scholarly journals Therapeutic effect of mefloquine on Schistosoma mansoni in experimental infection in mice

2014 ◽  
Vol 40 (2) ◽  
pp. 259-267 ◽  
Author(s):  
Omaima Mohammed Abou-Shady ◽  
Soheir Sayed Mohammed ◽  
Samar Sayed Attia ◽  
Hebat-Allah Salah Yusuf ◽  
Dina Omar Helmy
Keyword(s):  
Schistosoma Mansoni ◽  
Therapeutic Effect ◽  
Experimental Infection

Polyclonal activation of B lymphocytes during experimental infection with Schistosoma mansoni

Parasitology ◽  
1990 ◽  
Vol 100 (1) ◽  
pp. 83-91 ◽  
Author(s):  
L. M. Lopes ◽  
M. A. C. Pereira ◽  
S. E. Gerken ◽  
N. Vaz
Keyword(s):  
Schistosoma Mansoni ◽  
B Lymphocytes ◽  
Experimental Infection ◽  
Adoptive Transfer ◽  
Cell Activation ◽  
Protein A ◽  
B Cell Activation ◽  
Spleen Cells ◽  
Polyclonal Activation ◽  
Immunoglobulin Isotypes

SummaryA significant polyclonal activation of B lymphocytes was observed during experimental infection of C57BL/10J mice with Schistosoma mansoni. The isotypic pattern of this expansion, assessed by the Protein-A plaque-forming cell method, was compared with and found to differ from those occurring after infection by Trypanosoma cruzi or injection of bacterial LPS. In the infection of S. mansoni an early expansion of most immunoglobulin isotypes occurs together with a late, sustained expansion of IgG1-secreting cells. High levels of polyclonal B cell activation were observed after adoptive transfer of spleen cells from infected mice to isogenic recipients pre-treated with hydroxyurea.

scholarly journals Experimental infection with Schistosoma mansoni of Biomphalaria straminea from different parts of the Northeast of Brazil

1986 ◽  
Vol 28 (3) ◽  
pp. 160-165 ◽  
Author(s):  
E. A. Malek ◽  
M. Z. Rouquayrol
Keyword(s):  
Schistosoma Mansoni ◽  
Puerto Rican ◽  
Experimental Infection ◽  
Snail Host ◽  
The State ◽  
Infection Rates ◽  
Biomphalaria Straminea ◽  
Albino Strain ◽  
Very High ◽  
Different Parts

In the western part of the State of Bahia Biomphalaria straminea and B. glabrata both occur, but in the majority of cases they do not share the same habitat. In the State of Ceará, however, B. straminea is the sole snail host of Schistosoma mansoni. In this survey, no naturally infected B. straminea was found among snails collected from Bahia and Ceará, evidently because of the very low infection rates. The susceptibility of laboratory-reared specimens to infection with a Puerto Rican strain of S. mansoni was then tested experimentally. In general, the snails showed very low susceptibility. The infection rates were 1.1% among snails from Redenção (Ceará); 2.3% in those from Pentecoste (Ceará); 2.9% in snails from São Desidério (Bahia), while they were very high among an albino strain (NIH) of B. glabrata used as control. Another group of B. straminea from São Desidério was exposed to a Bahian strain of S. mansoni and the infection rate was still very low (3.6%) Apparently, the very low susceptibility of B. straminea, despite high snail density, is correlated with moderate infection rates with S. mansoni among humans, as shown by the results of stool examinations conducted by SUCAM in the municipalities of Redenção and Pentecoste, in Ceará.

