The effects of verapamil and its combinations with glutamate and glycine on cardiodynamics, coronary flow and oxidative stress in isolated rat heart

2016 ◽  
Vol 73 (1) ◽  
pp. 141-153 ◽  
Author(s):  
Isidora Stojic ◽  
Ivan Srejovic ◽  
Vladimir Zivkovic ◽  
Nevena Jeremic ◽  
Marko Djuric ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
And Oxidative Stress ◽  
Isolated Rat

The effects of nimodipine and L-NAME on coronary flow and oxidative stress parameters in isolated rat heart

2006 ◽  
Vol 93 (4) ◽  
pp. 251-261 ◽  
Author(s):  
VLj Jakovljevic ◽  
VLj Jakovljevic ◽  
PS Canovic ◽  
PS Canovic ◽  
PS Canovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Heart ◽  
Coronary Flow ◽  
Isolated Rat Heart ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters ◽  
Isolated Rat

scholarly journals Effect of oleuropein on myocardial dysfunction and oxidative stress induced by ischemic-reperfusion injury in isolated rat heart

2016 ◽  
Vol 7 (4) ◽  
pp. 224-230 ◽  
Author(s):  
Mansour Esmailidehaj ◽  
Shirin Bajoovand ◽  
Mohammad Ebrahim Rezvani ◽  
Mozhdeh Sherifidehaj ◽  
Zahra Hafezimoghadam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reperfusion Injury ◽  
Rat Heart ◽  
Myocardial Dysfunction ◽  
Isolated Rat Heart ◽  
Ischemic Reperfusion Injury ◽  
Ischemic Reperfusion ◽  
And Oxidative Stress ◽  
Isolated Rat

scholarly journals Effects of DL-Homocysteine Thiolactone on Cardiac Contractility, Coronary Flow, and Oxidative Stress Markers in the Isolated Rat Heart: The Role of Different Gasotransmitters

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Vladimir Zivkovic ◽  
Vladimir Jakovljevic ◽  
Olga Pechanova ◽  
Ivan Srejovic ◽  
Jovana Joksimovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coronary Flow ◽  
Cardiac Contractility ◽  
Isolated Rat Heart ◽  
Oxidative Stress Markers ◽  
Homocysteine Thiolactone ◽  
Stress Markers ◽  
And Oxidative Stress ◽  
Isolated Rat

Considering the adverse effects of DL-homocysteine thiolactone hydrochloride (DL-Hcy TLHC) on vascular function and the possible role of oxidative stress in these mechanisms, the aim of this study was to assess the influence of DL-Hcy TLHC alone and in combination with specific inhibitors of important gasotransmitters, such as L-NAME, DL-PAG, and PPR IX, on cardiac contractility, coronary flow, and oxidative stress markers in an isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique at a 70 cm H2O and administered 10 μM DL-Hcy TLHC alone or in combination with 30 μM L-NAME, 10 μM DL-PAG, or 10 μM PPR IX. The following parameters were measured:dp/dtmax,dp/dtmin, SLVP, DLVP, MBP, HR, and CF. Oxidative stress markers were measured spectrophotometrically in coronary effluent through TBARS, NO2,O2-, and H2O2concentrations. The administration of DL-Hcy TLHC alone decreaseddp/dtmax, SLVP, and CF but did not change any oxidative stress parameters. DL-Hcy TLHC with L-NAME decreased CF,O2-, H2O2, and TBARS. The administration of DL-Hcy TLHC with DL-PAG significantly increaseddp/dtmax but decreased DLVP, CF, and TBARS. Administration of DL-Hcy TLHC with PPR IX caused a decrease indp/dtmax, SLVP, HR, CF, and TBARS.

The effects of the modulation of NMDA receptors by homocysteine thiolactone and dizocilpine on cardiodynamics and oxidative stress in isolated rat heart

2014 ◽  
Vol 401 (1-2) ◽  
pp. 97-105 ◽  
Author(s):  
Ivan Srejovic ◽  
Vladimir Jakovljevic ◽  
Vladimir Zivkovic ◽  
Nevena Barudzic ◽  
Ana Radovanovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nmda Receptors ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Homocysteine Thiolactone ◽  
And Oxidative Stress ◽  
Isolated Rat

Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA

1999 ◽  
Vol 276 (6) ◽  
pp. H2076-H2084 ◽  
Author(s):  
Robert D. Lasley ◽  
Prakash Narayan ◽  
M. Salik Jahania ◽  
Elizabeth L. Partin ◽  
Kathleen R. Kraft ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Rat Heart ◽  
Coronary Flow ◽  
Receptor Activation ◽  
Isolated Rat Heart ◽  
Pressure Effects ◽  
Hemodynamic Effects ◽  
Receptor Agonists ◽  
Coronary Dilation ◽  
Isolated Rat

The purpose of this study was to compare the hemodynamic effects of the adenosine A3-receptor agonists N 6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-β-d-ribofuranosyl]adenine (IB-MECA) and 2-chloro- N 6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-β-d-ribofuranosyl]adenine (Cl-IB-MECA) in isolated rat and rabbit hearts and in the intact, open-chest pig. Isolated hearts perfused with Krebs-Henseleit buffer at a constant pressure (70 mmHg) were treated with 50 nM of either IB-MECA or Cl-IB-MECA. Neither IB-MECA nor Cl-IB-MECA altered ventricular function or heart rate in the isolated rat and rabbit hearts, and neither agent altered coronary flow in the rabbit. However, 2 min of IB-MECA treatment in the isolated rat heart increased coronary flow by 25%, an effect that did not exhibit tachyphylaxis. The IB-MECA-induced coronary dilation was only partially attenuated by the adenosine A3-receptor antagonist MRS-1191 (50 nM). IB-MECA-induced coronary dilation was completely blocked by the adenosine A2a-receptor antagonist 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (Sch-58261, 50 nM). Cl-IB-MECA (50 nM) did not increase coronary flow in the rat, but 100 nM did increase flow by 18%. In pentobarbital sodium-anesthetized pigs IB-MECA (5 μg/kg iv) decreased systemic blood pressure and increased pulmonary artery pressure, effects that did exhibit tachyphylaxis. These results illustrate that adenosine A3-receptor agonists produce species-dependent effects, which in the rat heart appear to be caused by adenosine A2a-receptor activation.

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