Risk Factors for Lead Toxicity and its Effect on Neurobehavior in Indian Children

Author(s):  
L. Malavika ◽  
Taru Goyal ◽  
Prasenjit Mitra ◽  
Gangam Saikiran ◽  
Shailja Sharma ◽  
...  
2021 ◽  
pp. 29-30
Author(s):  
Harshawardhan V Tanwar ◽  
Uttam Wadavkar

Introduction: Metabolic abnormalities are common cause of urolithiasis in pediatric age group. Children with urolithiasis are associated with considerable morbidity. By treating these abnormalities stone formation is prevented. Objectives: Prospective study to nd the metabolic risk factors of urolithiasis in children and compare them with literature. Materials and Methods: In open, prospective and observational study, 85 children were evaluated from August 2019 to June 2020. In all patients' dietary history, water intake and results of laboratory ndings were recorded. All urine samples obtained from patients were without dietary restrictions. Reference pediatric 24 hour urinary parameter was used according to western literature. Results: We investigated 85 patients with urolithiasis. Low urine volume was found in 52 patients which is comparable with previous studies indicating simple intervention as to increase water intake. Low calcium intake was found in 48 patients suggesting that low calcium intake is associated with higher incidence of urolithiasis due to increased intestinal oxalate absorption. Hypocalcaemia was found in 34 patients and 24 hour urinary abnormality was found in only 18 patients'. Both these nding does not support previous literature. Stone analysis nding does not correlate with urinary nding. Conclusions: Hypocalcaemia is major metabolic abnormality in contradiction to western literature. Low urine volume secondary to low water intake is predominant nding .There are no nomograms for urinary excretion of Calcium, uric acid, oxalate and citrate in Indian children. Keeping the optimum blood calcium level & increased uid intake can prevent stone formation in children.


Author(s):  
Mansi Dhami ◽  
Felix Ogbo ◽  
Thierno Diallo ◽  
Kingsley Agho ◽  

Studies on the association between infant and young child feeding (IYCF) practices and diarrhoea across regional India are limited. Hence, we examined the association between IYCF practices and diarrhoea in regional India. A weighted sample of 90,596 (North = 11,200, South = 16,469, East = 23,317, West = 11,512, Central = 24,870 and North-East = 3228) from the 2015–2016 National Family Health Survey in India was examined, using multivariate logistic regressions that adjust for clustering and sampling weights. The IYCF indicators included early initiation of breastfeeding (EIBF), exclusive breastfeeding (ExcBF), predominant breastfeeding (PBF), bottle feeding (BotF), continued breastfeeding (BF) at one-year, continued BF at two years, children ever breastfed and the introduction of solid, semi-solid or soft foods (ISSSF). Diarrhoea prevalence was lower among infants who were BF within one-hour of birth and those who were exclusively breastfed. Multivariate analyses revealed that continued BF at one and two years, and infants who were introduced to complementary foods had a higher prevalence of diarrhoea. EIBF and ExcBF were protective against diarrhoea in the regions of North, East and Central India. PBF, BotF and ISSSF were risk factors for diarrhoea in Central India. Continued BF at two years was a risk factor for diarrhoea in Western India. Findings suggested that EIBF and ExcBF were protective against diarrhoea in Northern, Eastern and Central India, while PBF, BotF, continued BF at two years and ISSSF were risk factors for diarrhoea in various regions in India. Improvements in IYCF practices are likely to reduce the burden of diarrhoea-related morbidity and mortality across regions in India.


2002 ◽  
Vol 12 (7) ◽  
pp. 502
Author(s):  
BH Sambo ◽  
LH Malcoe ◽  
JE Eichner ◽  
WE Moore ◽  
ET Lee ◽  
...  

