Reactivation of hepatitis C virus with severe hepatitis flare during steroid administration for interstitial pneumonia

2021 ◽  
Author(s):  
Kosuke Sato ◽  
Jun Inoue ◽  
Eiji Kakazu ◽  
Masashi Ninomiya ◽  
Tomoaki Iwata ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Interstitial Pneumonia ◽  
Steroid Administration ◽  
Severe Hepatitis ◽  
Hepatitis Flare

scholarly journals A Hepatitis C Virus-Associated Cirrhotic Patient Developing Interstitial Pneumonia during the Course of Antiviral Therapy with Ombitasvir/Paritaprevir/Ritonavir

2017 ◽  
Vol 11 (2) ◽  
pp. 369-376 ◽  
Author(s):  
Kazuo Tarao ◽  
Kouzo Yamada
Keyword(s):  
Computed Tomography ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Interstitial Pneumonia ◽  
Total Duration ◽  
Drug Discontinuation ◽  
Chest Computed Tomography ◽  
Hcv Genotype ◽  
Genotype 1B ◽  
Direct Acting

Oral direct-acting antivirals (DAAs) are the main therapy for hepatitis C virus (HCV)-associated liver disease in Japan. Daclatasvir/asunaprevir is the first agent and sofosbuvir/ledipasvir is the secondary agent for HCV genotype 1b. More recently, ombitasvir/paritaprevir/ritonavir is also recommended as a potent therapy for HCV genotype 1b. Among the adverse events associated with these oral DAAs, interstitial pneumonia is one of the most severe ones. Regarding treatment with daclatasvir plus asunaprevir or sofosbuvir plus ledipasvir, a few cases have already been reported in a postmarketing surveillance. Recently, we have encountered a HCV-associated genotype 1b cirrhosis patient who developed interstitial pneumonia during treatment with ombitasvir/paritaprevir/ritonavir and who recovered after drug discontinuation without corticosteroid therapy. Interstitial pneumonia was confirmed by chest x-ray and chest computed tomography. The serum KL-6 level was elevated to 1,180 U/mL. The total duration of the drug administration was 7 weeks, and she achieved SVR24. This is the first detailed report in the literature on the development of interstitial pneumonia during treatment with ombitasvir/paritaprevir/ritonavir. When dry cough appeared in the treatment with DAAs, chest computed tomography and the evaluation of serum KL-6 level were recommended.

SEVERE HEPATITIS DUE TO CO-INFECTION WITH HIV AND HEPATITIS C VIRUS IN A YOUNG INFANT

AIDS ◽  
1994 ◽  
Vol 8 (Supplement 4) ◽  
pp. S48
Author(s):  
C-A. Wyler ◽  
D. Belli ◽  
S. Suter ◽  
M. Schappi ◽  
P. Pilloux ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Young Infant ◽  
Severe Hepatitis

Increased Risk of Severe Hepatitis C Virus Recurrence After Liver Transplantation in Patients With a T Allele of IL28B rs12979860

2012 ◽  
Vol 94 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Elisa Cisneros ◽  
Isolina Baños ◽  
María Jesús Citores ◽  
Ana Duca ◽  
Clara Salas ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Severe Hepatitis ◽  
Increased Risk

Hepatitis C virus genotypes and severe hepatitis C virus recurrence after liver transplantation

1997 ◽  
Vol 29 (1-2) ◽  
pp. 522-523 ◽  
Author(s):  
A.B. Alberti ◽  
L.S. Belli ◽  
E. Silini ◽  
C. Zavaglia ◽  
G. Iamoni ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Severe Hepatitis ◽  
Virus Genotypes ◽  
Hepatitis C Virus Genotypes

scholarly journals Heterologous T cell immunity in severe hepatitis C virus infection

2005 ◽  
Vol 201 (5) ◽  
pp. 675-680 ◽  
Author(s):  
Simona Urbani ◽  
Barbara Amadei ◽  
Paola Fisicaro ◽  
Massimo Pilli ◽  
Gabriele Missale ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Infection ◽  
Cell Response ◽  
Cd8 T Cell ◽  
Cross Reactivity ◽  
T Cell Response ◽  
Hcv Infection ◽  
Severe Hepatitis

Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to shape the repertoire of the primary response and to influence virus-related immunopathology (Selin, L.K. 2004. Immunity. 20:5–16). To determine whether this mechanism can influence the course of HCV infection, we analyzed the features of the HCV-specific CD8 T cell response in eight patients with acute HCV infection, two of whom had a particularly severe illness. Patients with severe hepatitis, but not those with mild disease, showed an extremely vigorous CD8 T cell response narrowly focused on a single epitope (NS3 1073–1081), which cross-reacted with an influenza neuraminidase sequence. Our results suggest that CD8 T cell cross-reactivity influences the severity of the HCV-associated liver pathology and depicts a model of disease induction that may apply to different viral infections.

scholarly journals The paradox of NKp46+natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon α treatment

Gut ◽  
2013 ◽  
Vol 63 (3) ◽  
pp. 515-524 ◽  
Author(s):  
Tom Pembroke ◽  
Adam Christian ◽  
Emma Jones ◽  
Robert K Hills ◽  
Eddie C Y Wang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Interferon Α ◽  
Killer Cells ◽  
Severe Hepatitis

Desquamative Interstitial Pneumonia and Hepatitis C Virus Infection: A Rare Association

2004 ◽  
Vol 97 (9) ◽  
pp. 890-893 ◽  
Author(s):  
Said B. Iskandar ◽  
Lisa A. McKinney ◽  
Lata Shah ◽  
Thomas M. Roy ◽  
Ryland P. Byrd
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Interstitial Pneumonia ◽  
Hepatitis C Virus Infection ◽  
Rare Association
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