Surface properties of encapsulating hydrophobic nanoparticles regulate the main phase transition temperature of lipid bilayers: A simulation study

Nano Research ◽  
2014 ◽  
Vol 7 (8) ◽  
pp. 1195-1204 ◽  
Author(s):  
Xubo Lin ◽  
Ning Gu
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Surface Properties ◽  
Lipid Bilayers ◽  
Phase Transition Temperature ◽  
Simulation Study ◽  
Main Phase

scholarly journals Variation of thermal conductivity of DPPC lipid bilayer membranes around the phase transition temperature

2017 ◽  
Vol 14 (130) ◽  
pp. 20170127 ◽  
Author(s):  
Sina Youssefian ◽  
Nima Rahbar ◽  
Christopher R. Lambert ◽  
Steven Van Dessel
Keyword(s):  
Phase Transition ◽  
Thermal Conductivity ◽  
Thermal Properties ◽  
Transition Temperature ◽  
Lipid Bilayer ◽  
Lipid Bilayers ◽  
Phase Transition Temperature ◽  
Temperature Gradients ◽  
Phase Behaviour ◽  
Gel Phase

Given their amphiphilic nature and chemical structure, phospholipids exhibit a strong thermotropic and lyotropic phase behaviour in an aqueous environment. Around the phase transition temperature, phospholipids transform from a gel-like state to a fluid crystalline structure. In this transition, many key characteristics of the lipid bilayers such as structure and thermal properties alter. In this study, we employed atomistic simulation techniques to study the structure and underlying mechanisms of heat transfer in dipalmitoylphosphatidylcholine (DPPC) lipid bilayers around the fluid–gel phase transformation. To investigate this phenomenon, we performed non-equilibrium molecular dynamics simulations for a range of different temperature gradients. The results show that the thermal properties of the DPPC bilayer are highly dependent on the temperature gradient. Higher temperature gradients cause an increase in the thermal conductivity of the DPPC lipid bilayer. We also found that the thermal conductivity of DPPC is lowest at the transition temperature whereby one lipid leaflet is in the gel phase and the other is in the liquid crystalline phase. This is essentially related to a growth in thermal resistance between the two leaflets of lipid at the transition temperature. These results provide significant new insights into developing new thermal insulation for engineering applications.

scholarly journals The Effect of Selected Anions on Dipalmitoylphosphatidylcholine Phase Transitions

2002 ◽  
Vol 57 (7-8) ◽  
pp. 712-716 ◽  
Author(s):  
Adriana Przyczyna ◽  
Bożenna Różycka-Roszk ◽  
Marek Langner
Keyword(s):  
Phase Transition ◽  
Phase Transitions ◽  
Transition Temperature ◽  
Phase Transition Temperature ◽  
Salt Concentration ◽  
Half Width ◽  
Main Phase ◽  
Interface Properties ◽  
Transition Enthalpy ◽  
Peak Half Width

The effect of three anions, Cl-, Br- and I-, on the phase transitions of dipalmitoylphosphatidylcholine (DPPC) was measured. Main phase transition was modestly affected by these anions in the salt concentration range 0.2 M. For Cl- and Br- the temperature of main phase transition was lower (by about 0.5 °C), its half-width modestly larger and enthalpy practically unchanged, all three parameters were altered to a much larger degree. Main phase transition temperature was 1.5 °C lower and the peak half-width significantly smaller. These changes were not accompanied by any alteration in main phase transition enthalpy. Iodide shifted the pretransition temperature toward lower values and increased its half-width to such an extent that at concentrations above 100 mm it was practically undetectable. Besides cations, the presence of anions also has a distinct effect on lipid bilayer interface properties.

scholarly journals Morphological Behavior of Lipid Bilayers Induced by Melittin near the Phase Transition Temperature

2005 ◽  
Vol 89 (5) ◽  
pp. 3214-3222 ◽  
Author(s):  
Shuichi Toraya ◽  
Takashi Nagao ◽  
Kazushi Norisada ◽  
Satoru Tuzi ◽  
Hazime Saitô ◽  
...  
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Lipid Bilayers ◽  
Phase Transition Temperature ◽  
Morphological Behavior

A Semisynthetic 5-n-Alkylresorcinol Derivative and its Effect upon Biomembrane Properties

2007 ◽  
Vol 62 (11-12) ◽  
pp. 881-888 ◽  
Author(s):  
Maria Stasiuk ◽  
Dominika Bartosiewicz ◽  
Jerzy Gubernator ◽  
Katarzyna Cieslik-Boczula ◽  
Martin Hof ◽  
...  
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Phase Transition Temperature ◽  
Ph Value ◽  
Membrane Surface ◽  
Main Phase ◽  
Phospholipid Bilayer ◽  
Low Concentrations ◽  
Packing Defects ◽  
Semisynthetic Derivative

MSAR (1-sulfate-3-myristoyl-5-pentadecylbenzene) is a semisynthetic derivative of 5-npentadecylresorcinol (C15:0). MSAR exhibits hemolytic activity against sheep erythrocytes with a EH50 value of (35 ± 1.7) μm. At low concentrations MSAR also exhibits the ability to protect cells against their hypoosmotic lysis. This protective effect is significant as, at 0.1 μm of MSAR, the extent of osmotically induced cell lysis is reduced by approx. 20%. It was demonstrated that the 9-anthroyloxystearic acid signal was most intensively quenched by MSAR molecules, suggesting a relatively deep location of these molecules within the lipid bilayer. MSAR causes an increase of the fluorescence of the membrane potential sensitive probe. This indicates an alteration of the surface charge and a decrease of the local pH value at the membrane surface. At low bilayer content (1-4 mol%) this compound causes a significant increase of the phospholipid bilayer fluidity (both under and above the main phase transition temperature) of dipalmitoylphosphatidylcholine (DPPC) liposomes. At this low content MSAR slightly decreases the main phase transition temperature (Tc) value. The effects induced in the phospholipid bilayer by higher contents of MSAR molecules (5-10 mol%) make it impossible to determine the Tc value and to evaluate changes of the membrane fluidity by using pyrene-labeled lipid. MSAR also causes a decrease of the activity of membrane-bound enzymes-red blood cell acetylcholinesterase (AChE) and phospholipase A2 (PLA2). MSAR decreases the AChE activity by 40% at 100 μm. The presence of MSAR in the liposomal membrane induces a complete abolishment of the lag time of the PLA2 activity, indicating that these molecules induce the formation of packing defects in the bilayer which may result from imperfect mixing of phospholipids.

Formation of supported lipid bilayers on silica: relation to lipid phase transition temperature and liposome size

Soft Matter ◽  
2014 ◽  
Vol 10 (1) ◽  
pp. 187-195 ◽  
Author(s):  
Yujia Jing ◽  
Hana Trefna ◽  
Mikael Persson ◽  
Bengt Kasemo ◽  
Sofia Svedhem
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Lipid Bilayers ◽  
Phase Transition Temperature ◽  
Supported Lipid Bilayers ◽  
Lipid Phase ◽  
Lipid Phase Transition ◽  
Liposome Size
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