2012 ◽  
Vol 31 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Anuradha V Khadilkar ◽  
Shashi A Chiplonkar ◽  
Deepa S Pandit ◽  
Arun S Kinare ◽  
Vaman V Khadilkar

2021 ◽  
Author(s):  
Jatinder Singh Goraya ◽  
Shivankshi Berry ◽  
Amandeep Kaur ◽  
Gagandeep Singh

AbstractThere are not enough recent studies on arterial ischemic stroke (AIS) in Indian children. We retrospectively reviewed data on 95 children (69 boys), aged 3 months to 17 years, with AIS. Focal signs were noted in 84 (88%) with hemiparesis in 72 (76%). Diffuse signs were present in 33 (35%) with fever in 22 (23%), altered mental status in 20 (21%), and headache in 12 (13%). Seizures occurred in 29 (31%) children. Arteriopathy was observed in 57 (60%) children with mineralizing lenticulostriate vasculopathy (mLSV) in 22 (23%) being the most common, followed by moyamoya in 14 (15%), arterial dissection in 9 (10%), and focal cerebral arteriopathy (FCA) in 8 (8%). Preceding head/neck trauma was present in 27 (28%) children: 23 had minor head trauma (MHT), 3 neck trauma, and 1 unspecified. Other common risk factors (RFs) were iron deficiency in 10 children, homocysteinemia in 8 children, and tuberculous meningitis in 5 children. Complete or nearly complete recovery occurred in 42 (44%). Nine children developed epilepsy and five cognitive and language disability. Stroke recurrences occurred in nine children. Overall, arteriopathies accounted for majority of the cases of childhood AIS in our study with mLSV and moyamoya being the most frequent. Compared with data from Western countries, FCAs, postvaricella arteriopathy, and arterial dissections were less common. Of the nonarteriopathic RFs, MHT, iron deficiency, homocysteinemia, and neuroinfections were most frequent in our cohort in contrast to cardioembolic diseases and inherited procoagulant conditions, which are common in developed countries.


2010 ◽  
Vol 74 (6) ◽  
pp. 677-683 ◽  
Author(s):  
A. Sophia ◽  
Rita Isaac ◽  
Grace Rebekah ◽  
K. Brahmadathan ◽  
V. Rupa

2019 ◽  
Vol 8 ◽  
pp. 216495611987098 ◽  
Author(s):  
Julia Keosaian ◽  
Thuppil Venkatesh ◽  
Salvatore D’Amico ◽  
Paula Gardiner ◽  
Robert Saper

Background Traditional Indian cosmetics and Ayurvedic medicines may contain lead. Previous studies have shown a relationship between eye cosmetic use (kohl) in children and elevated blood lead levels (BLLs) > 10 µg/dL. However, an association between Ayurvedic use and elevated BLLs in children is unknown and understudied. Methods We assessed the feasibility of collecting BLLs in children attending Ayurvedic outpatient settings in India. Our pilot study took place over 3 days in the summer of 2010 at a large public Ayurveda hospital and a small pediatric clinic in southern India. Using a trained interpreter, we administered a standardized questionnaire in Malayalam, assessing sociodemographics, Ayurvedic medicine use, kohl use, and other potential risk factors for lead exposure, to parents of pediatric outpatients. We also analyzed BLLs using a portable lead analyzer. Results The study enrolled 29 children (mean age, 3.8 years). The mean BLL was 6.7 µg/dL (SD = 3.5; range, 3.5–20.2). Seventy-two percent of the children used Ayurvedic medicine in the past 2 years and 55% reported kohl use. Mean BLL of Ayurvedic users and nonusers was 6.2 µg/dL and 8.5 µg/dL, respectively ( P = .08). Kohl users had a statistically significant higher BLL than nonusers (8.0 µg/dL vs 5.3 µg/dL, P = .03). Conclusions It is feasible to collect BLLs in pediatric Ayurvedic outpatient clinics in southern India. Collaborative relationships with community members and hospital staff were essential. Further research is needed to investigate Ayurveda and kohl use as risk factors for elevated lead burden among Indian children.


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