Diagnostic Mr31/32 000 Schistosoma mansoni proteins (Sm31/32): Reaction with sera from Sudanese patients infected with S. mansoni or S. haematobium

1988 ◽  
Vol 62 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Mohamed A. Idris ◽  
Andreas Ruppel
Keyword(s):  
Molecular Weight ◽  
Schistosoma Mansoni ◽  
Experimental Infection ◽  
Additional Data ◽  
Broad Band ◽  
Urinary Schistosomiasis ◽  
Specificity And Sensitivity ◽  
Endemic Areas ◽  
Potential Use

ABSTRACTSera of Sudanese patients with active infections of Schistosoma mansoni or S. haematobium were tested in immunoblots for their reactivity with Mr31/32 000 proteins of adult S. mansoni (Sm31/32). All sera from patients with intestinal (n=123) and all but one from those with urinary schistosomiasis (n=35) had antibodies against Sm31/32. These and additional data suggest that both specificity and sensitivity of Sm31/32 to detect schistosome infections are close to 100%. Antibodies against these proteins developed also in monkeys after experimental infection with S. haematobium. Sm31/32 antigens reacted in immunoblots as a doublet with most S. haematobium-patient sera and as a broad band with many S. mansoni-sera suggesting that at least two components are present in the molecular weight region of Mr31/32 000. The data demonstrate the potential use of Sm31/32 from adult worms to diagnose patients with intestinal or urinary schistosomiasis in endemic areas.

scholarly journals Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment

2021 ◽  
Vol 15 (5) ◽  
pp. e0009423
Author(s):  
Wegdan M. Abd El Wahab ◽  
Ayman A. El-Badry ◽  
Soheir S. Mohmoud ◽  
Yaser A. El-Badry ◽  
Mohamed A. El-Badry ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Therapeutic Effect ◽  
Worm Burden ◽  
Zingiber Officinale ◽  
Egg Load ◽  
Therapeutic Drug ◽  
Slight Reduction ◽  
Prophylactic Drug ◽  
Egg Density ◽  
Therapeutic Doses

Background Nanotechnology has been manufactured from medicinal plants to develop safe, and effective antischistosmal alternatives to replace today’s therapies. The aim of the study is to evaluate the prophylactic effect of ginger-derived nanoparticles (GNPs), and the therapeutic effect of ginger aqueous extract, and GNPs on Schistosoma mansoni (S. mansoni) infected mice compared to praziquantel (PZQ), and mefloquine (MFQ). Methodology/principal findings Eighty four mice, divided into nine different groups, were sacrificed at 6th, 8th, and 10th week post-infection (PI), with assessment of parasitological, histopathological, and oxidative stress parameters, and scanning the worms by electron microscope. As a prophylactic drug, GNPs showed slight reduction in worm burden, egg density, and granuloma size and number. As a therapeutic drug, GNPs significantly reduced worm burden (59.9%), tissue egg load (64.9%), granuloma size, and number at 10th week PI, and altered adult worm tegumental architecture, added to antioxidant effect. Interestingly, combination of GNPs with PZQ or MFQ gave almost similar or sometimes better curative effects as obtained with each drug separately. The highest therapeutic effect was obtained when ½ dose GNPs combined with ½ dose MFQ which achieved 100% reduction in both the total worm burden, and ova tissue density as early as the 6th week PI, with absence of detected eggs or tissue granuloma, and preservation of liver architecture. Conclusions/significance GNPs have a schistosomicidal, antioxidant, and hepatoprotective role. GNPs have a strong synergistic effect when combined with etiological treatments (PZQ or MFQ), and significantly reduced therapeutic doses by 50%, which may mitigate side effects and resistance to etiological drugs, a hypothesis requiring further research. We recommend extending this study to humans.

scholarly journals Susceptibility of Nectomys rattus (Pelzen, 1883) to experimental infection with Schistosoma mansoni (Sambon, 1907): a potential reservoir in Brazil

1998 ◽  
Vol 93 (suppl 1) ◽  
pp. 295-299 ◽  
Author(s):  
Ana Cláudia Ribeiro ◽  
Arnaldo Maldonado Jr. ◽  
Paulo Sergio D'Andrea ◽  
Giovane Oliveira Vieira ◽  
Luís Rey
Keyword(s):  
Schistosoma Mansoni ◽  
Experimental Infection ◽  
Potential Reservoir

