Histamine H1 Receptor in Basal Forebrain Cholinergic Circuit: A Novel Target for the Negative Symptoms of Schizophrenia?

2021 ◽  
Author(s):  
Shuangshuang Wu ◽  
Chenshu Gao ◽  
Feng Han ◽  
Heming Cheng
Keyword(s):  
Basal Forebrain ◽  
Negative Symptoms ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Novel Target

scholarly journals Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Li Cheng ◽  
Cenglin Xu ◽  
Lu Wang ◽  
Dadao An ◽  
Lei Jiang ◽  
...  
Keyword(s):  
Functional Outcomes ◽  
Negative Symptoms ◽  
Cholinergic Neurons ◽  
Sensorimotor Gating ◽  
Social Impairment ◽  
H1 Receptor ◽  
Behavioral Deficits ◽  
Social Impairments ◽  
Cholinergic Projections ◽  
Functional Deficiency

AbstractNegative symptoms in schizophrenia strongly contribute to poor functional outcomes, however its pathogenesis is still unclear. Here, we found that histamine H1 receptor (H1R) expression in basal forebrain (BF) cholinergic neurons was decreased in patients with schizophrenia having negative symptoms. Deletion of H1R gene in cholinergic neurons in mice resulted in functional deficiency of cholinergic projections from the BF to the prefrontal cortex and in the formation of sensorimotor gating deficit, social impairment and anhedonia-like behavior. These behavioral deficits can be rescued by re-expressing H1R or by chemogenetic activation of cholinergic neurons in the BF. Direct chemogenetic inhibition of BF cholinergic neurons produced such behavioral deficits and also increased the susceptibility to hyperlocomotion. Our results suggest that the H1R deficiency in BF cholinergic neurons is critical for sensorimotor gating deficit, social impairments and anhedonia-like behavior. This finding may help to understand the genetic and biochemical bases of negative symptoms in schizophrenia.

scholarly journals Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis

2017 ◽  
Vol 8 (5) ◽  
pp. 577-581 ◽  
Author(s):  
Panayiotis A. Procopiou ◽  
Alison J. Ford ◽  
Paul M. Gore ◽  
Brian E. Looker ◽  
Simon T. Hodgson ◽  
...  
Keyword(s):  
H1 Receptor ◽  
Receptor Antagonists ◽  
Histamine H1 Receptor

Histamine H1 receptor ligands

Il Farmaco ◽  
1999 ◽  
Vol 54 (8) ◽  
pp. 533-541 ◽  
Author(s):  
K. Walczyński ◽  
H. Timmerman ◽  
O.P. Zuiderveld ◽  
M.Q. Zhang ◽  
R. Glinka
Keyword(s):  
Receptor Ligands ◽  
H1 Receptor ◽  
Histamine H1 Receptor

scholarly journals Histamine H1 -receptor-mediated modulation of the delayed rectifier K+ current in guinea-pig atrial cells: opposite effects on IKs and IKr

1999 ◽  
Vol 128 (7) ◽  
pp. 1545-1553 ◽  
Author(s):  
Yasunori Matsumoto ◽  
Takehiko Ogura ◽  
Hiroko Uemura ◽  
Toshihiro Saito ◽  
Yoshiaki Masuda ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Delayed Rectifier ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Atrial Cells ◽  
K Current
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