  
Developmental Stages ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Brain Structures ◽  
Specific Gene ◽  
Specific Gene Expression

Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation

Heart Rhythm ◽  
2013 ◽  
Vol 10 (3) ◽  
pp. 383-391 ◽  
Author(s):  
Yung-Hsin Yeh ◽  
Chi-Tai Kuo ◽  
Yun-Shien Lee ◽  
Yuan-Min Lin ◽  
Stanley Nattel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Atrial Fibrillation ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Specific Gene ◽  
Specific Gene Expression

Association of specific gene expression profiles with a pathologic complete response to neoadjuvant therapy in esophageal adenocarcinoma.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 51-51
Author(s):  
Patrick James McLaren ◽  
Anthony P Barnes ◽  
Willy Z Terrell ◽  
Gina M. Vaccaro ◽  
Jack Wiedrick ◽  
...  
Keyword(s):  
Gene Expression ◽  
Esophageal Cancer ◽  
Neoadjuvant Therapy ◽  
Esophageal Adenocarcinoma ◽  
Expression Profiles ◽  
Pathologic Complete Response ◽  
Gene Expression Profiles ◽  
Complete Response ◽  
Specific Gene ◽  
Specific Gene Expression

51 Background: Predicting prognosis in esophageal cancer remains an unrealized goal despite studies linking constellations of genes to therapeutic response. In this study, we analyzed specific predictor genes expressed in tumor specimens from our institutional repository. Our aim was to determine if specific gene expression profiles are associated with pathologic complete response (pCR) after neoadjuvant chemo-radiotherapy (CRT). Methods: We investigated eleven genes identified from prior studies (CCL28, SPARC, S100A2, SPRR3, SIRT2, NOV, PERP, PAPSS2, DCK, DKK3, ALDH1) that have significant association with esophageal cancer progression. Patients with esophageal adenocarcinoma treated with neoadjuvant CRT followed by esophagectomy at our institution between January 2011 and July 2015 were included. Quantitative real-time polymerase chain reaction was conducted on pre-treatment biopsy specimens to determine gene expression. Patients were classified into two groups: 1) pCR and, 2) no or poor response (NR) after CRT based on final pathology report. An omnibus test using Mahalanobis distance was applied to evaluate overall genetic expression differences between groups. Log-rank tests compared the differential expression of individual genes. Results: 29 patients (11 pCR and 18 NR) were analyzed. Overall, gene expression profiles were significantly different between pCR and NR patients (p < 0.01). In particular, CCL28 was over-expressed in pCR (Log-HR: 1.53, 95%CI: 0.46-2.59, p = 0.005), and DKK3-was under-expressed in pCR patients (Log-HR: -1.03 95%CI: -1.97, -0.10, p = 0.031). Conclusions: Esophageal adenocarcinoma patients with a pCR after neoadjuvant therapy have genetic profiles that are significantly different from typical NR profiles. In our population, the genes CCL28 and DKK3 are potential predictors of treatment response.

scholarly journals Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma

BMC Cancer ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Cinzia Lavarino ◽  
Nai-Kong V Cheung ◽  
Idoia Garcia ◽  
Gema Domenech ◽  
Carmen de Torres ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chromosomal Abnormalities ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Specific Gene ◽  
Specific Gene Expression

scholarly journals Brain region-specific gene expression profiles in freshly isolated rat microglia

2015 ◽  
Vol 9 ◽  
Author(s):  
Karlijn J. Doorn ◽  
John J. P. Brevé ◽  
Benjamin Drukarch ◽  
Hendrikus W. Boddeke ◽  
Inge Huitinga ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brain Region ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Isolated Rat

scholarly journals Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury

2017 ◽  
Vol 37 (6) ◽  
Author(s):  
Marc Weidenbusch ◽  
Severin Rodler ◽  
Shangqing Song ◽  
Simone Romoli ◽  
Julian A. Marschner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Tissue Injury ◽  
Expression Profiles ◽  
Notch Pathway ◽  
Gene Expression Profiles ◽  
Sterile Inflammation ◽  
Specific Gene ◽  
Specific Gene Expression

Notch and interleukin-22 (IL-22) signaling are known to regulate tissue homeostasis and respond to injury in humans and mice, and the induction of endogenous aryl hydrocarbon receptor (Ahr) ligands through Notch links the two pathways in a hierarchical fashion. However in adults, the species-, organ- and injury-specific gene expression of the Notch-AhR-IL22 axis components is unknown. We therefore performed gene expression profiling of DLL1, DLL3, DLL4, DLK1, DLK2, JAG1, JAG2, Notch1, Notch2, Notch3, Notch4, ADAM17/TNF-α ADAM metalloprotease converting enzyme (TACE), PSEN1, basigin (BSG)/CD147, RBP-J, HES1, HES5, HEY1, HEYL, AHR, ARNT, ARNT2, CYP1A1, CYP24A1, IL-22, IL22RA1, IL22RA2, IL10RB, and STAT3 under homeostatic conditions in ten mature murine and human organs. Additionally, the expression of these genes was assessed in murine models of acute sterile inflammation and progressive fibrosis. We show that there are organ-specific gene expression profiles of the Notch-AhR-IL22 axis in humans and mice. Although there is an overall interspecies congruency, specific differences between human and murine expression signatures do exist. In murine tissues with AHR/ARNT expression CYP1A1 and IL-22 were correlated with HES5 and HEYL expression, while in human tissues no such correlation was found. Notch and AhR signaling are involved in renal inflammation and fibrosis with specific gene expression changes in each model. Despite the presence of all Notch pathway molecules in the kidney and a model-specific induction of Notch ligands, IL-22 was only up-regulated in acute inflammation, but rapidly down-regulated during regeneration. This implies that for targeting injury responses, e.g. via IL-22, species-specific differences, injury type and time points have to be considered.

scholarly journals Ketamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles

2017 ◽  
Vol 81 (4) ◽  
pp. 285-295 ◽  
Author(s):  
Rosemary C. Bagot ◽  
Hannah M. Cates ◽  
Immanuel Purushothaman ◽  
Vincent Vialou ◽  
Elizabeth A. Heller ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Specific Gene ◽  
Specific Gene Expression

scholarly journals mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft

BMC Genomics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 521 ◽  
Author(s):  
Darren Magda ◽  
Philip Lecane ◽  
Julia Prescott ◽  
Patricia Thiemann ◽  
Xuan Ma ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Human Cells ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Mtdna Depletion
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