Experimental Infection of the Nine-Banded Armadillo (Dasypus Novemcinctus) with Schistosoma Mansoni (Kenyan Strain)

1988 ◽  
Vol 38 (3) ◽  
pp. 499-507 ◽  
Author(s):  
Jerome H. Smith ◽  
Barbara Doughty ◽  
Elizabeth J. Browder ◽  
W. Michael Kemp ◽  
Fulvantiben D. Mistry
Keyword(s):  
Schistosoma Mansoni ◽  
Experimental Infection ◽  
Dasypus Novemcinctus ◽  
Kenyan Strain

scholarly journals A survey of planorbid molluscs in the Amazonian region of Brazil

1983 ◽  
Vol 78 (3) ◽  
pp. 343-361 ◽  
Author(s):  
W. Lobato Paraense
Keyword(s):  
Schistosoma Mansoni ◽  
Experimental Infection ◽  
Mato Grosso ◽  
Schistosomiasis Mansoni ◽  
Biomphalaria Straminea ◽  
Helisoma Duryi ◽  
Distrito Federal ◽  
In Parenthesis ◽  
Amazonian Region ◽  
Mato Grosso Do Sul

A survey of the plarnorbid fauna in the Brazilian states of the Amazonian river basin revealed the occurence of 14 species, 8 of the genus Biomphalaria, 4 of Drepanotrema, 1 of Antillorbis and 1 of Plesiophysa, besides a naturalized puopulation of Helisoma duryi at Santa Rosa, municipality of Formosa, state of Goiás. The following is the distribution of the species by genera, in decreasing order of frequency (number of localities in parenthesis): 1. Biomphalaria straminea (50): Acre, Amazonas, Distrito Federal, Goiás, Maranhão, Mato Grosso, Mato Grosso do Sul, Pará and Roraima; 2. B. occidentalis (30): Acre, Amazonas, Mato Grosso and Mato Grosso do Sul; 3. B. schrammi (22); Distrito Federal, Goiás, Maranhão, Mato Grosso, Mato Grosso do Sul and Pará; 4. B. amazonica (14): Acre, Amazonas and Rondônia; 5. B. glabrata (13): Distrito Federal, Goiás, Maranhão and Pará; 6. B. peregrina (4): Distrito Federal, Goiás and Mato Grosso do Sul; 7. B. tenagophila (2): Distrito Federal and Goiás; 8. B. oligoza (2): Mato Grosso do Sul; 9. Drepanotrema lucidium (72): Acre, Amapá, Amazonas, Distrito Federal, Goiás, Maranhão, Mato Grosso, Mato Grosso do Sul, Pará, Rondônia and Roraima; 10. D. anatinum (41): Acre, Amazonas, Distrito Federal, Goiás, Maranhão, Mato Grosso do Sul, Pará, Rondônia and Roraima; 11. D. depressissimum (19): Acre, Amazonas, Distrito Federal, Goiás, Maranhão, Mato Grosso, Mato Grosso do Sul and Pará; 12. D. cimex (15): Acre, Amazonas, Distrito Federal, Goiás, Mato Grosso, Mato Grosso do Sul and Pará; 13. Antillorbis nordestensis (3): Distrito Federal, Maranhão and Pará; 14. Plesiophysa ornata (1): Goiás. B. glabrata is responsibel for transmission of schistosomiasis mansoni in northeastern Pará, northern Marnhão and central Goiás including the Distrito Fedreal. B. tenagophila, although susceptible to experimental infection with Schistosoma mansoni, has not been found naturally infected so far in the area. B. straminea has been incriminated as...

scholarly journals The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis

2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Shyama Chatterjee ◽  
Gunther Vrolix ◽  
Inge Depoortere ◽  
Theo Peeters ◽  
Eric Van Marck
Keyword(s):  
Liver Fibrosis ◽  
Schistosoma Mansoni ◽  
Therapeutic Effect ◽  
Neuropeptide Hormone
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